Abstract
Proteomics has helped us to understand physiological functioning as well as pathological condition. Mesial temporal lobe epilepsy (MTLE), the most common type of focal epilepsy in humans, is frequently associated with hippocampal cell loss, cognitive deficit, and resistance to antiseizure medications (ASM). A major challenge in designing new treatments to control seizures or epileptogenesis is the sequence of events involved in the development of an epileptic focus. Neuroproteomics emerges as a powerful tool for the assessment of protein biomarkers in neurodegenerative diseases, including MTLE. In this chapter, we present the main techniques used in proteomics studies to determine differential expression of proteins in brain tissue or other biological samples from patients and experimental models of epilepsy. Data obtained with proteomics are very useful to understand the pathophysiology of MTLE and, in the future, may assist in finding target proteins for new therapies.
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Fernandes, M.J.d.S., Pereira, A.S., Jaures, C.C.P.R., Prudencio, M.B., Persike, D.S. (2023). Application of Proteomics in the Study of Molecular Markers in Epilepsy. In: Rocha, L.L., Lazarowski, A., Cavalheiro, E.A. (eds) Pharmacoresistance in Epilepsy. Springer, Cham. https://doi.org/10.1007/978-3-031-36526-3_15
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