Burden of Disease

  • Chapter
  • First Online:
Obstructive Sleep Apnea

Abstract

Background: The burden of disease of obstructive sleep apnea (OSA) is highly underestimated by policy-makers. Therefore, diagnosis and treatment of OSA are often not prioritized in healthcare budget decision-making.

Objective: Analysis on the effect of OSA as a risk factor for other comorbidities on the (economic) burden of the disease, compared to OSA as a “stand-alone” medical condition.

Methods: Literature evaluation on the burden of disease of OSA.

Results: OSA is a risk factor for comorbidities such as ischemic heart disease, stroke, and diabetes mellitus which are listed in the top three World Health Organization (WHO) global causes of disability-adjusted life years (DALYs). With a broader society perspective, cost of illness studies of OSA conclude that the disease produces a substantial economic burden, with indirect costs due to morbidity as one of the main cost drivers. Instead of focusing on direct treatment costs of OSA, publications emphasizing the potential economic benefit from a payer perspective are increasing and with positive results. Cost-effectiveness analysis defining OSA as a risk factor for comorbidities concludes positively; society benefits from treating OSA.

Conclusion: The disease burden of OSA as a risk factor for comorbidities is higher than OSA as a “stand-alone” medical condition. Additionally, the treatment of OSA is economically beneficial. This evaluation serves as a call for action to prioritize the treatment and diagnosis of OSA in healthcare budget decision-making by policy-makers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
GBP 19.95
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
GBP 143.50
Price includes VAT (United Kingdom)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
GBP 179.99
Price includes VAT (United Kingdom)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Wickwire E. Value-based sleep and breathing: health economic aspects of obstructive sleep apnea. Faculty Rev. 2021;10(40) https://doi.org/10.12703/r/10-40.

  2. Blissett D, Blissett R. Synchronized hypoglossal nerve stimulation with inspire for untreated severe obstructive sleep apnoea/hypopnoea syndrome: a simulated cost-utility analysis from a National Health Service Perspective. Pharmacoecon Open. 2021;5(3):475–89.

    Article  PubMed  PubMed Central  Google Scholar 

  3. NCCID. Understanding summary measures used to estimate the burden of disease: all about HALY’s, DALYS and QALYS; 2015.

    Google Scholar 

  4. Wickwire E, Towe M. The impact of treatments for OSA on monetized health economic outcomes: a systematic review. Chest. 2019;155(5):947–61.

    Article  PubMed  Google Scholar 

  5. WHO Disease Burden 2000–2019. https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/global-health-estimates-leading-causes-of-dalys

  6. Himanshu W. What is the mortality rate for sleep apnea (OSA)? 2020. https://www.medscape.com/answers/295807-53497/what-is-the-mortality-rate-for-sleep-apnea-osa

  7. Jose M, Alvar G. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046–53.

    Article  Google Scholar 

  8. Young T, Stubbs R. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008;31(8):1071–8.

    PubMed  PubMed Central  Google Scholar 

  9. Pietzsch J, Geisler BP. Clinical and economic benefits of upper airway stimulation for obstructive sleep apnea in a European setting. Respiration. 2019;98(1):38–47.

    Article  PubMed  Google Scholar 

  10. Pevernagie D, Grote L. On the rise and fall of the apnea−hypopnea index: a historical review and critical appraisal. J Sleep Res. 2020;00:e13066. https://doi.org/10.1111/jsr.13066.

    Article  Google Scholar 

  11. AlGhanim N, Ajas N. The economic impact of obstructive sleep. Apnea. 2007;186:7–12.

    Google Scholar 

  12. Guest JF. Clinical outcomes and cost-effectiveness of continuous positive airway pressure to manage obstructive sleep apnea in patients with type 2 diabetes in the U.K. Diabetes Care. 2014;37(5):1263–71.

    Article  PubMed  Google Scholar 

  13. Frost and Sullivan. American Academy of Sleep Medicine: Hidden health crisis costing America billions: Underdiagnosing and undertreating obstructive sleep apnea draining healthcare system; 2016. https://aasm.org/resources/pdf/sleep-apnea-economic-crisis.pdf

  14. Grunstein R, Sjostrom L. Impact of self-reported sleep-breathing disturbances on psychosocialperformance in the Swedish obese subjects (SOS) study. Sleep. 1995;18:635–43.

    Article  CAS  PubMed  Google Scholar 

  15. Jennum P, Kjellberg J. Health, social and economical consequences of sleep- disordered breathing: a controlled national study. Thorax. 2011;66:560–6.

    Article  PubMed  Google Scholar 

  16. Jennum P, Kjellberg J. Social consequences of sleep disordered breathing on patients and their partners. A controlled national study. Eur Respir J. 2013;43(1):134–44.

    Article  PubMed  Google Scholar 

  17. Young T. Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep. 1997;20(9):705–6.

    Article  CAS  PubMed  Google Scholar 

  18. Bahammam A, Kryger M. Health care utilization in males with obstructive sleep apnea syndrome two years after diagnosis and treatment. Sleep. 1999;22(6):740–7.

    Article  CAS  PubMed  Google Scholar 

  19. Taraskiuka A, Reuvenib H. The economic impact of obstructive sleep apnea. Curr Opin Pulm Med. 2013;19(6):639–44.

    Article  Google Scholar 

  20. Gami A, Somers V. Association of atrial fibrillation and obstructive sleep apnea. Circulation. 2004;110:364–7.

    Article  PubMed  Google Scholar 

  21. Harris M, Grunstein R. Obstructive sleep apnea and depression. Sleep Med Rev. 2009;13:437–44.

    Article  PubMed  Google Scholar 

  22. FIRS. The global burden of sleep apnoea; 2019. doi: https://doi.org/10.1016/S2213-2600(19)30226-7.

  23. Benjafield A, Eastwood P. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7:687–98.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lyons M, Magalang U. Global burden of sleep-disordered breathing and its implications. Respirology. 2020;25(7):690–702.

    Article  PubMed  Google Scholar 

  25. Afshin A, Murray C. Health effects of overweight and obesity in 195 countries. N Engl J Med. 2017;377:1496–7.

    PubMed  Google Scholar 

  26. Romero-Corral A, Somers V. Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest. 2010;137:711–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Peppard P, Hla K. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177:1006–14.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Schwartz A, Smith PL. Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proc Am Thorac Soc. 2008;5:185–92.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kim J, Park C (2004) Prevalence of sleep-disordered breathing in middle-aged Korean men and women. Am J Respir Crit Care Med170: 1108–1113.

    Google Scholar 

  30. Linz B, Hohl M. Repeated exposure to transient obstructive sleep apnea–related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rythm. 2021;18(3):455–64.

    Article  Google Scholar 

  31. Wickwire E. Value-based sleep and breathing: health economic aspects of obstructive sleep apnea. Fac Rev. 2021;10:40.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Wickwire E, Scharf S. The impact on monetized health economic outcomes of treatments for OSAA systematic review. Chest. 2019;155(5):947–61.

    Article  PubMed  Google Scholar 

  33. Potts KJ, Sims P. Cost savings associated with an education campaign on the diagnosis and management of sleep-disordered breathing: a retrospective, claims-based US study. Popul Health Manag. 2013;16:7–1.

    Article  PubMed  Google Scholar 

  34. Brouwer W. When is it too expensive? Cost-effectiveness thresholds and health care decision-making. Eur J Health Econ. 2019;20(2):175–80.

    Article  PubMed  Google Scholar 

  35. Edney LC. Estimating the reference incremental cost-effectiveness ratio for the Australian health system. PharmacoEcon. 2018;36(2):239–52.

    Article  Google Scholar 

  36. Billings M, Kapur V. Medicare long-term CPAP coverage policy: a cost-utility analysis. J Clin Sleep Med. 2013;9(10):1023–9.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Catala R, Merino M. Cost-effectiveness of continuous positive airway pressure treatment in moderate-severe obstructive sleep apnea syndrome, Arch Bronconeumol. 2016;52(9):461–9.

    Google Scholar 

  38. Guest J, Stradling J. Cost-effectiveness of using continuous positive airway pressure in the treatment of severe obstructive sleep apnoea/hypopnoea syndrome in the UK. Thorax. 2008;63(10):860–5.

    Article  CAS  PubMed  Google Scholar 

  39. McDaid C, Weatherly H. Continuous positive airway pressure devices for the treatment of obstructive sleep apnoea-hypopnoea syndrome: a systematic review and economic analysis. Health Technol Assess. 2009;13(4).:iii–iv, xi–xiv, 1–119, 143–274.

    Google Scholar 

  40. Poullie A, Gauthier A. Cost-effectiveness of treatments for mild- to-moderate obstructive sleep apnea in France. Int J Technol Assess Health Care. 2016;32(1–2):37–45.

    Article  PubMed  Google Scholar 

  41. Weatherly HL, Mc Daid C. An economic analysis of continuous positive airway pressure for the treatment of obstructive sleep apnea-hypopnea syndrome. Int J Technol Assess Health Care. 2009;25(1):26–34.

    Article  PubMed  Google Scholar 

  42. Sleep Health Foundation & Deloitte Access Economics. Asleep on the job: costs of inadequate sleep in Australia; 2017. https://www.sleephealthfoundation.org.au/files/Asleep_on_the_job/Asleep_on_the_Job_SHF_report-WEB_small.pdf

  43. Streatfeild J, Pezullo L. Cost-effectiveness of continuous positive airway pressure therapy for obstructive sleep apnea: health care system and societal perspectives. Sleep. 2019;42:zsz181–12.

    Article  PubMed  Google Scholar 

  44. Armeni P, Gupta A. Cost-of-illness study of obstructive sleep apnea syndrome (OSAS) in Italy. SDA Bocconi School of Management; 2019.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Carrasco-Llatas, M., Wollny, M., Bos, N. (2023). Burden of Disease. In: Baptista, P.M., Lugo Saldaña, R., Amado, S. (eds) Obstructive Sleep Apnea. Springer, Cham. https://doi.org/10.1007/978-3-031-35225-6_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-35225-6_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-35224-9

  • Online ISBN: 978-3-031-35225-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation