Abstract
Parkinson’s Disease (PD) is a progressive neurological disorder affecting the Basal Ganglia (BG) region in the mid-brain producing degeneration of motor abilities. The severity assessment is generally analyzed through Unified Parkinson’s Disease Rating Scale (UPDRS) as well as the amount changes noticed in the BG size in Positron Emission Tomography (PET) images. Predicting patients’ severity state through the analysis of these symptoms over time remains a challenging task. This paper proposes a Long Short Term Memory (LSTM) model using a newly created dataset in order to predict the next severity stage. The dataset includes the UPDRS scores and the BG size for each patient. This is performed by implementing a new algorithm that focuses on PET images and computes BG size. These computed values were then merged with UPDRS scores in a CSV file. The dataset created is fed into the proposed LSTM model for predicting the next severity stage by analyzing the severity scores over time. The model’s accuracy is assessed through several experiments and reached an accuracy of 84% which outperforms the other state-of-the-art method. These results confirm that our proposal holds great promise in providing a visualization of the next severity stage for all patients which aids physicians in monitoring disease progression and planning efficient treatment.
Supported by Université de Tunis, Institut Supérieur de Gestion de Tunis (ISGT), BESTMOD Laboratory.
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References
Alharthi, A.S., Casson, A.J., Ozanyan, K.B.: Gait spatiotemporal signal analysis for Parkinson’s disease detection and severity rating. IEEE Sens. J. 21(2), 1838–1848 (2020)
Bouktif, S., Fiaz, A., Ouni, A., Serhani, M.A.: Optimal deep learning LSTM model for electric load forecasting using feature selection and genetic algorithm: Comparison with machine learning approaches. Energies 11(7), 1636 (2018)
El Maachi, I., Bilodeau, G.A., Bouachir, W.: Deep 1D-convnet for accurate Parkinson disease detection and severity prediction from gait. Expert Syst. Appl. 143, 113075 (2020)
Goetz, C.G., et al.: Movement disorder society task force report on the Hoehn and Yahr staging scale: status and recommendations the movement disorder society task force on rating scales for Parkinson’s disease. Mov. Disord. 19(9), 1020–1028 (2004)
Goetz, C.G., et al.: Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. Official J. Mov. Disord. Soc. 23(15), 2129–2170 (2008)
Goschenhofer, J., Pfister, F.M.J., Yuksel, K.A., Bischl, B., Fietzek, U., Thomas, J.: Wearable-based Parkinson’s disease severity monitoring using deep learning. In: Brefeld, U., Fromont, E., Hotho, A., Knobbe, A., Maathuis, M., Robardet, C. (eds.) ECML PKDD 2019. LNCS (LNAI), vol. 11908, pp. 400–415. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46133-1_24
Grover, S., Bhartia, S., Yadav, A., Seeja, K., et al.: Predicting severity of Parkinson’s disease using deep learning. Procedia Comput. Sci. 132, 1788–1794 (2018)
Hochreiter, S., Schmidhuber, J.: Long short-term memory. Neural Comput. 9(8), 1735–1780 (1997)
Iakovakis, D., et al.: Screening of parkinsonian subtle fine-motor impairment from touchscreen ty** via deep learning. Sci. Rep. 10(1), 1–13 (2020)
Kim, H.B., et al.: Wrist sensor-based tremor severity quantification in Parkinson’s disease using convolutional neural network. Comput. Biol. Med. 95, 140–146 (2018)
Kingma, D.P., Ba, J.: Adam: A method for stochastic optimization. In: Proceedings of International Conference Learning Representation (ICLR), pp. 1–15 (2015)
Marek, K., et al.: The Parkinson progression marker initiative (PPMI). Prog. Neurobiol. 95(4), 629–635 (2011)
Mostafa, T.A., Cheng, I.: Parkinson’s disease detection using ensemble architecture from MR images. In: 2020 IEEE 20th International Conference on Bioinformatics and Bioengineering (BIBE), pp. 987–992. IEEE (2020)
Patterson, J., Gibson, A.: Deep Learning: A Practitioner’s Approach. O’Reilly Media Inc., Sebastopol (2017)
Pavese, N., Brooks, D.J.: Imaging neurodegeneration in Parkinson’s disease. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis. 1792(7), 722–729 (2009)
Rascol, O., Goetz, C., Koller, W., Poewe, W., Sampaio, C.: Treatment interventions for Parkinson’s disease: an evidence based assessment. Lancet 359(9317), 1589–1598 (2002)
Ravì, D., et al.: Deep learning for health informatics. IEEE J. Biomed. Health Inform. 21(1), 4–21 (2016)
** based hybrid feature extraction for diagnosis of Parkinson’s disease. NeuroImage Clin. 24, 102070 (2019)
Zhao, A., Qi, L., Li, J., Dong, J., Yu, H.: A hybrid spatio-temporal model for detection and severity rating of Parkinson’s disease from gait data. Neurocomputing 315, 1–8 (2018)
Zhao, J., et al.: Do RNN and LSTM have long memory? In: International Conference on Machine Learning, pp. 11365–11375. PMLR (2020)
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Maalej, Z., Rejab, F.B., Nouira, K. (2023). Deep Learning for Parkinson’s Disease Severity Stage Prediction Using a New Dataset. In: Rojas, I., Valenzuela, O., Rojas Ruiz, F., Herrera, L.J., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2023. Lecture Notes in Computer Science(), vol 13920. Springer, Cham. https://doi.org/10.1007/978-3-031-34960-7_8
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