Abstract
B. major is an edible medicinal plant, which aqueous and hydroethanolic rhizome extracts are used in folk medicine for the relief of diarrhea and more gastrointestinal disorders, hemorrhages, inflammations, respiratory and other infections, wounds, etc. The progress on the bistort extract research enables the discovery of new bioactive compounds, evaluation of their therapeutic potential and safety for the treatment of modern socially significant diseases. Therefore, the present review aimed to analyze the therapeutic potential of B. major extracts with an emphasis on their active molecules, and the toxicological risk of bistort use. The antioxidant phenolics are among the most investigated phytochemicals in the plant, as two new flavonoids with anti-inflammatory properties have been discovered. The herb is a source of chlorogenic, gallic acids, catechins, procyanidins, and derivatives of caffeic acid, quercetin, kaempferol, luteolin and apigenin. Some triterpenoids, phenolic acids, flavan-3-ols, flavonols, tannins, and fatty acids are among the elucidated physiologically active compounds in the extracts. They are responsible for their antibacterial, antioxidant, hemostatic, immunostimulatory, anti-inflammatory, hepatoprotective, gastroprotective, and anticancer effects. Particularly, 5-glutinen-3-one and tannic acid are promising anti-rheumatic and hepatoprotective agents, respectively. However, the role of polysaccharides in the bioactivity of the aqueous extracts is not studied. It seems that by decreasing the polarity of the extragent it can increase the possible toxic effects of the extract on the basis of toxicological studies. Considering the biological and pharmacological investigations with bistort extracts, their biomedical potential deserves to be tested in malignant, infectious, chronic inflammatory, liver, gastrointestinal, cardiovascular diseases and diabetes.
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Abbreviations
- AqE(s) :
-
Aqueous extract(s)
- AqRE(s) :
-
Aqueous rhizome extract(s)
- BM :
-
Bistorta major
- BMR :
-
BM rhizomes
- BR :
-
Bistort rhizomes
- B.W. :
-
Body weight
- GAE :
-
Gallic acid equivalents
- IC50,:
-
Half-maximal inhibitory concentration
- I.P. :
-
Intraperitoneal injection
- HAE(s) :
-
Hydroalcoholic extract(s)
- HARE(s) :
-
Hydroalcoholic rhizome extract(s)
- MBC :
-
Minimal bactericidal concentration
- MIC :
-
Minimal inhibitory concentration
- P.O. :
-
per os.
References
Staneva, D., Panova, D., Rainova, L., Asenov, I.: 5.4. Bilki, izpolzuvani pri narusheno kryvosysirvane i anemia. In: Bachvarova, M. (ed.), Bilkite vyv Vseki Dom. 1st edn. Medicina i Fizkiltura, pp. 161–162. Sofia, Bulgaria (1982). (In Bulgarian)
Klimczak, U., Woźniak, M., Tomczyk, M., Granica, S.: Chemical composition of edible aerial parts of meadow bistort (Persicaria bistorta (L.) Samp.). Food Chem. 230, 281–290 (2017). https://doi.org/10.1016/j.foodchem.2017.02.128
Tilford, G.L.: Edible and Medicinal Plants of the West. 11th edn. Mountain Press Publishing Press, pp. 18–19. Missoula, Montana, USA (2009)
Somme, L., et al.: Pollen and nectar quality drive the major and minor floral choices of bumble bees. Apidologie 46(1), 92–106 (2014). https://doi.org/10.1007/s13592-014-0307-0
Cecotti, R., Carpana, E., Falchero, L., Paoletti, R., Tava, A.: Determination of the volatile fraction of Polygonum bistorta L. at different growing stages and evaluation of its antimicrobial activity against two major honeybee (Apis mellifera) pathogens. Chem. Biodivers. 9(2), 359–369 (2012). https://doi.org/10.1002/cbdv.201100326
Babu, S., Satish, S., Mohana, D.C., Raghavendra, M.P., Raveesha, K.A.: Anti-bacterial evaluation and phytochemical analysis of some Iranian medicinal plants against plant pathogenic Xanthomonas pathovars. J. Agric. Technol. 3(2), 307–316 (2007)
Mardani, H., Kazantseva, E., Onipchenko, V., Fujii, Y.: Evaluation of allelopathic activity of 178 Caucasian plant species. Int. J. Basic Appl. Sci. 5(1), 75–81 (2016). https://doi.org/10.14419/ijbas.v5i1.5631
Zhang, Z.-F., Shen, Q., Cheung, H.-Y.: Qualitative evaluation and bioactivity assessment of Polygonum bistorta. Herb. Med. Nutraceuticals 19(4), 164–167 (2012)
Nekratova, N.A., Shurupova, M.N.: Resources of medicinal plants in the Kuznetsky Alatau. Int. J. Environ. Stud. 71(5), 656–666 (2014). https://doi.org/10.1080/00207233.2014.944790
Shikov, A.N., Pozharitskaya, O.N., Makarov, V.G., Wagner, H., Verpoorte, R., Heinrich, M.: Medicinal plants of the Russian pharmacopoeia; their history and applications. J. Ethnopharmacol. 154(3), 481–536 (2014). https://doi.org/10.1016/j.jep.2014.04.007
Song, J., et al.: Authentication of the family Polygonaceae in Chinese pharmacopoeia by DNA barcoding technique. J. Ethnopharmacol. 124(3), 434–439 (2009). https://doi.org/10.1016/j.jep.2009.05.042
Staneva, D., Panova, D., Rainova, L., Asenov, I.: 5.1.9. Bilkovi chaeve za lechenie na zabolyavaniya na hranosmilatelnata sistema. In: Bachvarova, M. (ed.), Bilkite vyv Vseki Dom, 1st edn. Medicina i Fizkiltura, p. 95. Sofia, Bulgaria (1982). (In Bulgarian)
Neshev, G., Landzhev, I.: Bilkovi retsepti pri bolesti na polovite organi. In: Tanev, K. (ed.), Spravochnik za Bilkite. 1st edn. D-r Petyr Beron, p. 207. Sofia, Bulgaria (1989)
Han, R., Xue, J., Hua, E., Zhou, L.: The high-performance liquid chromatographic fingerprints study of Awei capsules. Pharmacogn. Mag. 9(33), 67–71 (2013). https://doi.org/10.4103/0973-1296.108143
Zheng, H., et al.: Chinese patent medicine Fei-Liu-** ointment as an adjunctive treatment for non-small cell lung cancer: protocol for a systematic review. BMJ Open 7(1), e015045 (2017). https://doi.org/10.1136/bmjopen-2016-015045
Lv, J., et al.: Protective effect of Yangxue Jiedu Soup against psoriasis-like lesions by regulating TLR4/NF-κB signaling pathway mediated by secretion of exosome HSP70. Biomed. Pharmacother. 147, 112604 (2022). https://doi.org/10.1016/j.biopha.2021.112604
Ding, Z., Gao, F., Lin, P.: Long-term effect of treating patients with precancerous lesions of the esophagus. Zhonghua Zhongliu Zazhi 21, 275–277 (1999)
Oyuntsetseg, N., Chimedragchaa, C., Nomin-Erdene, J., Tsend-Ayush, D.: Effect of De-Mon syrup on lipopolysaccharide-induced acute lung injury in rats. Int. J. Appl. Res. Med. Plants 106 (2018). https://doi.org/10.29011/IJARMP-106.100006
Oyuntsetseg, N., et al.: Evaluation of direct antiviral activity of the Deva-5 herb formulation and extracts of five Asian plants against influenza a virus H3N8. BMC Complement. Altern. Med. 14, 235 (2014). https://doi.org/10.1186/1472-6882-14-235
Andre-Frei, V., Bechetoille, N., Pain, S., Rousselle, P.: Cosmetic or dermatological use of a Polygonum bistorta extract. United States Patent Application Publication US 2016/0051462 A1, 25 February 2016. https://patents.google.com/patent/US20160051462A1/en
Mehar, A., Tabarak, H.I.M.: A review on Polygonum bistorta L. with reference to its pharmacology & phytochemistry. Glob. J. Res. Med. Plants Indig. Med. 2(9), 669–674 (2019)
Voronkova, M.S., Vysochina, G.I.: Bistorta Scop. genus (Polygonaceae): Chemical composition and biological activity. Chem. Sustain. Dev. 22, 207–212 (2014)
Dong, X., et al.: Pharmacological and other bioactivities of the genus Polygonum - a review. Trop. J. Pharm. Res. 13(10), 1749–1759 (2014). https://doi.org/10.4314/tjpr.v13i10.27
Narasimhulu, G., Reddy, K.K., Mohamed, J.: The genus Polygonum (Polygonaceae): an ethnopharmacological and phytochemical perspectives – review. Int. J. Pharm. Pharm. Sci. 6(2), 21–45 (2014)
Hao, D.C., Gu, X.-J., **ao, P.G.: Chapter 12. Phytochemical and Biological Research of Polygoneae Medicinal Resources. Medicinal Plants: Chemistry, Biology and Omics. 1st edn., pp. 465–529. Woodhead Publishing, Cambridge, UK (2015). http://dx.doi.org/https://doi.org/10.1016/B978-0-08-100085-4.00012-8
Shen, B.-B., et al.: Analysis of the phytochemistry and bioactivity of the genus Polygonum of Polygonaceae. Digit. Chin. Med. 1(1), 19–36 (2018). https://doi.org/10.1016/S2589-3777(19)30005-9
Seimandi, G., et al.: An update on phytochemicals and pharmacological activities of the genus Persicaria and Polygonum. Molecules 26(19), 5956 (2021). https://doi.org/10.3390/molecules26195956
Voronkova, M.S., Vysochina, G.I., Kukushkina, T.A.: Phenolic compound content in individual plants of three species of the Bistorta (L.) Scop. Genus. Proc. Univ. Appl. Chem. Biotechnol. 9(3), 529–535 (2019). (In Russian). https://doi.org/10.21285/2227-2925-2019-9-3-529-535
Pawłowska, K.A., Hałasa, R., Dudek, M.K., Majdan, M., Jankowska, K., Granica, S.: Antibacterial and anti-inflammatory activity of bistort (Bistorta officinalis) aqueous extract and its major components. Justification of the usage of the medicinal plant material as a traditional topical agent. J. Ethnopharmacol. 260, 113077 (2020). https://doi.org/10.1016/j.jep.2020.113077
Jovanović, M., et al.: Anti-virulence potential and in vivo toxicity of Persicaria maculosa and Bistorta officinalis extracts. Molecules 25(8), 1811 (2020). https://doi.org/10.3390/molecules25081811
Wang, H., Liu, B., Du, X., Zeng. J.: Identification of the chemical constituents of the ethyl acetate extraction portion of Polygonum bistorta/ **药房. China Pharm. 12, 3494–3497 (2017)
Choi, S.Y., Kwon, Y.S., Kim, C.M.: Chemical constituents from Polygonum bistorta rhizomes. Korean J. Pharmacogn. 31(4), 426–429 (2000)
Duwiejua, M., Zeitlin, I.J., Gray, A.I., Waterman, P.G.: The anti-inflammatory compounds of Polygonum bistorta: isolation and characterisation. Planta Med. 65(4), 371–374 (1999). https://doi.org/10.1055/s-2006-960791
Sun, X.-B., Zhao, P.-H., Xu, Y.-J., Sun, L.-M., Cao, M.-A., Yuan, C.-Y.: Chemical constituents from the roots of Polygonum bistorta. Chem. Nat. Compd. 43, 563–566 (2007). https://doi.org/10.1007/s10600-007-0193-z
Manoharan, K.P., Benny, T.K.H., Yang, D.: Cycloartane type triterpenoids from the rhizomes of Polygonum bistorta. Phytochemistry 66, 2304–2308 (2005). https://doi.org/10.1016/j.phytochem.2005.07.008
Intisar, A., Zhang, L., Luo, H., Zhang, R., Wu, Z., Zhang, W.: Difference in essential oil composition of rhizome of Polygonum bistorta L. from different Asian regions and evaluation of its antibacterial activity. J. Essent. Oil Bear. Plants 15(6), 964–971 (2012). https://doi.org/10.1080/0972060X.2012.10662600
Intisar, A., Zhang, L., Luo, H., Kiazolu, B.J., Zhang, R., Zhang, W.: Anticancer constituents and cytotoxic activity of methanol-water extract of Polygonum bistorta L. Afr. J. Tradit. Complement. Altern. Med. 10(1), 53–59 (2013). https://doi.org/10.4314/ajtcam.v10i1.9
Demiray, S., Pintado, M.E., Castro, P.M.L.: Evaluation of phenolic profiles and antioxidant activities of Turkish medicinal plants: Tilia argentea, Crataegi folium leaves and Polygonum bistorta roots. Int. Sch. Sci. Res. Innov. 3(6), 74–79 (2009). https://doi.org/10.5281/zenodo.1075066
Khushtar, M., Ahmad, A., Rahman, A.: Gastroprotective effect of hydro-alcoholic extract of Polygonum bistorta Linn root in indomethacin-induced gastric ulcers in Sprague Dawley rats. Indian J. Pharm. Educ. Res. 52(4), 618–625 (2018). https://doi.org/10.5530/ijper.52.4.72
Liu, Y.-H., et al.: Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Sci. Rep. 7, 41437 (2017). https://doi.org/10.1038/srep41437
Wang, S.-T., Yang, H., Gao, W., Li, H.-J., Li., P.: Trace enrichment and characterization of polyphenols in Bistort Rhizoma using weak anion-exchange solid phase extraction and high performance liquid chromatography-quadrupole time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 119, 91–98 (2016). https://doi.org/10.1016/j.jpba.2015.11.033
Liu, X.-Q., Du, L.-L., Li, W.-W., Guan, H.-F., Liu, F.: Simultaneous qualitative and quantitative analysis of commercial Bistorta rhizome and its differentiation from closely related herbs using TLC and HPLC-DAD fingerprinting. Chem. Pharm. Bull. 56(1), 75–78 (2008). https://doi.org/10.1248/cpb.56.75
Duke, J.A., Ayensu. E.S.: Medicinal Plants of China. Medicinal Plants of the World, no. 4. Reference Publications, Inc., Algonac, Michigan, USA (1985)
Moerman. D.E.: Native American Ethnobotany. 1st edn. Timber Press, Portland, Oregon, USA (1998)
Yoshitama, K., Nishino, H., Ozawa, H., Sakatani, M., Okabe, Y., Ishikura, N.: Distribution pattern of anthocyanidins and anthocyanins in Polyponaceous plant. Bot. Mag. Tokyo 100, 143–149 (1987)
Iskender, N.Y., Güleç, C.A., Yücel, M., Sinek, K., Yayli, N.: Analysis of the essential oil from the flower of Polygonum bistorta L. subsp. carneum (Koch). Asian J. Chem. 23(5), 1940–1942 (2011)
Pillai, M.K., Huat, B.T.K., Yang, D.: A New Cycloartane-type triterpenoid from Polygonum bistorta. Chem. Nat. Compd. 55(6), 1085–1089 (2019). https://doi.org/10.1007/s10600-019-02900-7
Liu, X.-Q., Hua, H.-M., Liu, J., Chen, F.-K., Wu, L.J.: A new tannin-related compound from the rhizome of Polygonum bistorta L. J. Asian Nat. Prod. Res. 8(4), 299–302 (2006). https://doi.org/10.1080/10286020500034956
Partovi, T., Zabihi, M.: Coagulant compounds from rhizomes of Polygonum bistorta (Linn.). Glob. Adv. Res. J. Eng. Technol. Innov. 1(6), 127–130 (2012)
Sharma, N., Kaushik, S.: Antimicrobial and phytochemical studies on twelve medicinal plants against multidrug resistant Staphylococcus aureus. Int. J. Adv. Res. Biotechnol. Nanobiotechnol. 1(I), 39–46 (2019)
Zou, Z., Tao, T., Li, H., Zhu, X.: mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges. Cell Biosci. 10, 31 (2020). https://doi.org/10.1186/s13578-020-00396-1
Mittal, D.K., Joshi, D.: Evaluation of DNA damage by comet and MTT-assay in liver treated with Polygonum bistorta and tannic acid. Int. J. Pharm. Bio. Sci. 3(1), 375–382 (2012)
Kumar, M.D., Deepmala, J., Sangeeta, S.: Hepatoprotective effects of Polygonum bistorta and its active principles on Albino rats intoxicated with carbon tetrachloride and paracetamol. Open Access Sci. Rep. 1(4), 226 (2012). https://doi.org/10.4172/scientificreports.226
Mittal, D.K., Jena, A.K., Joshi, D.: Mechanism of Polygonum bistorta and Zingiber roseum against toxicity. J. Drug Metab. Toxicol. 5(1), 161 (2014). https://doi.org/10.4172/2157-7609.1000161
Safavi, E., Homayouni-Tabrizi, M., Karimi, E., Mohammad, G.R.K.S.: Biosynthesis of zinc oxide nanoparticles using anjbar (root of Persicaria bistorta) extract and their cytotoxic effects on human breast cancer cell line (MCF-7). IET Nanobiotechnol. 13(7), 736–741 (2019). https://doi.org/10.1049/iet-nbt.2018.5060
Kumar, M.D., Deepmala, J., Sangeeta, S.: Antioxidant, antipyretic and choleretic activities of crude extract and active compound of Polygonum Bistorta (Linn.) in albino rats. Int. J. Pharm. Biol. Sci. 2(1), 25–31 (2012)
Zeng, Z.-Y., Wang, M., Ye, H.-Y., Zhou, L., Zhou, Q., Zeng, J.: Analgesic effect of Polygonum bistorta L. water extract. Chin. J. Clin. Rehabil. 10, 199–201 (2006)
Khan, M.A., Younas, M., Khan, I., Abbas, R.Z., Ali, M.: Comparative efficacy of some herbal and homeopathic preparations against coccidiosis in broilers. Int. J. Agric. Biol. 10(3), 358–360 (2008)
Azadi F., Karimi-Jashni, A., Zerafat, M.M.: Green synthesis and optimization of nano-magnetite using Persicaria bistorta root extract and its application for rosewater distillation wastewater treatment. Ecotoxicol. Environ. Saf. 165, 467–475 (2018). https://doi.org/10.1016/j.ecoenv.2018.09.032
Satish, S., Mohana, D.C., Raghavendra, M.P., Babu, S., Raveesha, K.A.: Antibacterial evaluation of some Iranian medicinal plants against some human pathogenic bacteria. Asian J. Microbiol. Biotechnol. Environ. Exp. Sci. 11(4), 735–738 (2009)
Liu, Y., Nielsen, M., Staerk, D., Jäger, A.K.: High-resolution bacterial growth inhibition profiling combined with HPLC–HRMS–SPE–NMR for identification of antibacterial constituents in Chinese plants used to treat snakebites. J. Ethnopharmacol. 155, 1276–1283 (2014). https://doi.org/10.1016/j.jep.2014.07.019
Munir, N., Ijaz, W., Altaf, I., Naz, S.: Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta. Asian Pac. J. Trop. Biomed. 4(Suppl 2), S639–S643 (2014). https://doi.org/10.12980/APJTB.4.201414B182
Smolarz, H.D., Skwarek, T.: The investigations into the interferon-like activity of Polygonum L. genus. Acta Poloniae Pharm. Drug Res. 56(6), 459–462 (1999). https://doi.org/10.21285/2227-2925-2019-9-3-529-535
Nikawa, M., Wu, A.-F., Sato, T., Nagase, H., Kito, H.: Effects of Chinese medicinal plant extracts on mutagenicity of trp-p-1. Nat. Med. 49(3), 329–331 (1995)
Ali, M.Z., Janbaz, K.H., Mehmood, M.H., Gilani, A.-H.: Antidiarrheal and antispasmodic activities of Polygonum bistorta rhizomes are mediated predominantly through K+ channels activation. Bangladesh J. Pharmacol. 10(3), 627–634 (2015). https://doi.org/10.3329/bjp.v10i3.23714
Zaidi, S.F., et al.: Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells. J. Ethnopharmacol. 141, 403–410 (2012). https://doi.org/10.1016/j.jep.2012.03.001
Li, K., Luan, X.: Immunoregulatory function of the ethanol extracts from Rhizoma Bistortae. Med. Plant 4(1), 75–78, 82 (2013)
Orbán-Gyapai, O., Lajter, I., Hohmann, J., Jakab, G., Vasas, A.: Xanthine oxidase-inhibitory activity of extracts prepared from Polygonaceae species. Phytother. Res. 29(3), 459–465 (2015). https://doi.org/10.1002/ptr.5275
Duwiejua, M., Zeitlin, I.J., Waterman, P.G., Gray, A.I.: Anti-inflammatory activity of Polygonum bistorta, Guaiacum officinale and Hamamelis virginiana in rats. J. Pharm. Pharmacol. 46(4), 286–290 (1994). https://doi.org/10.1111/j.2042-7158.1994.tb03795.x
Salehi, E., Sharifabad, M.M., Karimi, M., Zavareh, M.S.: The effect of hydro alcoholic extract of Bistort (Polygonum bistorta L) root on blood glucose concentration of streptozotocin induced diabetic mice. Q. Sci. J. Appl. Biol. 35(1), 156–166 (2022). Ser. 70. 22051/JAB.2021.34309.1398
Ye, H.-Y., et al.: Protective effect of Polygonum bistora L. n-butyl alcohol extract on myocardial ischemia/reperfusion injury in rats in a dosage dependent manner. LiShiZhen Med. Mater. Med. Res. 17(6), 907–909 (2006)
Li, L., Huang, Z., **ao, H., Chen, X., Zeng, J.: Effect of PBNA on the NO content and NOS activity in ischemia/reperfusion injury in the rat retina. In: Anderson, R., Hollyfield, J., LaVail, M. (eds.) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol. 664, pp. 501–507. Springer, New York, NY (2010). https://doi.org/10.1007/978-1-4419-1399-9_57
Manoharan, K.P., Yang, D., Hsu, A., Huat, B.T.: Evaluation of Polygonum bistorta for anticancer potential using selected cancer cell lines. Med. Chem. 3(2), 121–126 (2007). https://doi.org/10.2174/157340607780059495
Pîrvu, L., et al.: Polygonum bistorta L. Herba et flores. Polyphenols profile, antioxidant properties and cytotoxic effect on murine fibroblast cell line NH3T3. Farmacia 65(4), 571–576 (2017)
Pershukova, A.M., Makarova, N.V., Kryukova, L.I.: Izvestiya Akademiya Nauk Kazakhskoi S. S. R. Seriya biologicheskaya 1, 78 (1991)
Wu, Y., et al.: NMR-based metabolomic approach to understanding Zeng-Sheng-**-induced hepatotoxicity, and identifying possible toxic constituents by LC-MS profiles. J. Pharm. Biomed. Anal. 217, 114833 (2022). https://doi.org/10.1016/j.jpba.2022.114833
Pillai, M.K.: Evaluation of the extracts from rhizomes of Polygonum bistorta for the median lethal dosages in Swiss albino mice. Iran. J. Toxicol. 15(3), 135–142 (2021). https://doi.org/10.32598/ijt.15.3.716.1
Wang, S.-T., et al.: Phenol profiles and antioxidant capacities of Bistort Rhizoma (Polygonum bistorta L.) extracts. RSC Adv. 6, 27320–27328 (2016). https://doi.org/10.1039/C6RA00687F
Baldwin, A., Booth, B.W.: Biomedical applications of tannic acid. J. Biomater. Appl. 36(8), 1503–1523 (2022). https://doi.org/10.1177/08853282211058099
Lv, L., Cheng, Y., Zheng, T., Li, X., Zhai, R.: Purification, antioxidant activity and antiglycation of polysaccharides from Polygonum multiflorum Thunb. Carbohyd. Polym. 99, 765–773 (2014). https://doi.org/10.1016/j.carbpol.2013.09.007
Lai, X.-X., Li, Y.-P.: Antitumor effect and mechanism of action of polysaccharides extracted from Polygonum perfoliatum L whole plant in human lung carcinoma A549 cell line. Trop. J. Pharm. Res. 15(6), 1243–1249 (2016). https://doi.org/10.4314/tjpr.v15i6.17
Georgiev, Y.N., et al.: Structural characterization of polysaccharides from Geranium sanguineum L. and their immunomodulatory effects in response to inflammatory agents. J. Nopharmacol. 294, 115390 (2022). https://doi.org/10.1016/j.jep.2022.115390
Georgiev, Y.N., et al.: The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer’s patch cells. Carbohydr. Polym. 174, 948–959 (2017). https://doi.org/10.1016/j.carbpol.2017.07.011
Georgiev, Y.N., et al.: Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I. Carbohyd. Polym. 175, 178–191 (2017). https://doi.org/10.1016/j.carbpol.2017.07.073
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Georgiev, Y.N., Ognyanov, M.H., Denev, P.N. (2023). Phytochemical Composition and Therapeutic Potential of Bistorta major Gray: A Review. In: Sotirov, S., Pencheva, T., Kacprzyk, J., Atanassov, K.T., Sotirova, E., Ribagin, S. (eds) Recent Contributions to Bioinformatics and Biomedical Sciences and Engineering. BioInfoMed 2022. Lecture Notes in Networks and Systems, vol 658. Springer, Cham. https://doi.org/10.1007/978-3-031-31069-0_17
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