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Endocrinology and Metabolism

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Abstract

Graves’ disease (GD) is an autoimmune disorder characterized by hyperthyroidism, thyroid goiter, and ophthalmopathy. The disease arises due to the production of autoantibodies that auto-stimulates the thyrotropin receptors in the thyroid gland to secrete thyroid hormones.

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Further Reading

Graves’ Disease (Hyperthyroidism)

  • Arslan H, et al. Power Doppler sonography in the diagnosis of Graves’ disease. Eur J Ultrasound. 2000;11:117–22.

    Article  CAS  PubMed  Google Scholar 

  • Babcock DS. Thyroid disease in pediatric patient: emphasizing imaging with sonography. Pediatr Radiol. 2006;36:299–308.

    Article  PubMed  Google Scholar 

  • Birchall D, et al. Graves ophthalmopathy: intracranial fat prolapse on CT images as an indicator of optic nerve compression. Radiology. 1996;200:123–7.

    Article  CAS  PubMed  Google Scholar 

  • Charkes ND, et al. MR imaging in thyroid disorders: correlation of signal intensity with Graves disease activity. Radiology. 1987;164:491–4.

    Article  CAS  PubMed  Google Scholar 

  • Greer MA, et al. Hyperthyroidism. Dis Mon. 1967;13:1–45.

    Article  Google Scholar 

  • Nugent RA, et al. Graves orbitopathy: correlation of CT and clinical findings. Radiology. 1990;177:657–82.

    Article  Google Scholar 

  • Ralls PW, et al. Color-flow Doppler sonography in Graves disease: “thyroid inferno”. AJR Am J Roentgenol. 1988;150:781–4.

    Article  CAS  PubMed  Google Scholar 

  • Rawson RW. Hyperthyroidism. Dis Mon. 1955;1:3–43.

    Article  Google Scholar 

  • Reed LP. Hyperthyroidism. Dis Mon. 1976;22:1–30.

    Article  Google Scholar 

Hyperparathyroidism

  • Ahuja AT, et al. Imaging of primary hyperparathyroidism—what beginners should know. Clin Radiol. 2004;59:967–76.

    Article  CAS  PubMed  Google Scholar 

  • Bertolini F, et al. Multiple ossifying fibromas of the jaw: a case report. J Oral Maxillofac Surg. 2002;60:225–9.

    Article  PubMed  Google Scholar 

  • Eggert P, et al. Nephrocalcinosis in three siblings with idiopathic hypercalciuria. Pediatr Nephrol. 1998;12:144–6.

    Article  CAS  PubMed  Google Scholar 

  • Falchetti A, et al. Multiple endocrine neoplasia type I variants and phenotypes: more than nosological issue. J Clin Endocrinol Metab. 2009;94:1518–20.

    Article  CAS  PubMed  Google Scholar 

  • Ghanaat F, et al. Hungry bone syndrome: a case report and review of the literature. Nutr Res. 2004;24:633–8.

    Article  CAS  Google Scholar 

  • Hsieh M-C, et al. Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. Arch Orthop Trauma Surg. 2004;124:489–501.

    Article  Google Scholar 

  • Kabala JE. Computed tomography and magnetic resonance imaging in diseases of the thyroid and the parathyroid. Eur J Radiol. 2008;66:480–92.

    Article  CAS  PubMed  Google Scholar 

  • Krudy AG, et al. The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling. Radiology. 1981;140:739–44.

    Article  CAS  PubMed  Google Scholar 

  • McDonald DK, et al. Primary hyperparathyroidism due to parathyroid adenoma. Radiographics. 2005;25:829–34.

    Article  PubMed  Google Scholar 

  • Reuter K, et al. Unsuspected medullary nephrocalcinosis from furosemide administration: sonographic evaluation. J Clin Ultrasound. 1985;13:357–9.

    Article  CAS  PubMed  Google Scholar 

  • Rypins EL. Osteitis fibrosa cystica at unusual age. J Bone Joint Surg Am. 1933;15:509–12.

    Google Scholar 

  • Schmidt BP, et al. Hyperparathyroidism-jaw tumor syndrome: a case report. J Oral Maxillofac Surg. 2009;67:423–7.

    Article  PubMed  Google Scholar 

  • Smith D, et al. Hungry bones without hypocalcemia following parathyroidectomy. J Bone Miner Metab. 2005;23:514–5.

    Article  PubMed  Google Scholar 

  • Takeshita T, et al. Brown tumor with fluid-fluid levels in a patient with primary hyperparathyroidism: radiological findings. Radiat Med. 2006;24:631–4.

    Article  PubMed  Google Scholar 

  • Wang Q, et al. Power Doppler imaging findings in multilocular giant parathyroid adenoma which caused hypercalcaemic crisis. J Laryngol Otol. 1998;112:769–99.

    Article  Google Scholar 

Growth Hormone Diseases

  • Boikos SA, et al. Pituitary pathology in patients with carney complex: growth-hormone producing hyperplasia or tumors and their association with other abnormalities. Pituitary. 2006;9:203–9.

    Article  CAS  PubMed  Google Scholar 

  • Cazabat L, et al. PRKAR1A mutations in primary pigmented nodular adrenocortical disease. Pituitary. 2006;9:211–9.

    Article  CAS  PubMed  Google Scholar 

  • Chakraborty PP, et al. Laron’s syndrome in two siblings. Indian J Pediatr. 2007;74:870–1.

    Article  PubMed  Google Scholar 

  • Daughaday WH, et al. The pituitary in disorders of growth. Dis Mon. 1962;8:1–47.

    Article  Google Scholar 

  • Doppman JL, et al. Cushing syndrome due to primary pigmented nodular adrenocortical disease: findings at CT and MR imaging. Radiology. 1989;172:415–20.

    Article  CAS  PubMed  Google Scholar 

  • Elster AD. Imaging of the sella: anatomy and pathology. Semin Ultrasound CT MR. 1993;14:182–94.

    Article  CAS  PubMed  Google Scholar 

  • Fisher MS. An unusual bone change in acromegaly. Skeletal Radiol. 1978;3:177–8.

    Article  Google Scholar 

  • Frohman LA. Diseases of hypothalamic releasing factors. Dis Mon. 1976;22:1–37.

    Article  CAS  PubMed  Google Scholar 

  • Haupt HA. Anabolic steroids and growth hormones. Am J Sports Med. 1993;21:468.

    Article  CAS  PubMed  Google Scholar 

  • Jacobs P. Van Buchem disease. Postgrad Med J. 1977;53:497–506.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaplan SA. Human growth hormone. Dis Mon. 1968;14:1–33.

    Article  Google Scholar 

  • Kornerich L, et al. Laron syndrome abnormalities: spinal stenosis, Os odontoideum, degenerative changes of the atlanto-odontoid joint, and small oropharynx. AJNR Am J Neuroradiol. 2002;23:625–31.

    Google Scholar 

  • Laron Z. Growth hormone insensitivity (Laron syndrome). Rev Endocr Metab Disord. 2002;3:347–55.

    Article  CAS  PubMed  Google Scholar 

  • Laron Z. Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958–2003. J Clin Endocrinol Metab. 2004;89:1031–44.

    Article  CAS  PubMed  Google Scholar 

  • Mateus C, et al. Heterogeneity of skin manifestations in patients with Carney syndrome. J Am Acad Dermatol. 2008;59:801–10.

    Article  PubMed  Google Scholar 

  • Ron E, et al. Acromegaly and gastrointestinal cancer. Cancer. 1991;68:1673–7.

    Article  CAS  PubMed  Google Scholar 

  • Tani Y, et al. Locking of the metacarpophalangeal joints in a patient with acromegaly. Skeletal Radiol. 1999;28:655–7.

    Article  CAS  PubMed  Google Scholar 

  • Vandersteen A, et al. Cutaneous signs are important in the diagnosis of rare neoplasia syndrome Carney complex. Eur J Pediatr. 2009;168:1401–4.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wyszynski DF. Dysmorphology in the Bible and the Talmud. Teratology. 2001;64:221–5.

    Article  CAS  PubMed  Google Scholar 

Osteoporosis

  • Akpinar E, et al. The intravertebral vacuum phenomenon. Eur J Radiol Extra. 2008;66:e55–7.

    Article  Google Scholar 

  • Aloia JF, et al. Risk for osteoporosis in black women. Calcif Tissue Int. 1996;59:415–23.

    Article  CAS  PubMed  Google Scholar 

  • Cahir JG, et al. Regional migratory osteoporosis. Eur J Radiol. 2008;67:2–10.

    Article  PubMed  Google Scholar 

  • Freedman BA, et al. Kummel disease: a not-so-rare complication of osteoporotic vertebral compression fracture. J Am Board Fam Med. 2009;22:75–8.

    Article  PubMed  Google Scholar 

  • Goldring SR, et al. Metabolic bone disease: osteoporosis and osteomalacia. Dis Mon. 1981;27:1–103.

    Article  CAS  PubMed  Google Scholar 

  • Hauschild O, et al. Evaluation of Singh index for assessment of osteoporosis using digital radiography. Eur J Radiol. 2009;71:152–8.

    Article  CAS  PubMed  Google Scholar 

  • Karantanas AH. Acute bone marrow edema of the hip: role of MR imaging. Eur Radiol. 2007;17:2225–36.

    Article  PubMed  Google Scholar 

  • Kumpan W, et al. The intravertebral vacuum phenomenon. Skeletal Radiol. 1986;15:444–7.

    Article  CAS  PubMed  Google Scholar 

  • Libicher M, et al. The intravertebral vacuum phenomenon as a specific sign of osteonecrosis in vertebral compression fractures: results from a radiological and histological study. Eur Radiol. 2007;17:2248–52.

    Article  PubMed  Google Scholar 

  • Lorenc RS. Idiopathic juvenile osteoporosis. Calcif Tissue Int. 2002;70:395–7.

    Article  CAS  PubMed  Google Scholar 

  • Lutwak L, et al. Osteoporosis. Dis Mon. 1963;9:1–39.

    Article  Google Scholar 

  • Sarli M, et al. The vacuum cleft sign: an uncommon radiological sign. Osteoporos Int. 2005;16:1210–4.

    Article  CAS  PubMed  Google Scholar 

  • Vande Berg BC, et al. Bone marrow edema of the femoral head and transient osteoporosis of the hip. Eur J Radiol. 2008;67:68–77.

    Article  PubMed  Google Scholar 

  • Williamson MR, et al. Osteoporosis: diagnosis by plain chest film versus dual photon bone densitometry. Skeletal Radiol. 1990;19:27–30.

    Article  CAS  PubMed  Google Scholar 

Rickets and Osteomalacia

  • Brickley M, et al. Evaluation and rickets interpretation of residual rickets deformities in adults. Int J Osteoarchiol. 2008;20(1):54–66. https://doi.org/10.1002/oa.1007.

    Article  Google Scholar 

  • Cheong HI, et al. Phenotype and genotype of Dent’s disease in three Korean boys. Pediatr Nephrol. 2005;20:455–9.

    Article  PubMed  Google Scholar 

  • Currarino G. Sagittal synostosis in X-linked hypophosphatemic rickets and related diseases. Pediatr Radiol. 2007;37:805–12.

    Article  PubMed  Google Scholar 

  • DeJong AR, et al. Pseudotumor cerebri and nutritional rickets. Eur J Pediatr. 1985;143:219–20.

    Article  CAS  PubMed  Google Scholar 

  • Mays S, et al. Skeletal manifestations of rickets in infants and young children in a historic population from England. Am J Phys Anthropol. 2006;129:362–74.

    Article  CAS  PubMed  Google Scholar 

  • McBride A, et al. Vitamin D-resistance rickets (X-linked hypophosphatemic rickets). Curr Orthop. 2007;21:369–99.

    Article  Google Scholar 

  • Ramavat LG. Vitamin D, deficiency rickets at birth in Kuwait. Indian J Pediatr. 1999;66:37–43.

    Article  CAS  PubMed  Google Scholar 

  • Tosetto E, et al. Dent’s disease and prevalence of renal stones in dialysis patients in northeastern Italy. J Hum Genet. 2006;51:25–30.

    Article  PubMed  Google Scholar 

Scurvy

Fluorosis

Lead Poisoning (Plumbism)

Adrenal Gland Abnormalities

  • Assadi FK, et al. Liddle syndrome in a newborn infant. Pediatr Nephrol. 2002;17:609–11.

    Article  PubMed  Google Scholar 

  • Assie G, et al. The Nelson’s syndrome…revisited. Pituitary. 2004;7:209–15.

    PubMed  Google Scholar 

  • Dogra V, et al. Sonographic appearance of testicular adrenal rest tissue in congenital adrenal hyperplasia. J Ultrasound Med. 2004;23:979–81.

    Article  PubMed  Google Scholar 

  • Elsayes KM, et al. Adrenal masses: MR imaging features with pathologic correlation. Radiographics. 2004;24:S73–6.

    Article  PubMed  Google Scholar 

  • Garel L, et al. Nephrocalcinosis in Bartter’s syndrome. Pediatr Nephrol. 1988;2:315–7.

    Article  CAS  PubMed  Google Scholar 

  • Juan YH, et al. Adrenal nodular hyperplasia with so called testicular tumor of adrenogenital syndrome (adrenal rests of both testes): a case report and review of the literature. Chin J Radiol. 2008;33:41–6.

    Google Scholar 

  • Kannan CR. Diseases of the adrenal cortex. Dis Mon. 1988;34:601.

    Article  CAS  PubMed  Google Scholar 

  • Kasar PA, et al. Allgrove syndrome. Indian J Pediatr. 2007;74:959–61.

    Article  CAS  PubMed  Google Scholar 

  • Lockhart ME, et al. Imaging of adrenal masses. Eur J Radiol. 2002;41:95–112.

    Article  PubMed  Google Scholar 

  • Low G, et al. Characteristic imaging findings in Wolman’s disease. Clin Radiol Extra. 2004;59:106–8.

    Article  Google Scholar 

  • Luetscher AJ. Aldosteronism. Dis Mon. 1964;10(5):1–46.

    Article  Google Scholar 

  • Ma ES, et al. Tuberculous Addison’s disease: morphological and quantitative evaluation with multidetector-row CT. Eur J Radiol. 2007;62:352–8.

    Article  PubMed  Google Scholar 

  • Madrigal G, et al. Bartter syndrome in Costa Rica: a description of 20 cases. Pediatr Nephrol. 1997;11:296–301.

    Article  CAS  PubMed  Google Scholar 

  • Martinez-Aguayo A, et al. Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2007;92:4583–9.

    Article  CAS  PubMed  Google Scholar 

  • Mayo-Smith WW, et al. From the RSNA refresher courses, state-of-the-art adrenal imaging. Radiographics. 2001;21:995–1012.

    Article  CAS  PubMed  Google Scholar 

  • Otal P, et al. Imaging features of uncommon adrenal masses with histopathologic correlation. Radiographics. 1999;19:569–81.

    Article  CAS  PubMed  Google Scholar 

  • Puura A, et al. Gordon syndrome and succinylcholine. J Inherit Metab Dis. 2005;28:1157–8.

    Article  CAS  PubMed  Google Scholar 

  • Renken NS, et al. Magnetic resonance imaging of the adrenal glands. Semin Ultrasound CT MR. 2005;26:162–71.

    Article  PubMed  Google Scholar 

  • Rha SS, et al. The renal sinus: pathologic spectrum and multimodality imaging approach. Radiographics. 2004;24:S117–31.

    Article  PubMed  Google Scholar 

  • Shoaib SA, et al. Primary hyperaldosteronism (Conn syndrome): MR imaging findings. Radiology. 2000;214:527–31.

    Article  Google Scholar 

  • Stikkelbroeck NMML, et al. Testicular adrenal rest tumors. Eur Radiol. 2003;13:1597–603.

    Article  PubMed  Google Scholar 

  • Waragi M, et al. MRI of adrenoleukodystrophy involving predominantly the cerebellum and brain stem. Neuroradiology. 1996;38:788–91.

    Article  Google Scholar 

Sex Hormone Abnormalities

  • Angle B, et al. XY gonadal dysgenesis associated with a multiple pterygium syndrome phenotype. Am J Med Genet. 1997;68:7–11.

    Article  CAS  PubMed  Google Scholar 

  • Aso C, et al. Gray-scale and color Doppler sonography of scrotal disorders in children: an update. Radiographics. 2005;25:1197–214.

    Article  PubMed  Google Scholar 

  • Browne LP, et al. Van Wyk and Grumbach syndrome revisited: imaging and clinical findings in pre- and postpubertal girls. Pediatr Radiol. 2008;38:538–42.

    Article  PubMed  Google Scholar 

  • Chavhan GB, et al. Imaging of ambiguous genitalia: classification and diagnostic approach. Radiographics. 2008;28:1891–904.

    Article  PubMed  Google Scholar 

  • Chen H-Y, et al. Pure XY gonadal dysgenesis and agenesis in monozygotic twins. Fertil Steril. 2006;85:1059.e9–1059.e11.

    Article  PubMed  Google Scholar 

  • Cho HY, et al. Hydrothorax in a patient with Denys-Drash syndrome associated with diaphragmatic defect. Pediatr Nephrol. 2006;21:1909–12.

    Article  PubMed  Google Scholar 

  • Choi HK, et al. MR imaging of intersexuality. Radiographics. 1998;18:83–96.

    Article  CAS  PubMed  Google Scholar 

  • Christensen JD, et al. The undescended testis. Semin Ultrasound CT MR. 2007;28:307–16.

    Article  PubMed  Google Scholar 

  • Elon GM. Hermaphroditism demonstrated by computed tomography. AJR Am J Roentgenol. 1983;141:99–100.

    Article  Google Scholar 

  • Erdem CZ, et al. Polycystic ovary syndrome: dynamic contrast-enhanced ovary MR imaging. Eur J Radiol. 2004;51:48–53.

    Article  PubMed  Google Scholar 

  • Franceschi R, et al. Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty. Fertil Steril. 2009;93:1185. https://doi.org/10.1016/j.fertnstert.2008.11.016.

    Article  PubMed  Google Scholar 

  • Hedlund GL, et al. Disorders of puberty: a practical imaging approach. Semin Ultrasound CT MR. 1994;15:49–77.

    Article  CAS  PubMed  Google Scholar 

  • Hernanz-Schulman M, et al. Sonographic findings in infants with congenital adrenal hyperplasia. Pediatr Radiol. 2002;32:130–7.

    Article  PubMed  Google Scholar 

  • Hyun G, et al. A practical approach to intersex in the newborn period. Urol Clin North Am. 2004;31:435–43.

    Article  PubMed  Google Scholar 

  • Jagadhish LCTK. Van Wyk and Grumbach syndrome (a syndrome of incomplete isosexual precocity and juvenile hypothyroidism). Armed Forces Med J India. 2002;58:343–5.

    Article  CAS  Google Scholar 

  • Johnsen DE, et al. MR imaging of the sellar and juxtasellar regions. Radiographics. 1991;11:727–58.

    Article  CAS  PubMed  Google Scholar 

  • Jung SE, et al. CT and MRI findings of sex-cord stromal tumor of the ovary. AJR Am J Roentgenol. 2005;185:207–15.

    Article  PubMed  Google Scholar 

  • Karabulut N, et al. Stromal tumor of the sex cord in a woman with testicular feminization syndrome: imaging features. AJR Am J Roentgenol. 2002;178:1496–8.

    Article  PubMed  Google Scholar 

  • Kim JB, et al. A case of PAGOD syndrome with hypoplastic left heart syndrome. Int J Cardiol. 2007;114:270–1.

    Article  PubMed  Google Scholar 

  • Kodama M, et al. Aarskog syndrome with isolated growth hormone deficiency. Eur J Pediatr. 1981;135:273–6.

    Article  CAS  PubMed  Google Scholar 

  • Narlawar RS, et al. Persistent mullerian duct syndrome with teratoma in an ectopic testis: imaging features. Eur Radiol. 2001;11:955–8.

    Article  CAS  PubMed  Google Scholar 

  • Sharafuddin MJA, et al. MR imaging diagnosis of central precocious puberty: importance of changes in the shape and size of the pituitary gland. AJR Am J Roentgenol. 1994;162:1167–73.

    Article  CAS  PubMed  Google Scholar 

  • Wang Y-C, et al. Maternal and female fetal virilization caused by pregnancy luteoma. Fertil Steril. 2005;84:509.e15–7.

    Article  Google Scholar 

  • Woodward PJ, et al. Tumors and tumorlike lesions of the testes: radiologic-pathologic correlation. Radiographics. 2002;22:189–216.

    Article  PubMed  Google Scholar 

  • Wu H-C, et al. Persistent Müllerian duct syndrome with seminoma: CT findings. AJR Am J Roentgenol. 2000;174:102–4.

    Article  CAS  PubMed  Google Scholar 

  • Yagubyan M, et al. LEOPARD syndrome: a new polyaneurysm association and an update on the molecular genetics of the disease. J Vasc Surg. 2004;39:897–900.

    Article  PubMed  Google Scholar 

  • Yanai Y, et al. Androgen insensitivity syndrome with serous gonadal cyst. Fertil Steril. 2008;90:2018.e9–2018.e11.

    Article  PubMed  Google Scholar 

Sheehan Syndrome (Postpartum Hypopituitarism)

Hypothyroidism

  • Abraham GE. The history of iodine in medicine part I: from discovery to essentiality. The Original Internist. 2006a;13:29–36.

    Google Scholar 

  • Abraham GE. The history of iodine in medicine part II: the search for and the discovery of thyroid hormones. The Original Internist. 2006b;13:67–70.

    Google Scholar 

  • Abraham GE. The history of iodine in medicine part III: thyroid fixation and medical iodophobia. The Original Internist. 2006c;13:71–8.

    Google Scholar 

  • Ingbar SH, et al. Hypothyroidism. Dis Mon. 1958;4(9):1–50.

    Article  Google Scholar 

  • Morocco M, et al. Subclinical hypothyroidism in women: who to treat. Dis Mon. 2002;48(10):659–70.

    Article  PubMed  Google Scholar 

  • Pandey V, et al. Correlation between computed tomography density and functional status of the thyroid gland. J Comput Assist Tomogr. 2016;40:316–9.

    Article  PubMed  Google Scholar 

Gynecomastia

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Authors and Affiliations

  1. Department of Clinical Radiology, Amiri Hospital – Kuwait City, Kuwait City, Kuwait

    Jarrah Ali Al-Tubaikh

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  1. Jarrah Ali Al-Tubaikh
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Al-Tubaikh, J.A. (2023). Endocrinology and Metabolism. In: Internal Medicine. Springer, Cham. https://doi.org/10.1007/978-3-031-28575-2_3

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