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Bone Cells Metabolic Changes Induced by Ageing

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Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science

Part of the book series: Subcellular Biochemistry ((SCBI,volume 103))

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Abstract

Bone is a living organ that exhibits active metabolic processes, presenting constant bone formation and resorption. The bone cells that maintain local homeostasis are osteoblasts, osteoclasts, osteocytes and bone marrow stem cells, their progenitor cells. Osteoblasts are the main cells that govern bone formation, osteoclasts are involved in bone resorption, and osteocytes, the most abundant bone cells, also participate in bone remodeling. All these cells have active metabolic activities, are interconnected and influence each other, having both autocrine and paracrine effects. Ageing is associated with multiple and complex bone metabolic changes, some of which are currently incompletely elucidated. Ageing causes important functional changes in bone metabolism, influencing all resident cells, including the mineralization process of the extracellular matrix. With advancing age, a decrease in bone mass, the appearance of specific changes in the local microarchitecture, a reduction in mineralized components and in load-bearing capacity, as well as the appearance of an abnormal response to different humoral molecules have been observed. The present review points out the most important data regarding the formation, activation, functioning, and interconnection of these bone cells, as well as data on the metabolic changes that occur due to ageing.

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Authors and Affiliations

  1. Department of Rheumatology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

    Anca Cardoneanu & Elena Rezus

  2. Clinical Rehabilitation Hospital, 1st Rheumatology Clinic, Iasi, Romania

    Anca Cardoneanu & Elena Rezus

  3. Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

    Ciprian Rezus

  4. IIIrd Medical Clinic, “Saint Spiridon” Clinic Emergency County Hospital, Iasi, Romania

    Ciprian Rezus

  5. Advanced Research and Development Center for Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

    Bogdan Ionel Tamba

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  1. Anca Cardoneanu
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  2. Ciprian Rezus
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  4. Elena Rezus
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Correspondence to Bogdan Ionel Tamba .

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Editors and Affiliations

  1. Institute for Molecular Physiology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK

    Viktor I. Korolchuk

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Cardoneanu, A., Rezus, C., Tamba, B.I., Rezus, E. (2023). Bone Cells Metabolic Changes Induced by Ageing. In: Harris, J.R., Korolchuk, V.I. (eds) Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Subcellular Biochemistry, vol 103. Springer, Cham. https://doi.org/10.1007/978-3-031-26576-1_2

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