Disorders of Calcium: Hypercalcemia

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Fluid, Electrolyte and Acid-Base Disorders
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Abstract

This chapter provides causes, evaluation, clinical manifestations, biochemical abnormalities, and treatment of acute and chronic hypercalcemia explicitly. Discussion on topics such as primary hyperparathyroidism, milk (calcium) alkali syndrome, PTH-related peptide, malignancy and hypercalcemia, granulomatous diseases, hypercalcemia in critically ill patients, and checkpoint inhibitors and hypercalcemia is presented.

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References

  1. Bilezikian JP, Brandi ML, Eastell R, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. J Clin Endocrinol Metab. 2014;99:3561–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wilhelm SM, Wang TS, Ruan DT, et al. The American Association of Endocrine Surgeons Guidelines for definitive management of primary hyperparathyroidism. JAMA Surg. 2016;151:959–68.

    Article  PubMed  Google Scholar 

Suggested Reading

  1. Ashrafi F, Iraj B, Nematollahi P, et al. Pseudohypercalcemia in multiple myeloma: a case report. Int J Hematol Oncol Stem Cell Res. 2017;11:246–9.

    PubMed  PubMed Central  Google Scholar 

  2. Dumitru C, Wysolmerski J. Disorders of calcium metabolism. In: Alpern RJ, Moe OW, Caplan M, editors. Seldin and Giebisch’s The Kidney. Physiology and pathophysiology. 5th ed. San Diego: Academic Press (Elsevier); 2013. p. 2273–309.

    Google Scholar 

  3. Durant E, Singh A. ST elevation due to hypercalcemia. Am J Emerg Med. 2017;35(7):1033.e3–6.

    Article  PubMed  Google Scholar 

  4. Goldner W. Cancer-related hypercalcemia. J Oncol Pract. 2016;12(5):426–32.

    Article  PubMed  Google Scholar 

  5. Hoorn EJ, Zietse R. Disorders of calcium and magnesium balance: a physiologybased aproach. Pediatr Nephrol. 2013;28:1195–206. https://doi.org/10.1007/s00467-012-2350-2.

    Article  PubMed  Google Scholar 

  6. Maier J, Levine S. Hypercalcemia in the intensive care unit: a review of pathophysiology, diagnosis, and modern therapy. J Intensive Care Med. 2015;30(5):235–52.

    Article  PubMed  Google Scholar 

  7. Malangone S, Campen C. Hypercalcemia of malignancy. J Adv Pract Oncol. 2015;6(6):586–92.

    PubMed  PubMed Central  Google Scholar 

  8. Naffs MAB. Parathyroid hormone related peptide (PTHrP): a mini-review. Endocrinol Metab Int J. 2017;5:321–8.

    Google Scholar 

  9. Rosner MH, Dalkin AC. Onco-nephrology: the pathophysiology and treatment of malignancy-associated hypercalcemia. Clin J Am Soc Nephrol. 2012;7:1722–9.

    Article  CAS  PubMed  Google Scholar 

  10. Sharma OP. Hypercalcemia in granulomatous disorders: a clinical review. Curr Opin Pulm Med. 2000;6:442–7.

    Article  CAS  PubMed  Google Scholar 

  11. Smogorzewski MJ, Stubbs JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Skorecki K, et al., editors. Brenner & Rector’s the kidney. 10th ed. Philadelphia: Elsevier; 2016. p. 601–35.

    Google Scholar 

  12. Stewart AF. Hypercalcemia associated with cancer. N Engl J Med. 2005;352:373–8.

    Article  CAS  PubMed  Google Scholar 

  13. Turner J. Hypercalcaemia—presentation and management. Clin Med. 2017;17(3):270–3.

    Article  Google Scholar 

  14. Uppal NN, Workeneh BT, Rondon-Berrios H, et al. Electrolyte and acid-base disorders associated with cancer immunotherapy. Clin J Am Soc Nephrol. 2022;17:922–33.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Alluru S. Reddi .

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Reddi, A.S. (2023). Disorders of Calcium: Hypercalcemia. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-25810-7_19

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  • DOI: https://doi.org/10.1007/978-3-031-25810-7_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-25809-1

  • Online ISBN: 978-3-031-25810-7

  • eBook Packages: MedicineMedicine (R0)

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