Abstract
Heterogeneity of left ventricular (LV) myocardium infarction scar plays an important role as anatomical substrate in ventricular arrhythmia (VA) mechanism. LV myocardium thinning, as observed on cardiac computed tomography (CT), has been shown to correlate with LV myocardial scar and with abnormal electrical activity. In this project, we propose an automatic pipeline for VA prediction, based on CT images, using a Graph Convolutional Network (GCN). The pipeline includes the segmentation of LV masks from the input CT image, the short-axis orientation reformatting, LV myocardium thickness computation and mid-wall surface mesh generation. An average LV mesh was computed and fitted to every patient in order to use the same number of vertices with point-to-point correspondence. The GCN model was trained using the thickness value as the node feature and the atlas edges as the adjacency matrix. This allows the model to process the data on the 3D patient anatomy and bypass the “grid" structure limitation of the traditional convolutional neural network. The model was trained and evaluated on a dataset of 600 patients (27\(\%\) VA), using 451 (3/4) and 149 (1/4) patients as training and testing data, respectively. The evaluation results showed that the graph model (\(81\%\) accuracy) outperformed the clinical baseline (\(67\%\)), the left ventricular ejection fraction, and the scar size (\(73\%\)). We further studied the interpretability of the trained model using LIME and integrated gradients and found promising results on the personalised discovering of the specific regions within the infarct area related to the arrhythmogenesis.
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References
Bône, A., Louis, M., Martin, B., Durrleman, S.: Deformetrica 4: An Open-Source Software for Statistical Shape Analysis. In: Reuter, M., Wachinger, C., Lombaert, H., Paniagua, B., Lüthi, M., Egger, B. (eds.) ShapeMI 2018. LNCS, vol. 11167, pp. 3–13. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-04747-4_1
Garreau, D., Mardaoui, D.: What does LIME really see in images? In: Meila, M., Zhang, T. (eds.) Proceedings of the 38th International Conference on Machine Learning. Proceedings of Machine Learning Research, PMLR (2021)
Kipf, T.N., Welling, M.: Semi-supervised classification with graph convolutional networks. In: 5th International Conference on Learning Representations, ICLR 2017 - Conference Track Proceedings (2017)
Ly, B., Finsterbach, S., Nuñez-Garcia, M., Cochet, H., Sermesant, M.: Scar-related ventricular arrhythmia prediction from imaging using explainable deep learning. In: Ennis, D.B., Perotti, L.E., Wang, V.Y. (eds.) FIMH 2021. LNCS, vol. 12738, pp. 461–470. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-78710-3_44
Mahida, S., et al.: Cardiac Imaging in Patients with Ventricular Tachycardia. Circulation (2017)
Nielsen, J.C., et al.: European heart rhythm association (ehra)/heart rhythm society (hrs)/asia pacific heart rhythm society (aphrs)/latin american heart rhythm society (lahrs) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Europace (2020)
Nuñez-Garcia, M., Cedilnik, N., Jia, S., Sermesant, M., Cochet, H.: automatic multiplanar CT Reformatting from trans-axial into left ventricle short-axis view. In: STACOM 2020–11th International Workshop on Statistical Atlases and Computational Models of the Heart, Lima, Peru (Oct 2020)
Ribeiro, M.T., Singh, S., Guestrin, C.: “Why should i trust you?”: explaining the predictions of any classifier. In: Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, KDD 2016. Association for Computing Machinery, New York (2016)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Simonovsky, M., Komodakis, N.: Dynamic edge-conditioned filters in convolutional neural networks on graphs. In: Proceedings - 30th IEEE Conference on Computer Vision and Pattern Recognition, CVPR 2017 (2017)
Sundararajan, M., Taly, A., Yan, Q.: Axiomatic attribution for deep networks. In: Precup, D., Teh, Y.W. (eds.) Proceedings of the 34th International Conference on Machine Learning. Proceedings of Machine Learning Research, vol. 70, pp. 3319–3328. PMLR (06–11 Aug 2017)
Unal, I.: Defining an optimal cut-point value in ROC analysis: An Alternative Approach. In: Computational and Mathematical Methods in Medicine (2017)
Valette, S., Chassery, J.M.: Approximated centroidal voronoi diagrams for uniform polygonal mesh coarsening. In: Computer Graphics Forum (2004)
Vedaldi, A., Soatto, S.: Quick shift and kernel methods for mode seeking. In: Forsyth, D., Torr, P., Zisserman, A. (eds.) ECCV 2008. LNCS, vol. 5305, pp. 705–718. Springer, Heidelberg (2008). https://doi.org/10.1007/978-3-540-88693-8_52
Yezzi, A.J., Prince, J.L.: An Eulerian PDE approach for computing tissue thickness. IEEE Trans. Med. Imaging (2003)
Zhang, X.M., Liang, L., Liu, L., Tang, M.J.: Graph neural networks and their current applications in bioinformatics. Front. Genet. (2021)
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Ly, B. et al. (2022). Interpretable Prediction of Post-Infarct Ventricular Arrhythmia Using Graph Convolutional Network. In: Camara, O., et al. Statistical Atlases and Computational Models of the Heart. Regular and CMRxMotion Challenge Papers. STACOM 2022. Lecture Notes in Computer Science, vol 13593. Springer, Cham. https://doi.org/10.1007/978-3-031-23443-9_15
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