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Catecholamines and Immunomodulation

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Neuroendocrine-Immune System Interactions

Part of the book series: Masterclass in Neuroendocrinology ((MANEURO,volume 13))

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Abstract

Dopamine, norepinephrine, and epinephrine are endogenous catecholamines, known to play many different roles in the body, such as increasing heart rate, blood pressure, and blood glucose, controlling movement, and acting on mood and behavior. Catecholamines were first described as neurotransmitters of the sympathetic nervous system, but they also act as hormones released by the adrenal medulla, and increasing evidence indicates their crucial role in the immune system. In this chapter, we will describe how catecholamines modulate immune cells in physiologic as well as pathologic conditions and provide evidence indicating that catecholamines are also to be considered cytokines, that is compounds synthesized by immune cells, which act as local intercellular signaling mediators. We will then describe how this knowledge will be helpful for new therapeutic strategies.

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  1. Department of Immunology, IfADo-Leibniz Research Centre for Working Environment and Human Factors, Research Group of Neuroimmunology, Dortmund, Germany

    Maren Claus & Silvia Capellino

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  1. Maren Claus
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  1. CNRS UMR5164 ImmunoConcept, University of Bordeaux, Bordeaux, France

    Jan Pieter Konsman

  2. College of Medicine, University of Cincinnati, Cincinnati, OH, USA

    Teresa M. Reyes

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Claus, M., Capellino, S. (2023). Catecholamines and Immunomodulation. In: Konsman, J.P., Reyes, T.M. (eds) Neuroendocrine-Immune System Interactions. Masterclass in Neuroendocrinology, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-031-21358-8_5

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