Abstract
Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate, whose etiology remains largely unknown. It mainly concerns women and is characterized notably by a voluntary food restriction leading to a state of undernutrition often associated with excessive physical activity. Despite specialized care, relapse is common and affects approximately 40% of patients. AN is comorbid with several other psychiatric diseases such as depression, anxiety, or compulsivity. Patients suffering from AN also present autonomic, immune, metabolic, and neuroendocrine alterations that participate in the worsening of the disease. We describe here how the autonomic and hormonal systems, main contributors to the brain-body homeostasis, participate directly or indirectly in the modulation of the immune system in AN. The complexity of the interactions between these processes reflects the complexity of AN. The understanding of such complexity could help adjust procedures to personalize medical approaches, integrating the diversity of factors leading to AN manifestations.
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De Zorzi, L., Ranfaing, S., Sequeira, H., Viltart, O. (2023). Autonomic, Immune, Metabolic, and Neuroendocrine Dimensions of Anorexia Nervosa: An Integrative View. In: Konsman, J.P., Reyes, T.M. (eds) Neuroendocrine-Immune System Interactions. Masterclass in Neuroendocrinology, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-031-21358-8_14
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