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Comparison of Numerical Model with Experimental Measurements for the Purpose of Testing Partially and Fully Biodegradable Stents

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Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications

Part of the book series: Engineering Materials ((ENG.MAT.))

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Abstract

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the arterial wall. This accumulation produces plaque in the arteries. Percutaneous transluminal coronary angioplasty (PTCA) is a minimally invasive procedure that opens narrowed coronary arteries because of the plaque growth. A medical device that can hold an artery open in the area of narrowing is called a stent and it usually resembles a mesh tube. Mechanical stent tests are standard preclinical procedure used to simulate stent behavior for different physiological conditions. In this research, a mechanical test called three-point bending test was performed on a partially and fully bioresorbable vascular scaffold (BVS) manufactured by Boston Scientific Limited [1]. Poly-l-lactic acid (PLLA) material model was implemented for the numerical model inside in-house PAK [2] software. Measurements obtained by mechanical testing were compared with the numerical results. There is a strong correlation between the numerical simulation and real experiments with a coefficient of determination (R2) > 0.99 and a correlation coefficient (R) > 0.99. It can be concluded that in silico mechanical tests can partially or fully replace in vitro stent tests, which can open a new avenue for regulatory submission and change regulatory ISO standard procedures.

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Acknowledgements

This study was funded by the European Project H2020 InSilc [grant number 777119] and Serbian Ministry of Education, Science, and Technological Development [451-03-68/2020-14/200107 (Faculty of Engineering, University of Kragujevac). This chapter reflects only the author’s view. The Commission is not responsible for any use that may be made of the information it contains.

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Authors and Affiliations

  1. Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia

    Nenad Filipović

  2. Biomedical Research and Development Center, BioIRC, Kragujevac, Serbia

    Nenad Filipović

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  1. Nenad Filipović
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Correspondence to Nenad Filipović .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, University of Niš, Niš, Serbia

    Stevo Najman

  2. (Deceased), Niš, Serbia

    Vojislav Mitić

  3. Department of Biomedical Materials, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

    Thomas Groth

  4. BerlinAnalytix GmbH, Berlin, Germany

    Mike Barbeck

  5. Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan

    Po-Yu Chen

  6. School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD, Australia

    Ziqi Sun

  7. Department of Mathematics, Faculty of Electronic Engineering, University of Niš, Niš, Serbia

    Branislav Randjelović

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Filipović, N. (2023). Comparison of Numerical Model with Experimental Measurements for the Purpose of Testing Partially and Fully Biodegradable Stents. In: Najman, S., et al. Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-031-17269-4_11

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