Cardiovascular Surgery in the Elderly

  • Chapter
  • First Online:
Cardiovascular Disease in the Elderly

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 679 Accesses

Abstract

The elderly represent a prominent, with improving life expectancies, rapidly expanding sector of the US population, with currently over 13 million people, and estimates that this number will quadruple in the next 50 years. [1, 2]. In large part, these demographic trends are attributable to improved modalities for preventing and managing cardiovascular disease (CVD) in young and middle-aged adults, which improved survival and delayed the onset of CVD until later in life. These improvements have resulted in an increase in the prevalence of CVD in the population and the incidence of CVD in older adults [3, 4]. CVD remains the leading cause of morbidity and mortality in the elderly, despite advances in medical therapies [5–8]. Elderly patients are thus undergoing more procedures to treat CVD, and the demographics of patients undergoing cardiac surgery, a validated means of increasing survival and improving quality of life, reflect this trend [9]. Compared to a younger cohort, the elderly population generally has higher rates of comorbid disease with lower functional reserve, ultimately predisposing them to a higher risk of complications and death. This increased risk, paired with the institutional and societal emphasis on procedural outcomes, has led many cardiologists and cardiac surgeons to only reluctantly recommend cardiac operations for elderly patients. With the advancement and proliferation of percutaneous technologies, many cardiac surgeons are nonetheless operating on older, sicker patients compared to their training and initial practice. For example, elderly patients comprise an increasingly prominent proportion of the population undergoing coronary artery bypass grafting (CABG), and the number of octogenarians undergoing CABG in the United States increased by 67% from 1987 to 1990 [10–12]. There has been a corresponding increase in the literature investigating the CABG outcomes for septuagenarians, octogenarians, and nonagenarians with varied conclusions due to small sample sizes and divergent institutional experiences [3, 5, 6, 10, 11, 13–16]. Regardless of this variance, most of the literature demonstrates that, despite increased costs and longer lengths of stay, cardiac operations can be performed with acceptable hospital mortality rates in carefully selected elderly patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now
Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 85.59
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 106.99
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
EUR 149.79
Price includes VAT (Germany)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. U.S. Census Bureau. Population projections program. Washington, DC: U.S. Census Bureau; 2000.

    Google Scholar 

  2. U.S. Census Bureau. Statistical abstract of the United States: 2000. Washington, DC: U.S. Bureau of the Census; 2000. p. 85.

    Google Scholar 

  3. Roberts WC, Shirani J. Comparison of cardiac findings at necropsy in octogenarians, nonagenarians, and centenarians. Am J Cardiol. 1998;82:627–31.

    Article  CAS  Google Scholar 

  4. Foot DK, et al. Demography and cardiology, 1950–2050. J Am Coll Cardiol. 2000;35(4):1076–81.

    Article  Google Scholar 

  5. Craver JM, et al. 601 octogenarians undergoing cardiac surgery: outcome and comparison with younger age groups. Ann Thorac Surg. 1999;67:1104–10.

    Article  CAS  Google Scholar 

  6. Tsai TP, et al. Aortocoronary bypass surgery in septuagenarians and octogenarians. J Cardiovasc Surg. 1989;30:364–8.

    CAS  Google Scholar 

  7. Weintraub WS, et al. Influence of age on results of coronary artery surgery. Circulation. 1991;84(Suppl 3):226–35.

    Google Scholar 

  8. Ko W, et al. Isolated coronary artery bypass grafting in one hundred consecutive octogenarian patients: a multivariate analysis. J Thorac Cardiovasc Surg. 1991;102:532–8.

    Article  CAS  Google Scholar 

  9. Kumar P, et al. Quality of life in octogenarians after open heart surgery. Chest. 1995;108:919–26.

    Article  CAS  Google Scholar 

  10. Engoren M, et al. Cost, outcome, and functional status in octogenarians and septuagenarians after cardiac surgery. Chest. 2002;122:1309–15.

    Article  Google Scholar 

  11. Peterson ED, Cowper PA, Jollis JG. Outcomes of coronary artery bypass surgery in 24461 patients aged 80 years or older. Circulation. 1995;92(Suppl II):II-85–95.

    Article  CAS  Google Scholar 

  12. Peterson ED, et al. Changing mortality following myocardial revascularization in the elderly: the national Medicare experience. Ann Int Med. 1994;1212:919–27.

    Article  Google Scholar 

  13. Smith KM, et al. Outcomes and costs of coronary artery bypass grafting: comparison between octogenarians and septuagenarians at a tertiary care center. CMAJ. 2001;165(6):759–64.

    CAS  Google Scholar 

  14. Mullaney CJ, et al. Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older. Circulation. 1991;82(Suppl IV):IV229–36.

    Google Scholar 

  15. Glower DD, Christopher TD, Milano CA. Performance status and outcome after coronary artery bypass grafting in persons 80 to 93 years. Am J Cardiol. 1992;70:567–71.

    Article  CAS  Google Scholar 

  16. Alexander KP, et al. Outcomes of cardiac surgery in patients age > 80 years: results from the National Cardiovascular Network. J Am Coll Cardiol. 2000;35:731–8.

    Article  CAS  Google Scholar 

  17. Tseng EE, et al. Aortic valve replacement in the elderly. Ann Surgery. 1997;225(6):793–804.

    Article  CAS  Google Scholar 

  18. Gudbjartsson T, Aranki S, Cohn LH. Mechanical/bioprosthetic mitral valve replacement. In: Edmunds Jr HL, editor. Cardiac surgery in the adult. New York: McGraw-Hill; 2003. p. 951–86.

    Google Scholar 

  19. Desai ND, Christakis GT. Stented mechanical/bioprosthetic aortic valve replacement. In: Edmunds Jr HL, editor. Cardiac surgery in the adult. New York: McGraw-Hill; 2003. p. 825–55.

    Google Scholar 

  20. Khan NE, et al. A randomized comparison of off-pump and on-pump multivessel coronary artery bypass surgery. N Engl J Med. 2004;350(1):21–8.

    Article  CAS  Google Scholar 

  21. Legare JF, et al. Coronary bypass surgery performed off pump does not result in lower in-hospital morbidity than coronary artery bypass grafting performed on pump. Circulation. 2004;109(7):810–2.

    Article  Google Scholar 

  22. Racz MJ, Hannan EL, Isom OW. A comparison of short- and long-term outcomes after off-pump and on-pump coronary artery bypass surgery with sternotomy. J Am Coll Cardiol. 2004;43(4):557–64.

    Article  Google Scholar 

  23. Kolh P, et al. Cardiac surgery in octogenarians: perioperative outcome and longterm results. Eur Heart J. 2001;22:1235–43.

    Article  CAS  Google Scholar 

  24. Neri E, et al. Operation for acute type a aortic dissection in octogenarians: is it justified? J Thorac Cardiovasc Surg. 2001;121:259–67.

    Article  CAS  Google Scholar 

  25. Durand DJ, et al. Mandatory versus selective preoperative carotid screening: a retrospective analysis. Ann Thorac Surg. 2004;77:TBD.

    Google Scholar 

  26. Naylor AR, et al. Carotid artery disease and stroke during coronary artery bypass: a critical review of the literature. Eur J Vasc Endovasc Surg. 2002;23(4):283–94.

    Article  CAS  Google Scholar 

  27. Gold JP, et al. Improvement of outcomes after coronary artery bypass: a randomized trial comparing intraoperative high versus low mean arterial pressure. J Thorac Cardiovasc Surg. 1995;110(5):1302–11.

    Article  CAS  Google Scholar 

  28. Floyd TF, et al. Perioperative changes in cerebral blood flow after cardiac surgery: influence of anemia and aging. Ann Thorac Surg. 2003;76(6):2037–42.

    Article  Google Scholar 

  29. Wu WC, et al. Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med. 2001;345(17):1230–6.

    Article  CAS  Google Scholar 

  30. Bacchetta MD, et al. Outcomes of cardiac surgery in nonagenarians: a 10-year experience. Ann Thorac Surg. 2002;75:1215–20.

    Article  Google Scholar 

  31. Van der Mast RC. Delirium after cardiac surgery. PhD Dissertation 1994.

    Google Scholar 

  32. Van der Mast RC, et al. Incidence of and preoperative predictors for delirium after cardiac surgery. J Psychosom Res. 1998;46(5):479–83.

    Article  Google Scholar 

  33. Rolfson DB, et al. Incidence and risk factors for delirium and other adverse outcomes in older adults after coronary artery bypass graft surgery. Can J Cardiol. 1999;15(7):771–6.

    CAS  Google Scholar 

  34. Bitondo Dyer C, Ashton CM, Teasdale TA. Postoperative delirium: a review of 80 primary data-collection studies. Arch Intern Med. 1995;155:461–5.

    Article  Google Scholar 

  35. Gokgoz L, et al. Psychiatric complications of cardiac surgery: postoperative delirium syndrome. Scand Cardiovasc J. 1997;31:217–22.

    Article  CAS  Google Scholar 

  36. Meagher DJ. Delirium: optimising management. BMJ. 2001;322:144–9.

    Article  CAS  Google Scholar 

  37. Bayindir O, et al. The use of the 5-HT3-receptor antagonist ondansetron for the treatment of postcardiotomy delirium. J Cardiothorac Vasc Anesth. 2000;14(3):288–92.

    Article  CAS  Google Scholar 

  38. Taylor HL, et al. A questionnaire for the assessment of leisure-time physical activities. J Chronic Dis. 1978;31:745–55.

    Article  Google Scholar 

  39. Salazar JD, et al. Stroke after cardiac surgery: short and long-term outcomes. Ann Thorac Surg. 2001;72:1195–202.

    Article  CAS  Google Scholar 

  40. Coelho PNMP, Miranda LMRPC, Barros PMP, Fragata JIG. Quality of life after elective cardiac surgery in elderly patients. Interact Cardiovasc Thorac Surg. 2019;28(2):199–205. https://doi.org/10.1093/icvts/ivy235.

    Article  Google Scholar 

  41. Krumholz HM, Herrin J. Quality improvement studies: the need is there but so are the challenges. Am J Med. 2000;109:501–3.

    Article  CAS  Google Scholar 

  42. Gersh BJ, Kronmal RA, Frye RL. Coronary arteriography and coronary artery bypass surgery; morbidity and mortality in patients aged 65 years or older: a report from the coronary artery surgery study. Circulation. 1983;67:483–91.

    Article  CAS  Google Scholar 

  43. Newman AB, et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Scie Med Sci. 2001;56(3):M158–66.

    Article  CAS  Google Scholar 

  44. Fried LP, et al. Risk factors for 5-year mortality in older adults: the cardiovascular health study. JAMA. 1998;279(8):585–92.

    Article  CAS  Google Scholar 

  45. Pendergast DR, Fisher NM, Calkins E. Cardiovascular, neuromuscular, and metabolic alterations with age leading to frailty. J Gerontol. 1993;48:61–7.

    Article  Google Scholar 

  46. Fried LP, et al. Physical disability in older adults: a physiologic approach. Cardiovascular health study research group. Clin Epidemiol. 1994;47(7):747–60.

    Article  CAS  Google Scholar 

  47. Bild DE, et al. Age-related trends in cardiovascular morbidity and physical functioning in the elderly: the cardiovascular health study. J Am Geriatr Soc. 1993;41(10):1047–56.

    Article  CAS  Google Scholar 

  48. Fried LP, Walston J. Frailty and failure to thrive. In: Hazzard WR, et al., editors. Principles of geriatric medicine and gerontology. New York: McGraw-Hill; 1998. p. 1387–402.

    Google Scholar 

  49. Rockwood K, et al. A brief clinical instrument to classify frailty in elderly people. Lancet. 1999;353:205–6.

    Article  CAS  Google Scholar 

  50. Winograd CH, et al. Screening for frailty: criteria and predictors of outcomes. J Am Geriatr Soc. 1991;39:778–84.

    Article  CAS  Google Scholar 

  51. Campbell AJ, Buchner DM. Unstable disability and the fluctuations of frailty. Age Aging. 1997;26:315–8.

    Article  CAS  Google Scholar 

  52. Winograd CH. Targeting strategies: an overview of criteria and outcomes. J Am Geriatr Soc. 1991;39S:25S–35S.

    Article  Google Scholar 

  53. Buchner DM, Wagner EH. Preventing frail health. Clin Geriatr Med. 1992;8:1–17.

    Article  CAS  Google Scholar 

  54. Bortz WM II. A conceptual framework of frailty: a review. J Gerontol A Biol Sci Med Sci. 2002;57(5):M283–8.

    Article  Google Scholar 

  55. Fried LP, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Scie Med Sci. 2001;56(3):M146–56.

    Article  CAS  Google Scholar 

  56. Walston J, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the cardiovascular health study. Arch Intern Med. 2002;162(20):2333–41.

    Article  Google Scholar 

  57. Zieman SJ, et al. Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to L-arginine. Circ Res. 2001;88:97–102.

    Article  CAS  Google Scholar 

  58. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245–70.

    Article  CAS  Google Scholar 

  59. Miguelena-Hycka J, Lopez-Menendez J, Prada PC, García MM, Vigil-Escalera C, Harmand MG, Pérez RM, Rodriguez-Roda J. Changes in frailty status after cardiac surgery. A prospective cohort study Arch Gerontol Geriatr. 2022;98:104568. https://doi.org/10.1016/j.archger.2021.104568. Epub 2021 Nov 9

    Article  Google Scholar 

  60. Jha SR, Hannu MK, Newton PJ, Wilhelm K, Hayward CS, Jabbour A, et al. Reversibility of frailty after bridge-to-transplant ventricular assist device implantation or heart transplantation. Transplant Direct. 2017;3(7):E167.

    Article  Google Scholar 

  61. Plomondon ME, et al. Off-pump coronary artery bypass is associated with improved risk-adjusted outcomes. Ann Thorac Surg. 2001;72(1):114–9.

    Article  CAS  Google Scholar 

  62. Habertheuer A, Aranda-Michel E, Schindler J, Gleason TG, Kilic A, Kliner D, Bianco V, Toma C, Sultan I. Longitudinal outcomes of nonagenarians undergoing transcatheter aortic valve replacement. Ann Thorac Surg. 2021;111(5):1520–8.

    Article  Google Scholar 

  63. Hoogma DF, Venmans E, Al Tmimi L, Tournoy J, Verbrugghe P, Jacobs S, Fieuws S, Milisen K, Adriaenssens T, Dubois C, Rex S. Postoperative delirium and quality of life after transcatheter and surgical aortic valve replacement: a prospective observational study. J Thorac Cardiovasc Surg. 2021; https://doi.org/10.1016/j.jtcvs.2021.11.023. Epub ahead of print

  64. Strom JB, Xu J, Orkaby AR, Shen C, Song Y, Charest BR, Kim DH, Cohen DJ, Kramer DB, Spertus JA, Gerszten RE, Yeh RW. The role of frailty in identifying benefit from transcatheter versus surgical aortic valve replacement. Circ Cardiovasc Qual Outcomes. 2021;14(12):e008566. https://doi.org/10.1161/CIRCOUTCOMES.121.008566. Epub ahead of print

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David D. Yuh .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Blitzer, D., Yuh, D.D. (2023). Cardiovascular Surgery in the Elderly. In: Leucker, T.M., Gerstenblith, G. (eds) Cardiovascular Disease in the Elderly. Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-031-16594-8_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-16594-8_8

  • Published:

  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-031-16593-1

  • Online ISBN: 978-3-031-16594-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation