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Metal-Organic Framework Composite-Based Biosensors: Biomedical Applications

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  • First Online:
Handbook of Nanosensors

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Abstract

Metal-organic frameworks (MOFs) are a novel type of crystalline material that boasts a range of uses across fields such as catalysis, biomedical engineering, microporous conductors, separation, and electrochemical biosensors. Thanks to their stability, tunable compositions and structures, and high porosity, MOFs are an excellent choice for crafting a diverse array of biosensors. Their unique properties, including strong fluorescence, chemical functionality, and affinity for probes such as DNA, aptamers, or antibodies, make them promising materials for use as biosensor platforms or electrode materials. These properties enable MOFs to detect biomedical analytes selectively and sensitively. Through coupling with different techniques such as electrochemical, fluorescence, and colorimetric methods, MOF-based materials showed promising applications for detecting various analytes. Regardless of their applications in the biomedical field, MOF-based biosensors are expected to pave the way for biochemical and food safety monitoring. Beyond that, this comprehensive chapter provides new insights into the construction of biosensors with MOF-based materials for biomedical applications.

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Abbreviations

AED:

Anodic electrodeposition

AuNPs:

Gold nanoparticles

BSA:

Bovine serum albumin

C2H6S:

Dimethyl sulfide

CED:

Cathodic electrodeposition

CH4S:

Methyl mercaptan

cTnI:

Cardiac troponin I

CV:

Cyclic voltammetry

DPV:

Differential pulse voltammetry

EC:

Electrochemical

ECL:

Electrochemiluminescence

EPD:

Electrophoretic deposition

FET:

Field-effect transistor

FTIR:

Fourier transform infrared spectroscopy

GCE:

Glassy carbon electrode

H2S:

Hydrogen sulfide

HCV-RNA:

Hepatitis C virus ribonucleic acid

HRP:

Horseradish peroxidase

LOD:

Limit of detection

MD:

Maduramicin

MNPs:

Metal nanoparticles

MOFs:

Metal-organic frameworks

N-CNTs:

Nitrogen-doped carbon nanotubes

NF:

Nickel foam

NLM:

Nilutamide

NPs:

Nanoparticles

OXAL:

Oxaliplatin

PNK:

Polynucleotide kinase

POCT:

Point-of-care testing

RT-PCR:

Real-time polymerase chain reaction

SERS:

Surface-enhanced Raman scattering

SPE:

Screen-printed electrode

ssDNA:

Single-stranded DNA

SWV:

Square wave voltammetry

TMB:

3,3′,5,5′-Tetramethylbenzidine

TOB:

Tobramycin

ULS:

Ultrasound-assisted synthesis

VP:

Vibrio parahaemolyticus

VSCs:

Volatile sulfur compounds

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Authors and Affiliations

  1. Biology and Chemistry Department, Faculty of Sciences and Techniques, Hassan II University of Casablanca, Casablanca, Morocco

    Dounia Elfadil

  2. Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt

    Gharieb S. El-Sayyad

  3. Department of Microbiology & Immunology, Faculty of Pharmacy, Galala University, New Galala City, Suez, Egypt

    Gharieb S. El-Sayyad

  4. Chemistry Department, Faculty of Science, Al–Azhar University, Assiut, Egypt

    Gomaa A. M. Ali

  5. Faculty of Advanced Basic Science, Galala University, Suez, Egypt

    Gomaa A. M. Ali

  6. New Assiut Technological University, New Assiut City, Assiut, Egypt

    Gomaa A. M. Ali

  7. Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt

    Gharieb S. El-Sayyad

Authors
  1. Dounia Elfadil
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  2. Gharieb S. El-Sayyad
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  3. Gomaa A. M. Ali
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Corresponding authors

Correspondence to Gharieb S. El-Sayyad or Gomaa A. M. Ali .

Editor information

Editors and Affiliations

  1. Chemistry Department, Al-Azhar University, Assiut, Egypt

    Gomaa A. M. Ali

  2. Fac. of Industrial Sciences & Technology, Universiti Malaysia Pahang, Pekan, Malaysia

    Kwok Feng Chong

  3. Advanced Materials Research, Stanley Black & Decker Inc, New Britain, CT, USA

    Abdel Salam H. Makhlouf

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Elfadil, D., El-Sayyad, G.S., Ali, G.A.M. (2024). Metal-Organic Framework Composite-Based Biosensors: Biomedical Applications. In: Ali, G.A.M., Chong, K.F., Makhlouf, A.S.H. (eds) Handbook of Nanosensors. Springer, Cham. https://doi.org/10.1007/978-3-031-16338-8_40-1

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  • DOI: https://doi.org/10.1007/978-3-031-16338-8_40-1

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  • Print ISBN: 978-3-031-16338-8

  • Online ISBN: 978-3-031-16338-8

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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