Abstract
Neurons in the inferior olive nucleus, the sole origin of cerebellar climbing fibers, project their axons to the cerebellum through the olivocerebellar tract. A single olivocerebellar axon gives rise to multiple climbing fibers (about seven in rats), which often terminate into a single longitudinal compartment defined by the cerebellar cortex’s longitudinal striped molecular expression pattern. According to an intriguing topographic relationship, axons originating from a subarea of the inferior olive project to a particular compartment. As a result of this topographic arrangement, the olivocerebellar projection relays synchronous activity of the electrically coupled adjacent inferior olive neurons to complex spike firing of Purkinje cells in a longitudinal compartment. Olivocerebellar axons show a dynamic morphogenetic process. An immature axon has abundant terminal branches that innervate many Purkinje cells. Several terminal branches (climbing fibers) grow to eventually establish a powerful one-to-one synaptic connection between a single climbing fiber terminal and a single target Purkinje cell. Furthermore, these axons are capable of strong compensatory re-innervation after lesion, even in the adult.
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References
Aoki H, Sugihara I (2012) Morphology of single olivocerebellar axons in the denervation–reinnervation model produced by subtotal lesion of the rat inferior olive. Brain Res 1449:24–37
Biswas MS, Luo Y, Sarpong GA, Sugihara I (2019) Divergent projections of single pontocerebellar axons to multiple cerebellar lobules in the mouse. J Comp Neurol 527:1966–1985
Blenkinsop TA, Lang EJ (2011) Synaptic action of the olivocerebellar system on cerebellar nuclear spike activity. J Neurosci 31:14708–14720
Brochu G, Maler L, Hawkes R (1990) Zebrin II: a polypeptide antigen expressed selectively by Purkinje cells reveals compartments in rat and fish cerebellum. J Comp Neurol 291:538–552
Chédotal A, Sotelo C (1992) Early development of olivocerebellar projections in the fetal rat using CGRP immunocytochemistry. Eur J Neurosci 4:1159–1179
Dixon KJ, Sherrard RM (2006) Brain-derived neurotrophic factor induces post-lesion transcommissural growth of olivary axons that develop normal climbing fibers on mature Purkinje cells. Exp Neurol 202:44–56
Eccles JC, Llinás R, Sasaki K (1966) The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J Physiol 182:268–296
Fujita H, Sugihara I (2012) FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex. J Comp Neurol 520:656–677
Fujita H, Morita N, Furuichi T, Sugihara I (2012) Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration. J Neurosci 32:15688–15703
Fujita H, Aoki H, Ajioka I, Yamazaki M, Abe M, Oh-Nishi A, Sakimura K, Sugihara I (2014) Detailed expression pattern of aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice. PLoS One 9:e86679
Fujita H, Kodama T, du Lac S (2020) Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis. Elife 9:e58613
Horn KM, Pong M, Gibson AR (2010) Functional relations of cerebellar modules of the cat. J Neurosci 30:9411–9423
Lang EJ, Sugihara I, Welsh JP, Llinás R (1999) Patterns of spontaneous complex spike activity in the awake rat. J Neurosci 19:2728–2739
Leznik E, Llinás R (2005) Role of gap junctions in synchronized neuronal oscillations in the inferior olive. J Neurophys 94:2447–2456
Llinás R, Yarom Y (1986) Oscillatory properties of guinea-pig inferior olivary neurones and their pharmacological modulation: an in vitro study. J Physiol 376:163–182
Long MA, Deans MR, Paul DL, Connors BW (2002) Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci 22:10898–10905
Marthy A, Ho SSN, Davie JT, Duguid IC, Clark BA, Häusser M (2009) Encoding of oscillations by axonal bursts in inferior olive neurons. Neuron 62:388–399
Ramón y Cajal S (1911) Histologie du système nerveux de l’homme et des verébrés, vol 2. Maloine, Paris
Rossi F, Wiklund L, Van der Want JJL, Strata P (1991) Reinnervation of cerebellar Purkinje cells by climbing fibers surviving a subtotal lesion of the inferior olive in the adult rat. I. Development of new collateral branches and terminal plexuses. J Comp Neurol 308:513–535
Ruigrok TJ (2011) Ins and outs of cerebellar modules. Cerebellum 10:464–474
Ruigrok TJ, Voogd J (1990) Cerebellar nucleo-olivary projections in the rat: an anterograde tracing study with Phaseolus vulgaris leucoagglutinin (PHA-L). J Comp Neurol 298:315–333
Sasaki K, Bower JM, Llinás R (1989) Multiple Purkinje cell recording in rodent cerebellar cortex. Eur J Neurosci 1:572–586
Sugihara I (2005) Microzonal projection and climbing fiber remodeling in single olivocerebellar axons of new born rats at postnatal days 4–7. J Comp Neurol 487:93–106
Sugihara I, Quy PN (2007) Identification of aldolase C compartments in the mouse cerebellar cortex by olivocerebellar labeling. J Comp Neurol 500:1076–1092
Sugihara I, Shinoda Y (2004) Molecular, topographic and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labelling. J Neurosci 24:8771–8785
Sugihara I, Shinoda Y (2007) Molecular, topographic and functional organization of the cerebellar nuclei: analysis by three-dimensional map** of the olivonuclear projection and aldolase C labeling. J Neurosci 27:9696–9710
Sugihara I, Lang EJ, Llinás R (1993) Uniform olivocerebellar conduction time underlies Purkinje cell complex spike synchronicity in the rat cerebellum. J Physiol Lond 470:243–271
Sugihara I, Wu H-S, Shinoda Y (1999) Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat. J Comp Neurol 414:131–148
Sugihara I, Bailly Y, Mariani J (2000) Olivocerebellar climbing fibers in the granuloprival cerebellum: morphological study of individual axonal projections in the X-irradiated rat. J Neurosci 20:3745–3760
Sugihara I, Wu H-S, Shinoda Y (2001) The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to cerebellar compartmentalization. J Neurosci 21:7715–7723
Sugihara I, Lohof AM, Letellier M, Mariani J, Sherrard RM (2003) Post-lesion transcommissural growth of olivary climbing fibres creates functional synaptic microzones. Eur J Neurosci 18:3027–3036
Sugihara I, Ebata S, Shinoda Y (2004) Functional compartmentalization in the flocculus and the ventral dentate and dorsal group y nuclei: an analysis of single olivocerebellar axonal morphology. J Comp Neurol 470:113–133
Sugihara I, Marshall SP, Lang EJ (2007) Relationship of complex spike synchrony bands and climbing fiber projection determined by reference to aldolase C compartments in crus IIa of the rat cerebellar cortex. J Comp Neurol 501:13–29
Sugihara I, Fujita H, Na J, Quy PN, Li BY, Ikeda D (2009) Projection of reconstructed single Purkinje cell axons in relation to the cortical and nuclear aldolase C compartments of the rat cerebellum. J Comp Neurol 512:282–304
Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K (2019) Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. eLife 8:e47021
Voogd J, Bigaré F (1980) Topographical distribution of olivary and corticonuclear fibers in the cerebellum: a review. In: Courville J, de Montigny C, Lamarre Y (eds) The inferior olivary nucleus anatomy and physiology. Raven Press, New York, pp 207–234
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Luo, Y., Sugihara, I. (2023). The Olivocerebellar Tract. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_6
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DOI: https://doi.org/10.1007/978-3-031-15070-8_6
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