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The Cerebellar Neuroimmune System

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Essentials of Cerebellum and Cerebellar Disorders

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Abstract

Emerging research has revealed that glial cells of the brain can produce many of the same signaling factors as cells of the peripheral immune system and, as such, can function as a brain immune system, referred to as the neuroimmune system. Both neurons and glial cells of the brain express receptors and intracellular signaling pathways that can interpret the signals communicated by these factors, which are called neuroimmune factors when produced by brain cells, and in response adjust their function. The neuroimmune system serves many roles both in normal brain biology and in brain pathology. To date, the majority of studies on the characteristics and function of the neuroimmune system comes from brain regions outside of the cerebellum, but recent studies of the cerebellum have shown that the neuroimmune system plays an important role in cerebellar development, function, and disease. This new and expanding area of research will likely bring greater understanding to the cellular and molecular mechanisms that mediate cerebellar function.

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Authors and Affiliations

  1. Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA

    Donna L. Gruol

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  1. Donna L. Gruol
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Correspondence to Donna L. Gruol .

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Editors and Affiliations

  1. Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. Service de Neurologie, CHU-Charleroi, Charleroi, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  6. Department of Physiology, Zhejiang University School of Medicine, Hangzho, China

    Ying Shen

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Gruol, D.L. (2023). The Cerebellar Neuroimmune System. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_47

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