Abstract
Polymeric nanoparticles allow drug delivery at the targeted tumor site. Nonetheless, the presence of biological barriers is limiting specific delivery, and there are still few nanodelivery systems available for clinical usage. Here, pH-sensitive polymeric nanoparticles improve the delivery of cargo at the targeted site with improved therapeutic efficacy. Stimulus-responsive nanoparticles have the ability to enhance therapeutic delivery to a single cell or a targeted site. Indeed, stimuli such as changes in pH, redox potential, or the presence of enzymes influence drug release. In addition, the pH of the tumor microenvironment is lower than the pH of the surrounding tissue. Since nanoparticles are internalized into cells by acidified vesicles, pH variation has attracted attention in the synthesis of stimuli-responsive nanoparticles. This chapter reviews techniques employed for develo** pH-responsive nanoparticles and applications for treatment of solid tumors.
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Behera, A., Padhi, S. (2022). pH-Sensitive Polymeric Nanoparticles for Cancer Treatment. In: Padhi, S., Behera, A., Lichtfouse, E. (eds) Polymeric nanoparticles for the treatment of solid tumors. Environmental Chemistry for a Sustainable World, vol 71. Springer, Cham. https://doi.org/10.1007/978-3-031-14848-4_15
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