Abstract
In the current chapter, we will present the various pathophysiological that have the potential to induce CSD-like response. The mechanism of coupling between the availability of oxygen and the development of CSD may involve the leakage of potassium from the intracellular to the extracellular compartment in the cerebral cortex tissue. The interaction between the level of carbon dioxide in the breathing mixture in the hyperbaric chamber will be demonstrated. Also, the effects of various pharmacological agents on the development of CSD will be presented and discussed.
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References
Back, T., Kohno, K., & Hossmann, K. A. (1994). Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: Effect on blood flow, tissue oxygenation, and electroencephalogram. Journal of Cerebral Blood Flow and Metabolism, 14, 12–19.
Bardt, T. F., Unterberg, A. W., Hartl, R., Kiening, K. L., Schneider, G. H., & Lanksch, W. R. (1998). Monitoring of brain tissue PO2 in traumatic brain injury: Effect of cerebral hypoxia on outcome. Acta Neurochirurgica. Supplement, 71, 153–156.
Barlow, C. H., & Chance, B. (1976). Ischemic areas in perfused rat hearts: Measurement by NADH fluorescence photography. Science, 193, 909–910.
Bean, J. W., & Leatherman, N. E. (1969). Cerebral blood flow during convulsions. Alterations induced in animals by high pressure oxygen. Archives of Neurology, 20, 396–405.
Bean, J. W., Lignell, J., & Burgess, D. W. (1972). Cerebral O2, CO2, regional cerebral vascular control, and hyperbaric oxygenation. Journal of Applied Physiology, 32, 650–657.
Benveniste, H., Jorgensen, M. B., Diemer, N. H., & Hansen, A. J. (1988). Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia. Acta Neurologica Scandinavica, 78, 529–536.
Bergsneider, M., Hovda, D. A., Lee, S. M., Kelly, D. F., McArthur, D. L., Vespa, P. M., Lee, J. H., Huang, S. C., Martin, N. A., Phelps, M. E., & Becker, D. P. (2000). Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury. Journal of Neurotrauma, 17, 389–401.
Bouma, G. J., Muizelaar, J. P., Choi, S. C., Newlon, P. G., & Young, H. F. (1991). Cerebral circulation and metabolism after severe traumatic brain injury: The elusive role of ischemia. Journal of Neurosurgery, 75, 685–693.
Brown, J. A., Preul, M. C., & Taha, A. (1988). Hyperbaric oxygen in the treatment of elevated intracranial pressure after head injury. Pediatric Neuroscience, 14, 286–290.
Bullock, R., Zauner, A., Woodward, J. J., Myseros, J., Choi, S. C., Ward, J. D., Marmarou, A., & Young, H. F. (1998). Factors affecting excitatory amino acid release following severe human head injury. Journal of Neurosurgery, 89, 507–518.
Bures, J. (1957). The effect of anoxia and asphyxia on spreading EEG depression. Physiologia Bohemoslovenica, 6, 447–453.
Bures, J., & Buresova, O. (1960). Activation of latent foci of spreading cortical depression in rats. Journal of Neurophysiology, 23, 225–236.
Chance, B. (1966). The identification and control of metabolic states. Genootschap ter Bevordering van Natuur-, Genees-, en Heelkunde te Amsterdam, 5–37.
Chance, B. (1967). Non-destructive readout of biochemical data. Williams and Wilkins.
Chance, B., & Williams, G. R. (1955). Respiratory enzymes in oxidative phosphorylation (I- kinetics of oxygen utilization). The Journal of Biological Chemistry, 217, 383–393.
Chance, B., Jamieson, D., & Coles, H. (1965). Energy-linked pyridine nucleotide reduction: Inhibitory effects of hyperbaric oxygen in vitro and in vivo. Nature, 4981, 257–263.
Chance, B., Jamieson, D., & Williamson, J. R. (1966). Control of the oxidation-reduction state of reduced pyridine nucleotides in vivo and in vitro by hyperbaric oxygen, Third international conference on hyperbaric medicine (pp. 15–41). National Academy of Sciences.
Chance, B., Thurman, R. G., & Gosalvez, M. (1969). Oxygen affinities of cellular respiration. Forvarsmedicin, 5, 235–243.
Chance, B., Barlow, C., Haselgrove, J., Nakase, Y., Quistorff, B., Matschinsky, F., & Mayevsky, A. (1978). Microheterogeneities of redox states of perfused and intact organs. In P. Srere (Ed.), Microenvironments and metabolic compartmentation (pp. 131–148). Academic Press.
Chapin, J. L. (1955). Anticonvulsant threshold of CO2 in oxygen under high pressure. Proceedings of the Society for Experimental Biology and Medicine, 90, 663–664.
Crowe, W., Mayevsky, A., & Mela, L. (1977). Application of a solid membrane ion selective electrode to in vivo measurements. The American Journal of Physiology, 233, C56–C60.
Crutchfield, J. S., Narayan, R. K., Robertson, C. S., & Michael, L. H. (1990). Evaluation of a fiberoptic intracranial pressure monitor. Journal of Neurosurgery, 72, 482–487.
Czosnyka, M., Guazzo, E., Whitehouse, M., Smielewski, P., Czosnyka, Z., Kirkpatrick, P., Piechnik, S., & Pickard, J. D. (1996). Significance of intracranial pressure waveform analysis after head injury. Acta Neurochirurgica, 138, 531–541. discussion 541-532.
Dietrich, W. D., Feng, Z. C., Leistra, H., Watson, B. D., & Rosenthal, M. (1994). Photothrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions. Journal of Cerebral Blood Flow and Metabolism, 14, 20–28.
Dixon, C. E., Lyeth, B. G., Povlishock, J. T., Findling, R. L., Hamm, R. J., Marmarou, A., Young, H. F., & Hayes, R. L. (1987a). A fluid percussion model of experimental brain injury in the rat. Journal of Neurosurgery, 67, 110–119.
Dixon, C. E., Lyeth, B. G., Povlishock, J. T., Findling, R. L., Hamm, R. J., Marmarou, A., Young, H. F., & Hayes, R. L. (1987b). A fluid percussion model of experimental brain injury in the rat. Journal of Neurosurgery, 67, 110–119.
Engelborghs, K., Verlooy, J., Van Deuren, B., Van Reempts, J., & Borgers, M. (1997). Intracranial pressure in a modified experimental model of closed head injury. Acta Neurochirurgica. Supplement, 70, 123–125.
Fertziger, A. P., & Ranck, J. B., Jr. (1970). Potassium accumulation in interstitial space during epileptiform seizures. Experimental Neurology, 26, 571–585.
Friedli, C. M., Sclarsky, D. S., & Mayevsky, A. (1982). Multiprobe monitoring of ionic, metabolic, and electrical activities in the awake brain. The American Journal of Physiology, 243, R462–R469.
Gido, G., Kristian, T., Katsura, K., & Siesjo, B. K. (1994a). The influence of repeated spreading depression-induced calcium transients on neuronal viability in moderately hypoglycemic rats. Experimental Brain Research, 97, 397–403.
Gido, G., Kristian, T., & Siesjo, B. K. (1994b). Induced spreading depressions in energy-compromised neocortical tissue: Calcium transients and histopathological correlates. Neurobiology of Disease, 1, 31–41.
Graham, D. I., Adams, J. H., & Doyle, D. (1978). Ischaemic brain damage in fatal non-missile head injuries. Journal of the Neurological Sciences, 39, 213–234.
Graham, D. I., Ford, I., Adams, J. H., Doyle, D., Teasdale, G. M., Lawrence, A. E., & McLellan, D. R. (1989). Ischaemic brain damage is still common in fatal non-missile head injury. Journal of Neurology, Neurosurgery, and Psychiatry, 52, 346–350.
Hansen, A. J. (1985). Effect of anoxia on ion distribution in the brain. Physiological Reviews, 65, 101–148.
Harbig, K., Chance, B., Kovach, A. G. B., & Reivich, M. (1976). In vivo measurement of pyridine nucleotide fluorescence from cat brain cortex. Journal of Applied Physiology, 41, 480–488.
Heinemann, U., & Lux, H. D. (1975). Undershoots following stimulus-induced rises of extracellular potassium concentration in cerebral cortex of cat. Brain Research, 93, 63–76.
Hubschmann, O. R., & Kornhauser, D. (1983). Effects of intraparenchymal hemorrhage on extracellular cortical potassium in experimental head trauma. Journal of Neurosurgery, 59, 289–293.
Ishige, N., Pitts, L. H., Pogliani, L., Hashimoto, T., Nishimura, M. C., Bartkowski, H. M., & James, T. L. (1987). Effect of hypoxia on traumatic brain injury in rats: Part 2. Changes in high energy phosphate metabolism. Neurosurgery, 20, 854–858.
Izquierdo, I., Nasello, A. G., & Marichich, E. S. (1970). Effects of potassium on rat hippocampus: The dependence of hippocampal evoked and seizure activity on extracellular potassium levels. Archives Internationales de Pharmacodynamie et de Thérapie, 187, 318–328.
Janebova, M. (1971). Excitation of Leão’s cortical spreading depression by threshold amounts of electrophoretically applied K+ ions. Physiologia Bohemoslovaca, 20, 447–451.
Jobsis, F. F., O’Connor, M., Vitale, A., & Vreman, H. (1971). Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity. Journal of Neurophysiology, 3465, 735–749.
Kaplan, S. A., & Stein, S. N. (1957). Effects of oxygen at high pressure on the transport of potassium, sodium and glutamate in Guinea pig brain cortex. The American Journal of Physiology, 190, 157–162.
Katayama, Y., Becker, D. P., Tamura, T., & Hovda, D. A. (1990). Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. Journal of Neurosurgery, 73, 889–900.
Kobayashi, S., Nishiki, K., Kaede, K., & Ogata, E. (1971). Optical consequences of blood substitution on tissue oxidation- reduction state microfluorometry. Journal of Applied Physiology, 31, 93–96.
Kochanek, P. M., Marion, D. W., Zhang, W., Schiding, J. K., White, M., Palmer, A. M., Clark, R. S., O’Malley, M. E., Styren, S. D., Ho, C., et al. (1995). Severe controlled cortical impact in rats: Assessment of cerebral edema, blood flow, and contusion volume. Journal of Neurotrauma, 12, 1015–1025.
Koroleva, V. I., & Bures, J. (1996). The use of spreading depression waves for acute and long-term monitoring of the penumbra zone of focal ischemic damage in rats. Proceedings. National Academy of Sciences. United States of America, 93, 3710–3714.
Koura, S. S., Doppenberg, E. M., Marmarou, A., Choi, S., Young, H. F., & Bullock, R. (1998). Relationship between excitatory amino acid release and outcome after severe human head injury. Acta Neurochirurgica. Supplement, 71, 244–246.
Kreisman, N. R., Hodin, R. A., Brizzee, B. L., Rosenthal, M., Sick, T. J., Busto, R., & Ginsberg, M. D. (1987). Seizure-associated pulmonary edema and cerebral oxygenation in the rat. Journal of Applied Physiology, 62, 658–667.
Lang, E. W., & Chesnut, R. M. (1995). Intracranial pressure and cerebral perfusion pressure in severe head injury. New Horizons, 3, 400–409.
Lauritzen, M. (1987). Cerebral blood flow in migraine and cortical spreading depression. Acta Neurologica Scandinavica. Supplementum, 113, 1–40.
Leão, A. A. P. (1944). Spreading depression of activity in cerebral cortex. Journal of Neurophysiology, 7, 359–390.
Leniger-Follert, E., Urbanics, R., Harbig, K., & Lubbers, D. W. (1977). The behavior of local pH and NADH-fluorescence during and after direct activation of the brain cortex. In D. H. Ingvar & N. A. Lassen (Eds.), Acta Neurologica Scandinavica (56th ed., pp. 214–215). Munkgaard.
Levy, J. V., & Richards, V. (1962). Effect of oxygen at high pressure (OHP) on asphyxial survival time of rats. Proceedings of the Society for Experimental Biology and Medicine, 109, 941–944.
Lewis, D. V., & Schuette, W. H. (1975). NADH fluorescence and [K+]o changes during hippocampal electrical stimulation. Journal of Neurophysiology, 38, 405–417.
Lewis, D. V., O’Connor, M. J., & Schuette, W. H. (1974). Oxidative metabolism during recurrent seizures in the penicillin treated hippocampus. Electroencephalography and Clinical Neurophysiology, 36, 347–356.
Lothman, E., LaManna, J., Cordingley, G., Rosenthal, M., & Somjen, G. (1975). Responses of electrical potential potassium levels, and oxidative metabolic activity of the cerebral neocortex of cats. Brain Research, 88, 15–36.
Manor, T., Rogatsky, G., Zarchin, N., & Mayevsky, A. (2003). Effects of fluid percussion injury on rat brain hemodynamics, ionic, electrical activity, and energy metabolism in vivo. Advances in Experimental Medicine and Biology, 510, 409–414.
Marmarou, A., Fatouros, P. P., Barzo, P., Portella, G., Yoshihara, M., Tsuji, O., Yamamoto, T., Laine, F., Signoretti, S., Ward, J. D., Bullock, M. R., & Young, H. F. (2000). Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients. Journal of Neurosurgery, 93, 183–193.
Marshall, W. H. (1959). Spreading cortical depression of Leão. Physiological Reviews, 39, 239–279.
Marshall, J. R., & Lambertsen, C. J. (1961). Interactions of increased pO2 and pCO2 effects in producing convulsions and death in mice. Journal of Applied Physiology, 16, 1–7.
Mayevsky, A. (1975). The effect of trimethadione on brain energy metabolism and EEG activity of the conscious rat exposed to HPO. Journal of Neuroscience Research, 1, 131–142.
Mayevsky, A. (1976). Brain energy metabolism of the conscious rat exposed to various physiological and pathological situations. Brain Research, 113, 327–338.
Mayevsky, A. (1978a). Ischemia in the brain: The effects of carotid artery ligation and decapitation on the energy state of the awake and anesthetized rat. Brain Research, 140, 217–230.
Mayevsky, A. (1978b). Pyridine nucleotide oxidation reduction state of the cerebral cortex in the awake gerbil. Journal of Neuroscience Research, 3, 369–374.
Mayevsky, A. (1978c). The responses of an awake brain to HPO under increased CO2 concentration. Advances in Experimental Medicine and Biology, 92, 735–740.
Mayevsky, A. (1978d). Shedding light on the awake brain. In P. L. Dutton, J. Leigh, & A. Scarpa (Eds.), Frontiers in bioenergetics: From electrons to tissues (2nd ed., pp. 1467–1476). Academic Press.
Mayevsky, A. (1983a). Metabolic, ionic and electrical responses to experimental epilepsy in the awake rat. In M. Baldy, D. H. Moulinier, D. H. Ingvar, & B. S. Meldrum (Eds.), Proceedings of the first international congress of cerebral blood flow, metabolism and epilepsy (pp. 263–270). John Libbey.
Mayevsky, A. (1983b). Multiparameter monitoring of the awake brain under hyperbaric oxygenation. Journal of Applied Physiology, 54, 740–748.
Mayevsky, A. (1984a). Brain NADH redox state monitored in vivo by fiber optic surface fluorometry. Brain Research Reviews, 7, 49–68.
Mayevsky, A. (1984b). Brain oxygen toxicity. Invited review. In A. J. Bachrach & M. M. Matzen (Eds.), Underwater physiology. 8th symposium (pp. 69–89). Undersea Medical Society Inc.
Mayevsky, A. (1992). Cerebral blood flow and brain mitochondrial redox state responses to various perturbations in gerbils. Advances in Experimental Medicine and Biology, 317, 707–716.
Mayevsky, A., & Chance, B. (1973). A new long-term method for the measurement of NADH fluorescence in intact rat brain with implanted cannula. Advances in Experimental Medicine and Biology, 37A, 239–244.
Mayevsky, A., & Chance, B. (1974). Repetitive patterns of metabolic changes during cortical spreading depression of the awake rat. Brain Research, 65, 529–533.
Mayevsky, A., & Chance, B. (1975). Metabolic responses of the awake cerebral cortex to anoxia hypoxia spreading depression and epileptiform activity. Brain Research, 98, 149–165.
Mayevsky, A., & Rogatsky, G. (2007). Mitochondrial function in vivo evaluated by NADH fluorescence: From animal models to human studies. American Journal of Physiology. Cell Physiology, 292, C615–C640.
Mayevsky, A., & Sclarsky, D. S. (1983). Correlation of brain NADH redox state, K+, PO2 and electrical activity during hypoxia, ischemia and spreading depression. Advances in Experimental Medicine and Biology, 159, 129–141.
Mayevsky, A., & Shaya, B. (1980). Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain. Journal of Applied Physiology, 49, 700–707.
Mayevsky, A., & Weiss, H. R. (1991). Cerebral blood flow and oxygen consumption in cortical spreading depression. Journal of Cerebral Blood Flow and Metabolism, 11, 829–836.
Mayevsky, A., Jamieson, D., & Chance, B. (1974a). Oxygen poisoning in the unanesthetized brain: Correlation of the oxidation-reduction state of pyridine nucleotide with electrical activity. Brain Research, 76, 481–491.
Mayevsky, A., Zeuthen, T., & Chance, B. (1974b). Measurements of extracellular potassium, ECoG and pyridine nucleotide levels during cortical spreading depression in rats. Brain Research, 76, 347–349.
Mayevsky, A., Crowe, W., & Mela, L. (1980b). The interrelation between brain oxidative metabolism and extracellular potassium in the unanesthetized gerbil. Neurological Research, 1, 213–226.
Mayevsky, A., Lebourdais, S., & Chance, B. (1980a). The interrelation between brain PO2 and NADH oxidation- reduction state in the gerbil. Journal of Neuroscience Research, 5, 173–182.
Mayevsky, A., Zarchin, N., & Friedli, C. M. (1982). Factors affecting the oxygen balance in the awake cerebral cortex exposed to spreading depression. Brain Research, 236, 93–105.
Mayevsky, A., Kaplan, H., Haveri, J., Haselgrove, J., & Chance, B. (1986b). Three-dimensional metabolic map** of the freeze-trapped brain: Effects of ischemia on the Mongolian gerbil. Brain Research, 367, 63–72.
Mayevsky, A., Zarchin, N., Yoles, E., & Tannenbaum, B. (1986a). Oxygen supply to the brain in hypoxic and hyperoxic conditions. In C. Nicolau (Ed.), Advances in the biosciences. “O2-transport in red blood cells” (pp. 119–132). Pergamon Press.
Mayevsky, A., Duckrow, R. B., Yoles, E., Zarchin, N., & Kanshansky, D. (1990a). Brain mitochondrial redox state, tissue hemodynamic and extracellular ion responses to four-vessel occlusion and spreading depression in the rat. Neurological Research, 12, 243–248.
Mayevsky, A., Frank, K. H., Nioka, S., Kessler, M., & Chance, B. (1990b). Oxygen supply and brain function in vivo: A multiparametric monitoring approach in the Mongolian gerbil. In J. Piper, T. K. Goldstick, & M. Meyer (Eds.), Oxygen transport to tissue XII (pp. 303–313). Plenum Pub.
Mayevsky, A., Flamm, E. S., Pennie, W., & Chance, B. (1991). A fiber optic based multiprobes system for intraoperative monitoring of brain functions. SPIE, 1431, 303–313.
Mayevsky, A., Zarchin, N., & Sonn, J. (1993). Brain redox state and O2 balance in experimental spreading depression and ischemia. In A. Lehmenkuhler, K.-H. Grotemeyer, & F. Tegtmeier (Eds.), Migraine - Basic Mechanisms and Treatment Urban & Schwarzenberg (pp. 379–393). Munchen-Wier.
Mayevsky, A., Meilin, S., Rogatsky, G. G., Zarchin, N., & Sonn, J. (1995). Multiparametric monitoring of the awake brain exposed to carbon monoxide. Journal of Applied Physiology, 78, 1188–1196.
Mayevsky, A., Doron, A., Manor, T., Meilin, S., Zarchin, N., & Ouaknine, G. E. (1996). Cortical spreading depression recorded from the human brain using a multiparametric monitoring system. Brain Research, 740, 268–274.
Mayevsky, A., Manor, T., Meilin, S., Doron, A., & Ouaknine, G. E. (1998). Real-time multiparametric monitoring of the injured human cerebral cortex – A new approach. In R. Marmarou & R. Bullock (Eds.), Acta neurochirurgica supplement (Wien.) (pp. 78–81). ICPX.
Mayevsky, A., Doron, A., Meilin, S., Manor, T., Ornstein, E., & Ouaknine, G. E. (1999b). Brain viability and function analyzer: Multiparametric real-time monitoring in neurosurgical patients. Acta Neurochirurgica. Supplementum (Wien), 75, 63–66.
Mayevsky, A., Meilin, S., Manor, T., Zarchin, N., & Sonn, J. (1999a). Optical monitoring of NADH redox state and blood flow as indicators of brain energy balance. Advances in Experimental Medicine and Biology, 471, 133–140.
McIntosh, T. K., Vink, R., Noble, L., Yamakami, I., Fernyak, S., Soares, H., & Faden, A. L. (1989). Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model. Neuroscience, 28, 233–244.
McIntosh, T. K., Juhler, M., & Wieloch, T. (1998). Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998. Journal of Neurotrauma, 15, 731–769.
Miller, J. D., Becker, D. P., Ward, J. D., Sullivan, H. G., Adams, W. E., & Rosner, M. J. (1977). Significance of intracranial hypertension in severe head injury. Journal of Neurosurgery, 47, 503–516.
Miller, J. D., Dearden, N. M., Piper, I. R., & Chan, K. H. (1992). Control of intracranial pressure in patients with severe head injury. Journal of Neurotrauma, 9(Suppl 1), S317–S326.
Moody, W. J., Futamachi, K. J., & Prince, D. A. (1974). Extracellular potassium activity during epileptogenesis. Experimental Neurology, 42, 248–263.
Mutch, W. A., & Hansen, A. J. (1984). Extracellular pH changes during spreading depression and cerebral ischemia: Mechanisms of brain pH regulation. Journal of Cerebral Blood Flow and Metabolism, 4, 17–27.
Nedergaard, M., & Hansen, A. J. (1993). Characterization of cortical depolarizations evoked in focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 13, 568–574.
Nilsson, P., Hillered, L., Ponten, U., & Ungerstedt, U. (1990). Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. Journal of Cerebral Blood Flow and Metabolism, 10, 631–637.
Nilsson, P., Hillered, L., Olsson, Y., Sheardown, M. J., & Hansen, A. J. (1993). Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats. Journal of Cerebral Blood Flow and Metabolism, 13, 183–192.
Nilsson, P., Gazelius, B., Carlson, H., & Hillered, L. (1996). Continuous measurement of changes in regional cerebral blood flow following cortical compression contusion trauma in the rat. Journal of Neurotrauma, 13, 201–207.
Norusis, M. J. (1999). Guide of data analysis. Prentice-Hall.
Obrist, W. D., Langfitt, T. W., Jaggi, J. L., Cruz, J., & Gennarelli, T. A. (1984). Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. Journal of Neurosurgery, 61, 241–253.
O’Connor, M. J., Herman, C. J., Rosenthal, M., & Jobsis, F. (1972). Intracellular redox changes preceding onset of epileptiform activity in intact cat hippocampus. Journal of Neurophysiology, 35, 471–483.
O’Connor, M. J., Lewis, D. V., & Herman, C. J. (1973). Effects of potassium on oxidative metabolism and seizures. Electroencephalography and Clinical Neurophysiology, 35, 205–208.
O’Connor, M. J., Welsh, F., Komarnicky, L., Davis, L., Stevens, J., Lewis, D., & Herman, C. (1977). Origin of labile NADH tissue fluorescence (pp. 90–99). Colloquium on Oxygen and Physiological Function. Professional Information Library, Dallas.
Ookawa, T., & Bures, J. (1975). Extracellular potassium shifts accompanying epileptic discharge induced in chicken hyperstriatum by systemic injection of Metrazol. Brain Research, 97, 171–176.
Otsuka, H., Ueda, K., Heimann, A., & Kempski, O. (2000). Effects of cortical spreading depression on cortical blood flow, impedance, DC potential, and infarct size in a rat venous infarct model. Experimental Neurology, 162, 201–214.
Ozawa, Y., Nakamura, T., Sunami, K., Kubota, M., Ito, C., Murai, H., Yamaura, A., & Makino, H. (1991). Study of regional cerebral blood flow in experimental head injury: Changes following cerebral contusion and during spreading depression. Neurologia Medico-Chirurgica (Tokyo), 31, 685–690.
Paton, W. D. (1967). Experiments on the convulsant and anaesthetic effects of oxygen. British Journal of Pharmacology and Chemotherapy, 29, 350–366.
Persson, L., & Hillered, L. (1992). Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis. Journal of Neurosurgery, 76, 72–80.
Pfenninger, J. (1984). Early prediction of outcome after severe head injury in children. Zeitschrift für Kinderchirurgie, 39, 223–228.
Piper, I. R., Miller, J. D., Dearden, N. M., Leggate, J. R., & Robertson, I. (1990). Systems analysis of cerebrovascular pressure transmission: An observational study in head-injured patients. Journal of Neurosurgery, 73, 871–880.
Puglia, C. D., Glauser, E. M., & Glauser, S. C. (1974). Core temperature response of rats during exposure to oxygen at high pressure. Journal of Applied Physiology, 36, 149–153.
Rogatsky, G. G., Mayevsky, A., Zarchin, N., & Doron, A. (1996). Continuous multiparametric monitoring of brain activities following fluid-percussion injury in rats: Preliminary results. Journal of Basic and Clinical Physiology and Pharmacology, 7, 23–43.
Rogatsky, G. G., Sonn, J., Kamenir, Y., Zarchin, N., & Mayevsky, A. (2003). Relationship between intracranial pressure and cortical spreading depression following fluid percussion brain injury in rats. Journal of Neurotrauma, 20, 1315–1325.
Rosenthal, M., & Jobsis, F. F. (1971). Intracellular redox changes in functioning cerebral cortex. II. Effects of direct cortical stimulation. Journal of Neuropsychology, 34, 750–762.
Rosenthal, M., & Somjen, G. (1973). Spreading depression, sustained potential shifts, and metabolic activity of cerebral cortex of cats. Journal of Neurophysiology, 36, 739–749.
Sanders, A. P., Hall, I. H., & Woodhall, B. (1965). Succinate: Protective agent against hyperbaric oxygen toxicity. Science, 150, 1830–1831.
Signoretti, S., Marmarou, A., Tavazzi, B., Lazzarino, G., Beaumont, A., & Vagnozzi, R. (2001). N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury. Journal of Neurotrauma, 18, 977–991.
Signorini, D. F., Andrews, P. J., Jones, P. A., Wardlaw, J. M., & Miller, J. D. (1999). Adding insult to injury: The prognostic value of early secondary insults for survival after traumatic brain injury. Journal of Neurology, Neurosurgery, and Psychiatry, 66, 26–31.
Somjen, G. G. (2001). Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiological Reviews, 81, 1065–1096.
Somjen, G. G., Rosenthal, M., Cordingley, G., LaManna, J., & Lothman, E. (1976). Potassium, neuroglia, and oxidative metabolism in central gray matter. Federation Proceedings, 35, 1266–1271.
Sonn, J., & Mayevsky, A. (2000). Effects of brain oxygenation on metabolic, hemodynamic, ionic and electrical responses to spreading depression in the rat. Brain Research, 882, 212–216.
Stein, S. N., & Sonnenschein, R. R. (1950). Electrical activity and oxygen tension of brain during hyperoxic convulsions. The Journal of Aviation Medicine, 21, 401–405.
Stocchetti, N., Barbagallo, M., Bellini, G. C., Furlan, A., Vezzani, A., & Nizzoli, V. (1991). Arterio-jugular difference of oxygen and intracranial pressure in comatose, head injured patients. II. Clinical correlations. Minerva Anestesiologica, 57, 327–334.
Strong, A. J., Fabricius, M., Boutelle, M. G., Hibbins, S. J., Hopwood, S. E., Jones, R., Parkin, M. C., & Lauritzen, M. (2002). Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke, 33, 2738–2743.
Sukoff, M. H., & Ragatz, R. E. (1982). Hyperbaric oxygenation for the treatment of acute cerebral edema. Neurosurgery, 10, 29–38.
Sukoff, M. H., Hollin, S. A., Espinosa, O. E., & Jacobson, J. H., 2nd. (1968). The protective effect of hyperbaric oxygenation in experimental cerebral edema. Journal of Neurosurgery, 29, 236–241.
Sullivan, H. G., Martinez, J., Becker, D. P., Miller, J. D., Griffith, R., & Wist, A. O. (1976). Fluid-percussion model of mechanical brain injury in the cat. Journal of Neurosurgery, 45, 521–534.
Sunami, K., Nakamura, T., Ozawa, Y., Kubota, M., Namba, H., & Yamaura, A. (1989). Hypermetabolic state following experimental head injury. Neurosurgical Review, 12(Suppl 1), 400–411.
Takano, K., Latour, L. L., Formato, J. E., Carano, R. A., Helmer, K. G., Hasegawa, Y., Sotak, C. H., & Fisher, M. (1996). The role of spreading depression in focal ischemia evaluated by diffusion map**. Annals of Neurology, 39, 308–318.
Taylor, H. J. (1949). The role of carbon dioxide in oxygen poisoning. The Journal of Physiology, 109, 272–280.
Tenny, R. T., Sharbrough, F. W., & Anderson, R. E. (1980). Correlation of intracellular redox states and pH with blood flow in primary and secondary seizure foci. Annals of Neurology, 8, 564–573.
Thomas, S., Tabibnia, F., Schuhmann, M. U., Brinker, T., & Samii, M. (2000). ICP and MABP following traumatic subarachnoid hemorrhage in the rat. Acta Neurochirurgica. Supplement, 76, 203–205.
Torbati, D., Parolla, D., & Lavy, S. (1977). Changes in local brain tissue PO2 and electrocortical activity of unanesthetized rabbits under high oxygen pressure. Aviation, Space, and Environmental Medicine, 48, 247–250.
Vern, B., Schuette, W. H., Whitehouse, W. C., & Mutsuga, N. (1976). Cortical oxygen consumption and NADH fluorescence during metrazole seizures in normotensive and hypotensive cats. Experimental Neurology, 52, 82–99.
Vyskocil, F., Kritz, N., & Bures, J. (1972). Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Research, 39, 255–259.
Wadhwani, K. C., Rapoport, S. I., Shepherd, A. P., & Oberg, P. A. (1990). Blood flow in the central and peripheral nervous systems. In P. A. Oberg (Ed.), Shephrd, a.P (pp. 265–304). Laser Doppler Blood Flowmetry Kluwer Academic Pub.
Wiebers, D. O., Adams, H. P., Jr., & Whisnant, J. P. (1990). Animal models of stroke: Are they relevant to human disease? Stroke, 21, 1–3.
Zauner, A., Daugherty, W. P., Bullock, M. R., & Warner, D. S. (2002). Brain oxygenation and energy metabolism: Part I-biological function and pathophysiology. Neurosurgery, 51, 289–301. discussion 302.
Zeuthen, T., Hiam, R. C., & Silver, I. A. (1974). Microelectrode recording of ion activity in brain. In H. J. Berman & N. C. Hebert (Eds.), Ion-selective microelectrodes. Advances in experimental medicine and biology (pp. 145–156). Springer.
Zeuthen, T., Dora, E., Silver, I. A., Chance, B., & Kovach, A. G. B. (1979). Mechanism of the cerebrocortical vasodilatation during anoxia. Acta Physiologica Academiae Scientiarum Hungaricae, 54, 305–318.
Zuckermann, E. C., & Glaser, G. H. (1968). Hippocampal epileptic activity induced by localized ventricular perfusion with high-potassium cerebrospinal fluid. Experimental Neurology, 20, 87–110.
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Mayevsky, A., Sonn, J. (2022). Spontaneous Development of CSD Related to Brain Pathophysiological Conditions. In: Cortical Spreading Depression of Leao. Springer, Cham. https://doi.org/10.1007/978-3-031-08068-5_5
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