Papaver somniferum L.

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Abstract

Papaver somniferum L., opium poppy, (Papaveraceae) has been used for several purposes since ancient times. P. somniferum L. is an annual herb that bears alkaloids such as morphine, codeine, noscapine, papaverine, etc., especially in its capsule. Thanks to these bioactive compounds, it has several therapeutic effects. Because of that, it has also been used against several illnesses for centuries. Until today, countless studies have been carried on P. somniferum L. and its bioactivities. These studies are focused on the isolation of bioactive alkaloids and synthesizing their various semi-synthetic and synthetic derivatives. Along with identification and bioactivity tests of alkaloids of opium poppy, their clinical behaviors were also examined by researchers from the whole world. Today, opium poppy, especially its alkaloids, became an indispensable part of medicine.

The objective of this chapter is to discuss Papaver somniferum L. with all aspects.

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References

  • Afzali M, Ghaeli P, Khanavi M, et al. Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells. DARU J Pharm Sci. 2015;23(16):1–8.

    Google Scholar 

  • Aggarwal M, Leser GP, Lamb RA. Repurposing papaverine as an antiviral agent against influenza viruses and paramyxoviruses. 2020. https://doi.org/10.1128/JVI.01888-19.

  • Akbar S. Handbook of 200 medicinal plants: a comprehensive review of their traditional medical uses and scientific justifications. Stockton: Springer; 2020.

    Book  Google Scholar 

  • Aksoylu Özbek Z, Günç Ergönül P. Determination of physicochemical properties, fatty acid, tocopherol, sterol and phenolic profiles of expeller–pressed poppy seed oils from Turkey. J Am Oil Chem Soc. 2020;97(6):591–602.

    Article  Google Scholar 

  • Albrecht T, Lee CH, Speelman DJ, Steinsland OS. Inhibition of cytomegalovirus replication by smooth-muscle relaxing agents. Proc Soc Exp Biol Med. 1987;186(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  • Alisaraie L, Tuszynski JA. Determination of noscapine’s localization and interaction with the tubulin-α/β heterodimer. Chem Biol Drug Des. 2011;78(4):535–46.

    Article  CAS  PubMed  Google Scholar 

  • Anderson EF. Ethnobotany of hill tribes of northern Thailand. II. Lahu medicinal plants. Econ Bot. 1986;40(4):442–50.

    Article  Google Scholar 

  • Baillif-Couniou V, Kintz P, Sastre C, et al. Hair testing in postmortem diagnosis of substance abuse: an unusual case of slow-release oral morphine abuse in an adolescent. J Forensic Leg Med. 2015;36(1):172–6.

    Article  PubMed  Google Scholar 

  • Balkrishna A, Misra L. Chemo-botanical and neurological accounts of some ayurvedic plants useful in mental health. Nat Prod J. 2018;8(1):14–31.

    CAS  Google Scholar 

  • Baser KH, Arslan N. Opium poppy (Papaver somniferum). In: Yaniv Z, Dudai N, editors. Medicinal and aromatic plants of the Middle-East. Dordrecht: Springer; 2015.

    Google Scholar 

  • Baytop T. Farmakognozi Ders Kitabı Cilt I. İstanbul Üniv Reman Basımevi Yay No: 339; 1986.

    Google Scholar 

  • Baytop T. A dictionary of vernacular names of wild plants of Turkey. 3rd ed. Ankara: The Turkish Language Society; 2007.

    Google Scholar 

  • Beltrán-Campos V, Silva-Vera M, García-Campos ML, Díaz-Cintra S. Efectos de la morfina en la plasticidad cerebral. Neurologia. 2015;30:176–80.

    Article  PubMed  Google Scholar 

  • Benítez G, González-Tejero MR, Molero-Mesa J. Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): Ethnopharmacological synthesis. J Ethnopharmacol. 2010;129(1):87–105.

    Article  PubMed  Google Scholar 

  • Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Physician. 2008;11(SPEC. ISS. 2):S105–20.

    Article  PubMed  Google Scholar 

  • Beyer J, Drummer OH, Maurer HCHH. Herbal drugs of abuse. In: Ramawat KG, editor. Herbal drugs: ethnomedicine to modern medicine. Berlin/Heidelberg: Springer; 2009. p. 353–67.

    Chapter  Google Scholar 

  • Bibi T, Ahmad M, Bakhsh Tareen R, et al. Ethnobotany of medicinal plants in district Mastung of Balochistan province-Pakistan. J Ethnopharmacol. 2014;157(1):79–89.

    Article  PubMed  Google Scholar 

  • Bishop-Freeman SC, Fox L, Winecker RE, Hudson JS. Death from poppy tea consumption. J Anal Toxicol. 2020;44(7):734–40.

    Article  CAS  PubMed  Google Scholar 

  • Bolser DC, Davenport PW. Codeine and cough: an ineffective gold standard. Curr Opin Allergy Clin Immunol. 2007;7:32–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Booth M. Opium: a history. London: Simon & Schuster; 1996.

    Google Scholar 

  • Brokjær A, Olesen AE, Kreilgaard M, et al. Objective markers of the analgesic response to morphine in experimental pain research. J Pharmacol Toxicol Methods. 2015;73:7–14.

    Article  PubMed  Google Scholar 

  • Bruneton J. Pharmacognosy, phytochemistry, medicinal plants. 2nd ed. Paris: Lavoisier; 1993.

    Google Scholar 

  • Bulut G, Haznedaroğlu MZ, Doğan A, et al. An ethnobotanical study of medicinal plants in Acipayam (Denizli-Turkey). J Herb Med. 2017;10(1):64–81.

    Article  Google Scholar 

  • Chaudhary SS, Aslam M, Siddiqui A. Tukhm khashkhaash (poppy seeds): a unani drug of multitudinous potential. J Drug Deliv Ther. 2019;9(2):528–33.

    Article  CAS  Google Scholar 

  • Chen X, Dang TTT, Facchini PJ. Noscapine comes of age. Phytochemistry. 2015;111(1):7–13.

    Article  CAS  PubMed  Google Scholar 

  • Chinnappan A. Ethnobotanical studies on useful plants of Sirumalai Hills of Eastern Ghats, Dindigul district of Tamilnadu, southern India. Int J Biosci. 2012;2(2):77–84.

    Google Scholar 

  • Dąbrowski G, Czaplicki S, Konopka I. Composition and quality of poppy (Papaver somniferum L.) seed oil depending on the extraction method. LWT. 2020;134:110167.

    Article  Google Scholar 

  • Dahlström B, Mellstrand T, Löfdahl CG, Johansson M. Pharmakokinetic properties of noscapine. Eur J Clin Pharmacol. 1982;22(6):535–9.

    Article  PubMed  Google Scholar 

  • Dart RC. Medical toxicology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2004.

    Google Scholar 

  • De Craen AJM, Di Giulio G, Lampe-Schoenmaeckers AJEM, et al. Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review. Br Med J. 1996;313(7053):321–5.

    Article  Google Scholar 

  • De Moraes MEA, Bezerra MM, Bezerra FAF, et al. Safety evaluation of Elixir paregorico® in healthy volunteers: a phase I study. Hum Exp Toxicol. 2008;27(10):751–6.

    Article  PubMed  Google Scholar 

  • Devereaux AL, Mercer SL, Cunningham CW. DARK classics in chemical neuroscience: morphine. ACS Chem Neurosci. 2018;9(10):2395–407.

    Article  CAS  PubMed  Google Scholar 

  • DrugBank Online. Noscapine: uses, interactions, mechanism of action. 2021a. https://go.drugbank.com/drugs/DB06174. Accessed 31 May 2021.

  • DrugBank Online. Codeine: uses, interactions, mechanism of action. 2021b. https://go.drugbank.com/drugs/DB00318. Accessed 31 May 2021.

  • DrugBank Online. Morphine: uses, interactions, mechanism of action. 2021c. https://go.drugbank.com/drugs/DB00295. Accessed 31 May 2021.

  • Eitan S, Emery MA, Bates MLS, Horrax C. Opioid addiction: who are your real friends? Neurosci Biobehav Rev. 2017;83:697–712.

    Article  PubMed  Google Scholar 

  • Ellinger B, Bojkova D, Zaliani A, et al. A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection. Sci Data. 2021;8(1):70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ertem H. Boğazköy metinleri göre Hititler devri Anadolu’sunun florası. Türk Tar Kurumu Yayınları. 1974;65(VII. Dizi — Sa. 65):77–181.

    Google Scholar 

  • Evans WC. Pharmacognosy. 16th ed. London: Elsevier; 2009.

    Google Scholar 

  • Fakir H, Korkmaz M, Güller B. Medicinal plant diversity of western Mediterrenean region in Turkey. J Appl Biol Sci. 2009;3(2):3–4.

    Google Scholar 

  • Friedrichsdorf SJ, Postier Nugent AC, Strobl AQ. Codeine-associated pediatric deaths despite using recommended dosing guidelines: three case reports. J Opioid Manag. 2013;9(2):151–5.

    Article  PubMed  Google Scholar 

  • Fu**aga M, Mazze RI. Teratogenic and postnatal developmental studies of morphine in Sprague-Dawley rats. Teratology. 1988;38(5):401–10.

    Article  CAS  PubMed  Google Scholar 

  • Fusi F, Manetti F, Durante M, et al. The vasodilator papaverine stimulates L-type Ca2+current in rat tail artery myocytes via a PKA-dependent mechanism. Vascul Pharmacol. 2016;76:53–61.

    Article  CAS  PubMed  Google Scholar 

  • Gaber A, Alsanie WF, Kumar DN, et al. Novel papaverine metal complexes with potential anticancer activities. Molecules. 2020;25(22):5477.

    Article  Google Scholar 

  • Ghaly PE, Abou El-Magd RM, Churchill CDM, et al. A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation. Oncotarget. 2016;7(26):40518–30.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gossel TA, Bricker JD. Principles of clinical toxicology. 3rd ed. London: CRC Press; 2001.

    Google Scholar 

  • Grant WM. Toxicology of the eye. 3rd ed. Springfield: Charles C. Thomas Publisher; 1986.

    Google Scholar 

  • Gras A, Serrasolses G, Vallès J, Garnatje T. Traditional knowledge in semi-rural close to industrial areas: ethnobotanical studies in western Gironès (Catalonia, Iberian Peninsula). J Ethnobiol Ethnomed. 2019;15(1):19.

    Article  PubMed  PubMed Central  Google Scholar 

  • Haber I, Pergolizzi J, LeQuang JA. Poppy seed tea: a short review and case study. Pain Ther. 2019;8(1):151–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hamilton GR, Baskett TF. In the arms of morpheus: the development of morphine for postoperative pain relief. Can J Anesth. 2000;47(4):367–74.

    Article  CAS  PubMed  Google Scholar 

  • Hao DC, Gu X-J, **ao PG. Phytochemical and biological research of Papaver pharmaceutical resources. In: Medicinal plants. London: Elsevier; 2015. p. 217–51.

    Chapter  Google Scholar 

  • Harris JD. Management of expected and unexpected opioid-related side effects. Clin J Pain. 2008;24:8–13.

    Article  Google Scholar 

  • Honda G, Yeşilada E, Tabata M, et al. Traditional medicine in Turkey VI. Folk medicine in West Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydin provinces. J Ethnopharmacol. 1996;53(2):75–87.

    CAS  PubMed  Google Scholar 

  • Hoskin PJ, Hanks GW. Morphine: pharmacokinetics and clinical practice. Br J Cancer. 1990;62:705–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hosztafi S. Chemical structures of alkaloids. In: Bernáth J, editor. Poppy: the genus Papaver. Amsterdam: Harwood Academic Publishers; 1998. p. 105–58.

    Google Scholar 

  • Inada M, Sato A, Shindo M, et al. Anticancer non-narcotic opium alkaloid papaverine suppresses human glioblastoma cell growth. Anticancer Res. 2019;39(12):6743–9.

    Article  CAS  PubMed  Google Scholar 

  • Jackson T, Chougule MB, Ichite N, et al. Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. Cancer Chemother Pharmacol. 2008;63:117–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jafarova Demirkapu M, Raci Yananli H. Opium Alkaloids. In: Bioactive compounds in nutraceutical and functional food for good human health. IntechOpen; 2021. p. 13.

    Google Scholar 

  • Kamei J. Role of opioidergic and serotonergic mechanisms in cough and antitussives. Pulm Pharmacol. 1996;9(5–6):349–56.

    Article  CAS  PubMed  Google Scholar 

  • Kang D, Qiang G-F, Du L-D, Du G-H. Papaverine. In: Natural small molecule drugs from plants. Singapore: Springer; 2018. p. 109–14.

    Chapter  Google Scholar 

  • Kapoor LD. Opium poppy: botany, chemistry and pharmacology. Boca Raton: CRC Press; 1995.

    Google Scholar 

  • Karlsson MO, Dahlström B, Eckernäs SÅ, et al. Pharmacokinetics of oral noscapine. Eur J Clin Pharmacol. 1990;39(3):275–9.

    Article  CAS  PubMed  Google Scholar 

  • Ke Y, Ye K, Grossniklaus HE, et al. Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. Cancer Immunol Immunother. 2000;49(4–5):217–25.

    Article  CAS  PubMed  Google Scholar 

  • Kesavan K, Ezell T, Bierman A, et al. Breathing and temperature control disrupted by morphine and stabilized by clonidine in neonatal rats. Respir Physiol Neurobiol. 2014;20:193–00.

    Google Scholar 

  • Klimas R, Mikus G. Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide. Br J Anaesth. 2014;113:935–44.

    Article  CAS  PubMed  Google Scholar 

  • Kujawska M, Klepacki P, Łuczaj Ł. Fischer’s plants in folk beliefs and customs: a previously unknown contribution to the ethnobotany of the Polish-Lithuanian-Belarusian borderland. J Ethnobiol Ethnomed. 2017;13(1):1–15.

    Article  Google Scholar 

  • Kültür Ş. Medicinal plants used in Kırklareli Province (Turkey). J Ethnopharmacol. 2007;111(2):341–64.

    Article  PubMed  Google Scholar 

  • Landen JW, Lang R, McMahon SJ, et al. Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 2002;62(14):4109–14.

    CAS  PubMed  Google Scholar 

  • Landen JW, Hau V, Wang M, et al. Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth. Clin Cancer Res. 2004;10(15):5187–201.

    Article  CAS  PubMed  Google Scholar 

  • Lee S, **ao C, Pei S. Ethnobotanical survey of medicinal plants at periodic markets of Honghe Prefecture in Yunnan Province, SW China. J Ethnopharmacol. 2008;117(2):362–77.

    Article  PubMed  Google Scholar 

  • Li C, Li L, Qin Y, et al. Exogenous morphine inhibits the growth of human gastric tumor in vivo. Ann Transl Med. 2020;8(6):385.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lim TK. Edible medicinal and non-medicinal plants. London: Springer; 2016.

    Book  Google Scholar 

  • Liu HM, Tu YK. The efficacy of papaverine administration by different routes for the treatment of experimental acute cerebral vasospasm. J Clin Neurosci. 2002;9(5):561–5.

    Article  CAS  PubMed  Google Scholar 

  • Liu QZ, Shao Y, Shang XJ, Li WY. Impact of morphine on the reproductivity of male rats. Zhonghua Nan Ke Xue. 2014;20(12):1073–6.

    CAS  PubMed  Google Scholar 

  • Lockie A. Encyclopedia of homeopathy. 2nd ed. London: Dorling Kindersley; 2006.

    Google Scholar 

  • Lötsch J. Pharmacokinetic-pharmacodynamic modeling of opioids. J Pain Symptom Manage. 2005;29. Elsevier Inc.:90–103.

    Article  Google Scholar 

  • Lötsch J, Dudziak R, Freynhagen R, et al. Fatal respiratory depression after multiple intravenous morphine injections. Clin Pharmacokinet. 2006;45:1051–60.

    Article  PubMed  Google Scholar 

  • Mahmoudian M, Rahimi-Moghaddam P. The anti-cancer activity of noscapine: a review. Recent Pat Anticancer Drug Discov. 2008;4(1):92–7.

    Article  Google Scholar 

  • Mani D, Dhawan SS. Scientific basis of therapeutic uses of opium poppy (Papaver somniferum) in ayurveda. Acta Hortic. 2014;1036(1036):175–80.

    Article  Google Scholar 

  • Martínez MA, Ballesteros S. Opium poisoning in modern times. An overview. Forensic Sci Int. 2019;302:109848.

    Article  PubMed  Google Scholar 

  • Masihuddin M, Jafri M, Siddiqui A, Chaudhary S. Traditional uses, phytochemistry and pharmacological activities of Papaver somniferum with special reference of unani medicine and updated review. J Drug Deliv Ther. 2018;8(5-s):110–4.

    Article  CAS  Google Scholar 

  • Mat A. Osmanlı İmparatorluğu’nda afyonun tarihi. Stud Ottoman Sci. 2010a;11(1):285–90.

    Google Scholar 

  • Mat A. Bitkiden İlaca: Hepsinin Bir Öyküsü Var. Istanbul: Pharmavision; 2010b.

    Google Scholar 

  • Maurya N, Kumar Maurya J, Singh UK, et al. In vitro cytotoxicity and interaction of noscapine with human serum albumin: effect on structure and esterase activity of HSA. 2019. https://doi.org/10.1021/acs.molpharmaceut.8b00864.

  • Miller CA, Carrigant DR. Reversible repression and activation of measles virus infection in neural cells (paramyxovirus/persistent infection/membrane protein/cyclic nucleotide). Proc Natl Acad Sci U S A. 1982;79:1629–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mir MA, Hamdani SS, Sheikh BA, Mehraj U. Recent advances in metabolites from medicinal plants in cancer prevention and treatment. Curr Immunol Rev. 2019;15(2):185–201.

    Article  CAS  Google Scholar 

  • Monteil-Ganiere C, Gaulier JM, Chopineaux D, et al. Fatal anoxia due to rachacha consumption: two cases reported. Forensic Sci Int. 2014;245:e1–5.

    Article  PubMed  Google Scholar 

  • Musa Özcan M, Atalay Ç. Determination of seed and oil properties of some poppy (Papaver somniferum L.) varieties. Grasas y Aceites. 2006;57(2):169–74.

    Article  Google Scholar 

  • Muthukumaran P, Kumaravel S, Nimia N. Phytochemical, GC-MS and FT-IR analysis of Papaver somniferum L. J Pharm Biol Sci. 2019;7(1):1–8.

    Article  Google Scholar 

  • Newcomb EW, Lukyanov Y, Schnee T, et al. Noscapine inhibits hypoxia-mediated HIF-1α expression and angiogenesis in vitro: a novel function for an old drug. Int J Oncol. 2006;28(5):1121–30.

    CAS  PubMed  Google Scholar 

  • Newcomb EW, Lukyanov Y, Smirnova I, et al. Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway. Anticancer Drugs. 2008;19(6):553–63.

    Article  CAS  PubMed  Google Scholar 

  • Nokta M, Albrecht T, Pollard R. Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function. Immunopharmacology. 1993;26(2):181–5.

    Article  CAS  PubMed  Google Scholar 

  • Noureini SK, Wink M. Antiproliferative effect of the isoquinoline alkaloid papaverine in hepatocarcinoma HepG-2 cells - inhibition of telomerase and induction of senescence. Molecules. 2014;19(8):11846–59.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ozturk M, Altay V, Latiff A, et al. A comparative analysis of the medicinal plants used for diabetes mellitus in the traditional medicine in Turkey, Pakistan, and Malaysia. In: Plant and human health, volume 1. Cham: Springer International Publishing; 2018a. p. 409–61.

    Chapter  Google Scholar 

  • Ozturk M, Altay V, Latiff A, et al. Potential medicinal plants used in the hypertension in Turkey, Pakistan, and Malaysia. In: Plant and human health, volume 1. Cham: Springer International Publishing; 2018b. p. 595–618.

    Chapter  Google Scholar 

  • Pacifici GM. Metabolism and pharmacokinetics of morphine in neonates: a review. Clinics. 2016;71:474–80.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pandey A, Jena SN, Shukla S. Impact of abiotic stresses on metabolic adaptation in opium poppy (Papaver somniferum L.). In: Metabolic adaptations in plants during abiotic stress. Boca Raton: CRC Press; 2019. p. 369–79.

    Google Scholar 

  • Porst H, Burnett A, Brock G, et al. SOP conservative (medical and mechanical) treatment of erectile dysfunction. J Sex Med. 2013;10(1):130–71.

    Article  CAS  PubMed  Google Scholar 

  • Pratt VM, Scott SA, Pirmohamed M, et al. Codeine therapy and CYP2D6 genotype. In: Medical genetics summaries [Internet]. Bethesda: National Center for Biotechnology Information (US); 2012.

    Google Scholar 

  • Presley CC, Lindsley CW. DARK classics in chemical neuroscience: opium, a historical perspective. ACS Chem Neurosci. 2018;9(10):2503–18.

    Article  CAS  PubMed  Google Scholar 

  • Pushpangadan P, Singh SP. Poppy. In: Peter KV, editor. Handbook of herbs and spices. Boca Raton: CRC Press; 2000. p. 261–8.

    Google Scholar 

  • Pushpangadan P, George V, Singh SP. Poppy. In: Peter KV, editor. Handbook of herbs and spices. 2nd ed. Cambridge: Elsevier; 2012. p. 437–48.

    Chapter  Google Scholar 

  • Rahimi A, Arslan N, Afshar K, et al. Variation in fatty acid composition of four Turkish registered poppy (Papaver somniferum L.) seeds in two locations (Ankara and Boldavin) of Turkey. Eur Online J Nat Soc Sci. 2015;4(1):183–90.

    Google Scholar 

  • Rao RR, Jamir NS. Ethnobotanical studies in Nagaland. I. Medicinal plants. Econ Bot. 1982;36(2):176–81.

    Article  Google Scholar 

  • Reynolds SM, Mackenzie AJ, Spina D, Page CP. The pharmacology of cough. Trends Pharmacol Sci. 2004;25(11):569–76.

    Article  CAS  PubMed  Google Scholar 

  • Rida PCG, Livecche D, Ogden A, et al. The noscapine chronicle: a pharmaco-historic b biography of the opiate alkaloid family and its clinical applications. Med Res Rev. 2015;35(5):1072–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ruiz-Garcia V, Lopez-Briz E. Morphine remains gold standard in breakthrough cancer pain. BMJ. 2008;337(dec24 1):a3104.

    Article  PubMed  Google Scholar 

  • Sajadian S, Vatankhah M, Majdzadeh M, et al. Toxicology mechanisms and methods cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells. Toxicol Mech Methods. 2015;25(5):388–95.

    Article  CAS  PubMed  Google Scholar 

  • Salsitz EA. Chronic pain, chronic opioid addiction: a complex nexus. J Med Toxicol. 2016;12(1):54–7.

    Article  CAS  PubMed  Google Scholar 

  • Sandberg F, Corrigan D. Natural remedies: their origins and uses. London: Taylor & Francis; 2001.

    Book  Google Scholar 

  • Savić J, Mačukanović-Jocić M, Jarić S. Medical ethnobotany on the Javor Mountain (Bosnia and Herzegovina). Eur J Integr Med. 2019;27:52–64.

    Article  Google Scholar 

  • Savithramma N, Sulochana C, Rao KN. Ethnobotanical survey of plants used to treat asthma in Andhra Pradesh, India. J Ethnopharmacol. 2007;113(1):54–61.

    Article  CAS  PubMed  Google Scholar 

  • Schiff PL. Opium and its alkaloids. Am J Pharm Educ. 2002;66(2):186–94.

    Google Scholar 

  • Sezik E, Yesilada E, Shadidoyatov H, et al. Folk medicine in Uzbekistan: I. Toshkent, Djizzax, and Samarqand provinces. J Ethnopharmacol. 2004;92(2–3):197–207.

    Article  PubMed  Google Scholar 

  • Shen L, Niu J, Wang C, et al. High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses. J Virol. 2019;93(12):e00023-19.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shepard TH. Catalog of teratogenic agents. 13th ed. Baltimore: The Johns Hopkins University Press; 2010.

    Google Scholar 

  • Steinhorn R, McPherson C, Anderson PJ, et al. Neonatal morphine exposure in very preterm infants—cerebral development and outcomes. J Pediatr. 2015;166(5):1200–7.e4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sueoka E, Sueoka N, Kai Y, et al. Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-κB activation. Biochem Biophys Res Commun. 1998;252(3):566–70.

    Article  CAS  PubMed  Google Scholar 

  • Sverrisdóttir E, Lund TM, Olesen AE, et al. A review of morphine and morphine-6-glucuronide’s pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain. Eur J Pharm Sci. 2015;74:45–62.

    Article  PubMed  Google Scholar 

  • Tang X, Chen Y, Ran H, et al. Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice. Biol Reprod. 2015;92(5):1–9.

    Article  CAS  Google Scholar 

  • Turano A, Scura G, Caruso A, et al. Inhibitory effect of papaverine on HIV replication in vitro. AIDS Res Hum Retrovir. 1989;5(2):183–92.

    Article  CAS  PubMed  Google Scholar 

  • Tuttolomondo T, Licata M, Leto C, et al. Ethnobotanical investigation on wild medicinal plants in the Monti Sicani Regional Park (Sicily, Italy). J Ethnopharmacol. 2014;153(3):568–86.

    Article  PubMed  Google Scholar 

  • Untoro J, Schultink W, West CE, et al. Efficacy of oral iodized peanut oil is greater than that of iodized poppy seed oil among Indonesian schoolchildren. Am J Clin Nutr. 2006;84(5):1208–14.

    Article  CAS  PubMed  Google Scholar 

  • Valiakos E, Marselos M, Sakellaridis N, et al. Ethnopharmacological approach to the herbal medicines of the “Antidotes” in Nikolaos Myrepsos′ Dynameron. J Ethnopharmacol. 2015;163:68–82.

    Article  CAS  PubMed  Google Scholar 

  • Van Thuyne W, Van Eenoo P, Delbeke FT. Urinary concentrations of morphine after the administration of herbal teas containing Papaveris fructus in relation to do** analysis. J Chromatogr B Anal Technol Biomed Life Sci. 2003;785(2):245–51.

    Article  Google Scholar 

  • van Wyk BE, Wink M. Medicinal plants of the world: an illustrated scientific guide to important medicinal plants and their uses. Portland: Timber Press; 2004.

    Google Scholar 

  • Wang S. Historical review: opiate addiction and opioid receptors. Cell Transplant. 2019;28(3):233–8.

    Article  PubMed  Google Scholar 

  • Xu G, Niu Z, Dong J, et al. Noscapine inhibits human hepatocellular carcinoma growth through inducing apoptosis in vitro and in vivo. Neoplasma. 2016;63(5):726–33.

    Article  CAS  PubMed  Google Scholar 

  • Yang ZR, Liu M, Peng XL, et al. Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro. Biochem Biophys Res Commun. 2012;421(3):627–33.

    Article  CAS  PubMed  Google Scholar 

  • Yazici L, Yilmaz G. Investigation of alkaloids in opium poppy (Papaver somniferum l.) varieties and hybrids. J Agr Sci-Tarim Bili. 2021;27(1):62–8.

    Google Scholar 

  • Yeşilada E, Sezik E, Honda G, et al. Traditional medicine in Turkey IX: folk medicine in north-west Anatolia. J Ethnopharmacol. 1999;64(3):195–210.

    Article  PubMed  Google Scholar 

  • Yoshikawa Y, Yamanouchi K. Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells. J Virol. 1984;50(2):489–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Young LY, Koda-Kimble MA, Kradjan WA, Guglielmo BJ. Applied therapeutics: the clinical use of drugs. 6th ed. Vancouver: Applied Therapeutics; 1995.

    Google Scholar 

  • Zhou J, Panda D, Landen JW, et al. Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint. J Biol Chem. 2002;277(19):17200–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Ömerül Faruk Tavlı .

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Tavlı, Ö.F. (2022). Papaver somniferum L.. In: Gürağaç Dereli, F.T., Ilhan, M., Belwal, T. (eds) Novel Drug Targets With Traditional Herbal Medicines. Springer, Cham. https://doi.org/10.1007/978-3-031-07753-1_31

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