Abstract
Herbal and traditional medicines (HTMs) are widely used throughout the world; however, HTM-related adverse reactions, including HTM-induced liver injury, have not been fully investigated. This chapter reviewed the current status and epidemiology of HTM-induced liver injury around the world, which revealed divergent data from different countries. Not surprisingly, the most implicated species of HTM-induced liver injury are remarkably distinct between Western countries and Eastern countries, namely China; this warrants specific considerations in pharmacovigilance for HTM-induced liver injury in different areas. The main risk factors and mechanisms for HTM-induced liver injury are also summarized and discussed using Polygonum multiflorum (heshouwu; accepted name: Reynoutria multiflora (Thunb.) Moldenke) as an example.
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Wang, Jb., Gao, Y., Guo, Ym., **ao, Xh. (2022). Pharmacovigilance for Herbal and Traditional Medicine-Induced Liver Injury. In: Barnes, J. (eds) Pharmacovigilance for Herbal and Traditional Medicines. Adis, Cham. https://doi.org/10.1007/978-3-031-07275-8_4
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