Abstract
Ageing process is a crucial phenomenon of life that deals with the proceedings of deadly and unmodified changes by impairment of biomolecules (Proteins, Lipids, and DNA), cells, tissues, and organs. It is an inescapable event but it could be delayed via both genetic and dietary interventions. The proper use of natural compounds along with regulation of diet can be beneficial in overcoming premature death and age-related diseases. Natural compounds have been known to suppress the stress responsive pathways and induce the longevity pathways (DNA damage repair pathway). Phytochemicals represent high anti-ageing potential and other health-promoting properties. Among all plants/cereals, minor cereals like millets are a rich source of calcium, iron, methionine, high fibre, polyphenols, and secondary metabolites which exhibit various health-beneficial properties including anti-ageing potential. In this book chapter, prima facie we will address the role of phytochemicals that are found in millets. The main emphasis will be on finger millet and we will summarize the critical reports that are relevant to the significant health benefits along with anti-ageing properties of phytochemicals from finger millet. Further, we will also discuss the underlying mechanisms of deferment of ageing and age-related diseases by phytochemicals of millets via affecting the processes like genetic repair, protein glycation, and stress responsive pathways. Furthermore, we will shed light on the well-established phytochemicals for their significant use in anti-ageing drugs. In conclusion, we suggest and promote awareness about the development of novel formulations/combinations based on millets to utilize their anti-ageing potential for human welfare.
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Kumar, A., Rani, M., Kumari, R., Shah, P., Mani, S., Sood, S. (2022). Novel Prospective on Suppression of Ageing by the Consumption of Finger Millet. In: Kumar, A., Sood, S., Babu, B.K., Gupta, S.M., Rao, B.D. (eds) The Finger Millet Genome. Compendium of Plant Genomes. Springer, Cham. https://doi.org/10.1007/978-3-031-00868-9_15
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