Abstract
Alcohol consumption is associated with roughly 50% of violent crimes. Despite the pervasiveness of this phenomenon, there is little understood about the neurobiological mechanisms underlying alcohol-induced aggression. This gap in our understanding arises due to the complex interaction of alcohol with the nervous system as well as ethical constraints that restrict the types of behavioral paradigms that can be used to investigate human alcohol-induced violence. Using animal models is an attractive solution to bridge this gap in knowledge, as researchers can leverage extensive genetic toolkits to precisely manipulate genes and neurons to functionally validate correlates and dynamically model alcohol-induced aggression due to more relaxed ethical constraints compared to human research. Ultimately, identifying correlates that control alcohol-induced aggression will allow for development of drug therapies that effectively reduce violent tendencies while under the influence of alcohol. This chapter highlights the studies using Mus musculus and Drosophila melanogaster that have identified molecular correlates regulating alcohol-induced aggression.
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Abbreviations
- 5-HIAA:
-
5-Hydroxyindoleacetic acid
- 5HT:
-
5-Hydroxytryptamine
- ADH:
-
Alcohol dehydrogenase
- AHA:
-
Alcohol-heightened aggressor
- ANA:
-
Alcohol non-heightened aggressor
- CRF:
-
Corticotrophin-releasing factor
- cVa:
-
11-cis Vaccenyl acetate
- D2 receptor:
-
Dopamine D2-like receptor
- DRN:
-
Dorsal raphe nucleus
- Esr1:
-
Estrogen receptor 1
- FruM:
-
Male variant of fruitless
- GABA:
-
γ-Aminobutyric acid
- GRABDA:
-
G-protein-coupled receptor-activation-based DA sensor
- ILmPFC:
-
Infralimbic medial prefrontal cortex
- GIRK:
-
G-protein-coupled inward rectifying potassium channel
- LGIC:
-
Ligand-gated ion channels
- LHb:
-
Lateral habenula
- lPAG:
-
Lateral periaqueductal gray
- mGluR:
-
Metabotropic glutamate receptor
- mPFC:
-
Medial prefrontal cortex
- NMDAR:
-
N-methyl-D-aspartate receptor
- NPF:
-
Neuropeptide F
- PLmPFC:
-
Prelimbic medial prefrontal cortex
- PV:
-
Parvalbumin
- RGS2:
-
Regulator of G-protein signaling 2
- SNMP:
-
Sensory neuron membrane protein
- SNP:
-
Single nucleotide polymorphisms
- T1 sensilla:
-
Trichoid 1 sensilla
- Tk:
-
Tachykinin
- VMHvl:
-
Ventrolateral subdivision of the ventromedial hypothalamus
- VTA:
-
Ventral tegmental area
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Park, A. (2023). Neurobiology of Alcohol-Induced Aggression. In: Martin, C., Preedy, V.R., Patel, V.B. (eds) Handbook of Anger, Aggression, and Violence. Springer, Cham. https://doi.org/10.1007/978-3-030-98711-4_88-1
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