Abstract
Left ventricular hypertrophy (LVH) in aortic stenosis (AS) is known as an adaptive response affected by pressure overload as a result of the progressive narrowing of the aortic valve orifice. Both systolic and diastolic function of the left ventricular (LV) could be affected due to the structural remodelling as a sequel of AS. Therefore, this study utilized 3D+ time personalized LV modelling algorithm which was developed in-house to evaluate the LV function throughout the 20 cardiac phases of short- and long-axis cine MRI in different severity of AS patients. A total of 9 healthy cohorts and 13 AS patients with different degrees of severity were analyzed. This study demonstrated that majority of the AS patients have systolic dysfunction accompanied by deterioration of radial strain (RS) and longitudinal strain (LS) when compared against healthy cohorts (p < 0.05). Only those with concomitant concentric LVH (i.e. 38% of the AS patients) exhibited normal systolic and diastolic functions with a couple of exceptions observed. LVH was found developed in those with moderate and severe AS. No clear correlation was found between diastolic dysfunction and the severity of AS.
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This study was supported by Universiti Malaya Faculty Research Grant (GPF053B-2020).
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Chuah, S.H., Thong, W.D., Sari, N.A.M., Tan, L.K., Hasikin, K., Liew, Y.M. (2022). Assessment of LV Myocardial Function in Aortic Stenosis Using Personalized 3D+ Time Cardiac MRI Modelling. In: Usman, J., Liew, Y.M., Ahmad, M.Y., Ibrahim, F. (eds) 6th Kuala Lumpur International Conference on Biomedical Engineering 2021. BIOMED 2021. IFMBE Proceedings, vol 86 . Springer, Cham. https://doi.org/10.1007/978-3-030-90724-2_46
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DOI: https://doi.org/10.1007/978-3-030-90724-2_46
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