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Diagnosis and Management of Thyroiditis: Hashimoto, de Quervain, Riedel

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Endocrine Surgery Comprehensive Board Exam Guide

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Abstract

The content of this chapter includes an introduction to three thyroiditis syndromes – Hashimoto, de Quervain, and Riedel. The clinical presentation and diagnostic features of each are discussed in detail. Medical management for each condition is reviewed. Surgical indications for each type of thyroiditis are discussed, with a focus on clinical outcomes. While surgery is not often indicated for thyroiditis alone, surgical treatment of coexistent thyroid nodules or malignancy is often warranted. The impact of inflammatory thyroid conditions on the diagnostic evaluation of nodules and malignancy is reviewed. This chapter begins with a case example and a series of multiple-choice questions and answers to strengthen the reader’s understanding.

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References

  1. Noureldine S, Tufano R. Association of Hashimoto’s thyroiditis and thyroid cancer. Curr Opin Oncol. 2015;27(1):21–5.

    Article  PubMed  Google Scholar 

  2. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003;348(26):2646–55.

    Article  PubMed  Google Scholar 

  3. McLeod DSA, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012;42(2):252–65.

    Article  CAS  PubMed  Google Scholar 

  4. Vanderpump MPJ. The epidemiology of thyroid disease. Br Med Bull. 2011;99(1):39–51.

    Article  PubMed  Google Scholar 

  5. Ragusa F, Fallahi P, Elia G, Gonnella D, Paparo SR, Giusti C, et al. Hashimotos’ thyroiditis: epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab. 2019;33(6):101367.

    Article  PubMed  Google Scholar 

  6. Hu S, Rayman MP. Multiple nutritional factors and the risk of Hashimoto’s thyroiditis. Thyroid. 2017;27(5):597–610.

    Article  CAS  PubMed  Google Scholar 

  7. Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid. 2016;26(12):1681–92.

    Article  CAS  PubMed  Google Scholar 

  8. Belin RM, Astor BC, Powe NR, Ladenson PW. Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the Third National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2004;89(12):6077–86.

    Article  CAS  PubMed  Google Scholar 

  9. Effraimidis G, Tijssen JGP, Wiersinga WM. Discontinuation of smoking increases the risk for develo** thyroid peroxidase antibodies and/or thyroglobulin antibodies: a prospective study. J Clin Endocrinol Metab. 2009;94(4):1324–8.

    Article  CAS  PubMed  Google Scholar 

  10. Takami HE, Miyabe R, Kameyama K. Hashimoto’s thyroiditis. World J Surg. 2008;32(5):688–92.

    Article  PubMed  Google Scholar 

  11. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4):391–7.

    Article  CAS  PubMed  Google Scholar 

  12. Caleo A, Vigliar E, Vitale M, Di Crescenzo V, Cinelli M, Carlomagno C, et al. Cytological diagnosis of thyroid nodules in Hashimoto thyroiditis in elderly patients. BMC Surg. 2013;13(Suppl 2):S41.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Singer PA. Thyroiditis. Acute, subacute, and chronic. Med Clin North Am. 1991;75(1):61–77.

    Article  CAS  PubMed  Google Scholar 

  14. Nabhan ZM, Kreher NC, Eugster EA. Hashitoxicosis in children: clinical features and natural history. J Pediatr. 2005;146(4):533–6.

    Article  PubMed  Google Scholar 

  15. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008;29(1):76–131.

    Article  CAS  PubMed  Google Scholar 

  16. Orloff LA. Head and neck ultrasonography: essential and extended applications. 2nd: Plural Publishing; 2017. 545 p.

    Google Scholar 

  17. Kangelaris GT, Kim TB, Orloff LA. Role of ultrasound in thyroid disorders. Otolaryngol Clin N Am. 2010;43(6):1209–27.

    Article  Google Scholar 

  18. Li Y, Zhou G, Ozaki T, Nishihara E, Matsuzuka F, Bai Y, et al. Distinct histopathological features of Hashimoto’s thyroiditis with respect to IgG4-related disease. Mod Pathol. 2012;25(8):1086–97.

    Article  PubMed  Google Scholar 

  19. Samuels MH. Subacute, silent, and postpartum thyroiditis. Med Clin North Am. 2012;96(2):223–33.

    Article  CAS  PubMed  Google Scholar 

  20. Bindra A, Braunstein GD. Thyroiditis. Am Fam Physician. 2006;73(10):1769–76.

    PubMed  Google Scholar 

  21. Iyer PC, Cabanillas ME, Waguespack SG, Hu MI, Thosani S, Lavis VR, et al. Immune-related thyroiditis with immune checkpoint inhibitors. Thyroid. 2018;28(10):1243–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Neppl C, Kaderli RM, Trepp R, Schmitt AM, Berger MD, Wehrli M, et al. Histology of nivolumab-induced thyroiditis. Thyroid. 2018;28(12):1727–8.

    Article  PubMed  Google Scholar 

  23. Benbassat CA, Olchovsky D, Tsvetov G, Shimon I. Subacute thyroiditis: clinical characteristics and treatment outcome in fifty-six consecutive patients diagnosed between 1999 and 2005. J Endocrinol Investig. 2007;30(8):631–5.

    Article  CAS  Google Scholar 

  24. Fatourechi V, Aniszewski JP, Fatourechi GZE, Atkinson EJ, Jacobsen SJ. Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study. J Clin Endocrinol Metab. 2003;88(5):2100–5.

    Article  CAS  PubMed  Google Scholar 

  25. Lio S, Pontecorvi A, Caruso M, Monaco F, D’Armiento M. Transitory subclinical and permanent hypothyroidism in the course of subacute thyroiditis (de Quervain). Acta Endocrinol. 1984;106(1):67–70.

    CAS  Google Scholar 

  26. Kitchener MI, Chapman IM. Subacute thyroiditis: a review of 105 cases. Clin Nucl Med. 1989;14(6):439–42.

    Article  CAS  PubMed  Google Scholar 

  27. Randolph GW, editor. Surgery of the thyroid and parathyroid glands. 3rd ed. Philadelphia: Elsevier Health Sciences; 2020. 1010 p.

    Google Scholar 

  28. Frates MC, Marqusee E, Benson CB, Alexander EK. Subacute granulomatous (de Quervain) thyroiditis: grayscale and color Doppler sonographic characteristics. J Ultrasound Med. 2013;32(3):505–11.

    Article  PubMed  Google Scholar 

  29. Ranganath R, Shaha MA, Xu B, Migliacci J, Ghossein R, Shaha AR. de Quervain’s thyroiditis: a review of experience with surgery. Am J Otolaryngol. 2016;37(6):534–7.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Hay ID. Thyroiditis: a clinical update. Mayo Clin Proc. 1985;60(12):836–43.

    Article  CAS  PubMed  Google Scholar 

  31. Levy JM, Hasney CP, Friedlander PL, Kandil E, Occhipinti EA, Kahn MJ. Combined mycophenolate mofetil and prednisone therapy in tamoxifen- and prednisone-resistant Reidel’s thyroiditis. Thyroid. 2010;20(1):105–7.

    Article  CAS  PubMed  Google Scholar 

  32. Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V. Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976–2008. Thyroid. 2011;21(7):765–72.

    Article  PubMed  Google Scholar 

  33. Baloch ZW, Saberi M, Livolsi VA. Simultaneous involvement of thyroid by Riedel’s [correction of Reidel’s] disease and fibrosing Hashimoto’s thyroiditis: a case report. Thyroid. 1998;8(4):337–41.

    Article  CAS  PubMed  Google Scholar 

  34. Khan MAB, Hashmi SMH, Prinsley PR, Premachandra DJ. Reidel’s thyroiditis and Tolosa-Hunt syndrome, a rare association. J Laryngol Otol. 2004;118(2):159–61.

    Article  CAS  PubMed  Google Scholar 

  35. Dahlgren M, Khosroshahi A, Nielsen GP, Deshpande V, Stone JH. Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res. 2010;62(9):1312–8.

    Article  Google Scholar 

  36. Watanabe T, Maruyama M, Ito T, Fu**aga Y, Ozaki Y, Maruyama M, et al. Clinical features of a new disease concept, IgG4-related thyroiditis. Scand J Rheumatol. 2013;42(4):325–30.

    Article  CAS  PubMed  Google Scholar 

  37. Falhammar H, Juhlin CC, Barner C, Catrina S-B, Karefylakis C, Calissendorff J. Riedel’s thyroiditis: clinical presentation, treatment and outcomes. Endocrine. 2018;60(1):185–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Kumar N, Gupta R, Sayed S, Moloo Z, Vinayak S, Ahmed M. Difficulties in diagnosis of Riedel’s thyroiditis on aspiration cytology: a case report and brief review of the literature. Diagn Cytopathol. 2019;47(5):512–6.

    Article  PubMed  Google Scholar 

  39. Li Y, Nishihara E, Kakudo K. Hashimoto’s thyroiditis: old concepts and new insights. Curr Opin Rheumatol. 2011;23(1):102–7.

    Article  PubMed  Google Scholar 

  40. Yasmeen T, Khan S, Patel SG, Reeves WA, Gonsch FA, de Bustros A, et al. Clinical case seminar: Riedel’s thyroiditis: report of a case complicated by spontaneous hypoparathyroidism, recurrent laryngeal nerve injury, and Horner’s syndrome. J Clin Endocrinol Metab. 2002;87(8):3543–7.

    CAS  PubMed  Google Scholar 

  41. Stan MN, Haglind EG, Drake MT. Early hypoparathyroidism reversibility with treatment of Riedel’s thyroiditis. Thyroid. 2015;25(9):1055–9.

    Article  CAS  PubMed  Google Scholar 

  42. Hennessey JV. Riedel’s thyroiditis: a clinical review. J Clin Endocrinol Metab. 2011;96(10):3031–41.

    Article  CAS  PubMed  Google Scholar 

  43. Pritchyk K, Newkirk K, Garlich P, Deeb Z. Tamoxifen therapy for Riedel’s thyroiditis. Laryngoscope. 2004;114(10):1758–60.

    Article  PubMed  Google Scholar 

  44. Papi G, LiVolsi VA. Current concepts on Riedel thyroiditis. Pathol Patterns Rev. 2004;121(suppl_1):S50–63.

    Article  Google Scholar 

  45. Schwaegerle SM, Bauer TW, Esselstyn CB. Riedel’s thyroiditis. Am J Clin Pathol. 1988;90(6):715–22.

    Article  CAS  PubMed  Google Scholar 

  46. Hayashi Y, Tamai H, Fukata S, Hirota Y, Katayama S, Kuma K, et al. A long term clinical, immunological, and histological follow-up study of patients with goitrous chronic lymphocytic thyroiditis. J Clin Endocrinol Metab. 1985;61(6):1172–8.

    Article  CAS  PubMed  Google Scholar 

  47. Hegedüs L, Hansen JM, Feldt-Rasmussen U, Hansen BM, Høier-Madsen M. Influence of thyroxine treatment on thyroid size and anti-thyroid peroxidase antibodies in Hashimoto’s thyroiditis. Clin Endocrinol. 1991;35(3):235–8.

    Article  Google Scholar 

  48. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010;20(10):1163–73.

    Article  CAS  PubMed  Google Scholar 

  49. Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, et al. Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies. Clin Endocrinol. 2014;80(3):444–51.

    Article  CAS  Google Scholar 

  50. Larsen PR. Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. J Clin Invest. 1972;51(5):1125–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Few J, Thompson NW, Angelos P, Simeone D, Giordano T, Reeve T. Riedel’s thyroiditis: treatment with tamoxifen. Surgery. 1996;120(6):993–8; discussion 998-999.

    Article  CAS  PubMed  Google Scholar 

  52. Jung YJ, Schaub CR, Rhodes R, Rich FA, Muehlenbein SJ. A case of Riedel’s thyroiditis treated with tamoxifen: another successful outcome. Endocr Pract. 2004;10(6):483–6.

    Article  PubMed  Google Scholar 

  53. Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z. Riedel’s thyroiditis treated with tamoxifen. Croat Med J. 2003;44(2):239–41.

    PubMed  Google Scholar 

  54. Soh S-B, Pham A, O’Hehir RE, Cherk M, Topliss DJ. Novel use of rituximab in a case of Riedel’s thyroiditis refractory to glucocorticoids and tamoxifen. J Clin Endocrinol Metab. 2013;98(9):3543–9.

    Article  CAS  PubMed  Google Scholar 

  55. Shih M-L, Lee JA, Hsieh C-B, Yu J-C, Liu H-D, Kebebew E, et al. Thyroidectomy for Hashimoto’s thyroiditis: complications and associated cancers. Thyroid. 2008;18(7):729–34.

    Article  PubMed  Google Scholar 

  56. Wormer BA, McHenry CR. Hashimoto’s thyroiditis: outcome of surgical resection for patients with thyromegaly and compressive symptoms. Am J Surg. 2011;201(3):416–9; discussion 419.

    Article  PubMed  Google Scholar 

  57. Shimizu K, Nakajima Y, Kitagawa W, Akasu H, Takatsu K, Ishii R, et al. Surgical therapy in Hashimoto’s thyroiditis. J Nippon Med Sch. 2003;70(1):34–9.

    Article  PubMed  Google Scholar 

  58. Promberger R, Hermann M, Pallikunnel SJ, Seemann R, Meusel M, Ott J. Quality of life after thyroid surgery in women with benign euthyroid goiter: influencing factors including Hashimoto’s thyroiditis. Am J Surg. 2014;207(6):974–9.

    Article  PubMed  Google Scholar 

  59. Heggie K, Yeung M, Grodski S, Lee J, Serpell J. Total thyroidectomy for pressure symptoms in patients with Hashimoto’s thyroiditis. ANZ J Surg. 2018;88(4):359–62.

    Article  PubMed  Google Scholar 

  60. Guldvog I, Reitsma LC, Johnsen L, Lauzike A, Gibbs C, Carlsen E, et al. Thyroidectomy versus medical management for euthyroid patients with Hashimoto disease and persisting symptoms: a randomized trial. Ann Intern Med. 2019;170(7):453–64.

    Article  PubMed  Google Scholar 

  61. Thomusch O, Sekulla C, Billmann F, Seifert G, Dralle H, Lorenz K, et al. Risk profile analysis and complications after surgery for autoimmune thyroid disease. Br J Surg. 2018;105(6):677–85.

    Article  CAS  PubMed  Google Scholar 

  62. Holm L-E, Blomgren H, Löwhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Engl J Med. 1985;312(10):601–4.

    Article  CAS  PubMed  Google Scholar 

  63. Kato I, Tajima K, SucHI T, Aozasa K, Matsuzuka F. Chronic thyroiditis as a risk factor of B-cell lymphoma in the thyroid gland. Jpn J Cancer Res. 1985;76:1085.

    CAS  PubMed  Google Scholar 

  64. Pavlidis ET, Pavlidis TE. A review of primary thyroid lymphoma: molecular factors, diagnosis and management. J Investig Surg. 2019;32(2):137–42.

    Article  Google Scholar 

  65. Kossev P, Livolsi V. Lymphoid lesions of the thyroid: review in light of the revised European-American lymphoma classification and upcoming World Health Organization classification. Thyroid. 1999;9(12):1273–80.

    Article  CAS  PubMed  Google Scholar 

  66. Derringer GA, Thompson LD, Frommelt RA, Bijwaard KE, Heffess CS, Abbondanzo SL. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol. 2000;24(5):623–39.

    Article  CAS  PubMed  Google Scholar 

  67. Sharma A, Jasim S, Reading CC, Ristow KM, Villasboas Bisneto JC, Habermann TM, et al. Clinical presentation and diagnostic challenges of thyroid lymphoma: a cohort study. Thyroid. 2016;26(8):1061–7.

    Article  PubMed  Google Scholar 

  68. Aiken AH. Imaging of thyroid cancer. Semin Ultrasound CT MR. 2012;33(2):138–49.

    Article  PubMed  Google Scholar 

  69. Ravinsky E, Morales C. Diagnosis of lymphoma by image-guided needle biopsies: fine needle aspiration biopsy, core biopsy or both? Acta Cytol. 2005;49(1):51–7.

    Article  PubMed  Google Scholar 

  70. Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab. 2013;98(2):474–82.

    Article  CAS  PubMed  Google Scholar 

  71. McLeod DSA, Watters KF, Carpenter AD, Ladenson PW, Cooper DS, Ding EL. Thyrotropin and thyroid cancer diagnosis: a systematic review and dose-response meta-analysis. J Clin Endocrinol Metab. 2012;97(8):2682–92.

    Article  CAS  PubMed  Google Scholar 

  72. Larson SD, Jackson LN, Riall TS, Uchida T, Thomas RP, Qiu S, et al. Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k/Akt pathway. J Am Coll Surg. 2007;204(5):764–73; discussion 773–775.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Mechler C, Bounacer A, Suarez H, Saint Frison M, Magois C, Aillet G, et al. Papillary thyroid carcinoma: 6 cases from 2 families with associated lymphocytic thyroiditis harbouring RET/PTC rearrangements. Br J Cancer. 2001;85(12):1831–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Muzza M, Degl’Innocenti D, Colombo C, Perrino M, Ravasi E, Rossi S, et al. The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies. Clin Endocrinol. 2010;72(5):702–8.

    Article  CAS  Google Scholar 

  75. Unger P, Ewart M, Wang BY, Gan L, Kohtz DS, Burstein DE. Expression of p63 in papillary thyroid carcinoma and in Hashimoto’s thyroiditis: a pathobiologic link? Hum Pathol. 2003;34(8):764–9.

    Article  CAS  PubMed  Google Scholar 

  76. Anderson CE, Graham C, Herriot MM, Kamel HM, Salter DM. CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto’s thyroiditis. Histopathology. 2009;55(6):683–6.

    Article  PubMed  Google Scholar 

  77. Jara SM, Carson KA, Pai SI, Agrawal N, Richmon JD, Prescott JD, et al. The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma. Surgery. 2013;154(6):1272–80; discussion 1280–1282.

    Article  PubMed  Google Scholar 

  78. Liang J, Zeng W, Fang F, Yu T, Zhao Y, Fan X, et al. Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients. Acta Otorhinolaryngol Ital. 2017;37(5):393–400.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Kim EY, Kim WG, Kim WB, Kim TY, Kim JM, Ryu J-S, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol. 2009;71(4):581–6.

    Article  Google Scholar 

  80. Kashima K, Yokoyama S, Noguchi S, Murakami N, Yamashita H, Watanabe S, et al. Chronic thyroiditis as a favorable prognostic factor in papillary thyroid carcinoma. Thyroid. 1998;8(3):197–202.

    Article  CAS  PubMed  Google Scholar 

  81. Rossi ED, Adeniran AJ, Faquin WC. Pitfalls in thyroid cytopathology. Surg Pathol Clin. 2019;12(4):865–81.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Harvey AM, Truong LD, Mody DR. Diagnostic pitfalls of Hashimoto’s/Lymphocytic thyroiditis on fine-needle aspirations and strategies to avoid overdiagnosis. Acta Cytol. 2012;56(4):352–60.

    Article  PubMed  Google Scholar 

  83. Haberal AN, Toru S, Ozen O, Arat Z, Bilezikçi B. Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases. Cytopathology. 2009;20(2):103–8.

    Article  CAS  PubMed  Google Scholar 

  84. Berho M, Suster S. Clear nuclear changes in Hashimoto’s thyroiditis. A clinicopathologic study of 12 cases. Ann Clin Lab Sci. 1995;25(6):513–21.

    CAS  PubMed  Google Scholar 

  85. Ren Y, Kyriazidis N, Faquin WC, Soylu S, Kamani D, Saade R, et al. The presence of Hürthle cells does not increase the risk of malignancy in Most Bethesda categories in thyroid fine-needle aspirates. Thyroid. 2020;30(3):425–31.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Roh MH, Jo VY, Stelow EB, Faquin WC, Zou KH, Alexander EK, et al. The predictive value of the fine-needle aspiration diagnosis “suspicious for a follicular neoplasm, hurthle cell type” in patients with Hashimoto thyroiditis. Am J Clin Pathol. 2011;135(1):139–45.

    Article  PubMed  Google Scholar 

  87. Alexander EK, Kennedy GC, Baloch ZW, Cibas ES, Chudova D, Diggans J, et al. Preoperative diagnosis of benign thyroid nodules with indeterminate cytology. N Engl J Med. 2012;367(8):705–15.

    Article  CAS  PubMed  Google Scholar 

  88. McIver B, Castro MR, Morris JC, Bernet V, Smallridge R, Henry M, et al. An independent study of a gene expression classifier (Afirma) in the evaluation of cytologically indeterminate thyroid nodules. J Clin Endocrinol Metab. 2014;99(11):4069–77.

    Article  CAS  PubMed  Google Scholar 

  89. Lastra RR, Pramick MR, Crammer CJ, LiVolsi VA, Baloch ZW. Implications of a suspicious afirma test result in thyroid fine-needle aspiration cytology: an institutional experience. Cancer Cytopathol. 2014;122(10):737–44.

    Article  PubMed  Google Scholar 

  90. Harrell RM, Bimston DN. Surgical utility of Afirma: effects of high cancer prevalence and oncocytic cell types in patients with indeterminate thyroid cytology. Endocr Pract. 2014;20(4):364–9.

    Article  PubMed  Google Scholar 

  91. Angell TE, Heller HT, Cibas ES, Barletta JA, Kim MI, Krane JF, et al. Independent comparison of the Afirma genomic sequencing classifier and gene expression classifier for cytologically indeterminate thyroid nodules. Thyroid. 2019;29(5):650–6.

    Article  CAS  PubMed  Google Scholar 

  92. Endo M, Nabhan F, Porter K, Roll K, Shirley LA, Azaryan I, et al. Afirma gene sequencing classifier compared with gene expression classifier in indeterminate thyroid nodules. Thyroid. 2019;29(8):1115–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Hwang HS, Orloff LA. Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer. Laryngoscope. 2011;121(3):487–91.

    Article  PubMed  Google Scholar 

  94. Serres-Créixams X, Castells-Fusté I, Pruna-Comella X, Yetano-Laguna V, Garriga-Farriol V, Gallardo-Agromayor E. Paratracheal lymph nodes: a new sonographic finding in autoimmune thyroiditis. J Clin Ultrasound. 2008;36(7):418–21.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Head and Neck Surgery, Division of Head and Neck Oncologic and Endocrine Surgery, University of California, San Francisco, CA, USA

    Marika D. Russell

  2. Head and Neck Surgery, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA

    Marika D. Russell

  3. Division of Endocrinology, Department of Medicine, University of California, San Francisco, CA, USA

    Janet Chiang

  4. Zuckerberg San Francisco General Hospital, San Francisco VA Medical Center, San Francisco, CA, USA

    Janet Chiang

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  1. Marika D. Russell
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Correspondence to Marika D. Russell .

Editor information

Editors and Affiliations

  1. Department of Surgery, Jersey Shore University Medical Center, Neptune, NJ, USA

    Alexander L. Shifrin

  2. Division of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

    Marco Raffaelli

  3. The Claire and John Bertucci Endowed Chair in Thyroid Surgical Oncology, Harvard Medical School, Boston, MA, USA

    Gregory W. Randolph

  4. Department of Surgery, Linkö** University, Linkö**, Sweden

    Oliver Gimm

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Russell, M.D., Chiang, J. (2021). Diagnosis and Management of Thyroiditis: Hashimoto, de Quervain, Riedel. In: Shifrin, A.L., Raffaelli, M., Randolph, G.W., Gimm, O. (eds) Endocrine Surgery Comprehensive Board Exam Guide. Springer, Cham. https://doi.org/10.1007/978-3-030-84737-1_4

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