Abstract
The transition process from pediatric to adult transplant units is still characterized by an overall lack of consistency in the healthcare and support services provided to young people with pediatric liver disease who have undergone liver transplantation (LT). Data on the long-term survival of liver transplant adolescents (LTAs) continue to improve, but evidence shows that after transition, it is hampered by a decreased adherence to medical therapy with a consequent significant higher risk of rejection and potential graft loss. The risk factors related to nonadherence in adolescence are multiple and include issues intrinsic to the “physiological” adolescence itself, psychological distress, alcohol or drug abuse, integrity of the family, and impact of immunosuppressive drugs side effects on physical appearance, which need all careful attention by adulthood providers. Here we provide some useful available recent information to pediatric/adult hepatologists and practitioners who are responsible for ensuring LTAs’ continuity of care.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Acuña Mora M, Saarijärvi M, Moons P, Sparud-Lundin C, Bratt EL, Goossens E. The scope of research on transfer and transition in young persons with chronic conditions. J Adolesc Health. 2019;65:581–9. https://doi.org/10.1016/j.jadohealth.2019.07.014.
Vajro P, Fischler B, Burra P, et al. The health care transition of youth with liver disease into the adult health system: position paper from ESPGHAN and EASL. J Pediatr Gastroenterol Nutr. 2018;66:976–90. https://doi.org/10.1097/MPG.0000000000001965.
Junge N, Migal K, Goldschmidt I, et al. Transition after pediatric liver transplantation-perceptions of adults, adolescents and parents. World J Gastroenterol. 2017;23:2365–75. https://doi.org/10.3748/wjg.v23.i13.2365.
Guercio Nuzio S, Fischler B, Baumann U, et al. Transition of adolescents with pediatric-onset hepatobiliary diseases: systematic review of literature. 51th ESPGHAN Annual Meeting, Geneve, May 2018. J Pediatr Gastroenterol Hepatol. 2018;66(Suppl 2):749.
Brooks AJ, Smith PJ, Cohen R, et al. UK guideline on transition of adolescent and young persons with chronic digestive diseases from pediatric to adult care. Gut. 2017;66:988–1000. https://doi.org/10.1136/gutjnl-2016-313000.
Quintero J, Juampérez J, Mercadal-Hally M, et al. Transition to adult care for pediatric liver transplant recipients. Transplant Proc. 2020;52:1496–9. https://doi.org/10.1016/j.transproceed.2020.02.056.
Guercio Nuzio S, Tizzard SA, Vajro P. Tips and hints for the transition: what adult hepatologists should know when accept teens with a pediatric hepatobiliary disease. Clin Res Hepatol Gastroenterol. 2014;38:277–83. https://doi.org/10.1016/j.clinre.2014.03.012.
Wright J, Elwell L, McDonagh J, et al. Healthcare transition in pediatric liver transplantation: the perspectives of pediatric and adult healthcare professionals. Pediatr Transplant. 2019;23:e13530. https://doi.org/10.1111/petr.13530.
Vajro P, Ferrante L, Lenta S, et al. Management of adults with pediatric-onset chronic liver disease: strategic issues for transition care. Dig Liver Dis. 2014;46:295–301. https://doi.org/10.1016/j.dld.2013.10.018.
Kelly D, Wray J. Non-adherence and transition clinics. Best Pract Res Clin Gastroenterol. 2020;46-47:101687. https://doi.org/10.1016/j.bpg.2020.101687.
Fischler B, Dezsofi A, Dhawan A, et al. Paediatric and adult hepatologists views upon the transition of adolescents with chronic hepatobiliary disease: preliminary data of a European survey. 48th ESPGHAN Annual Meeting, Amsterdam, May 2015. J Gastroenterol Hepatol. 2015;60 Suppl:e607.
Heldman MR, Sohn MW, Gordon EJ, et al. National survey of adult transplant hepatologists on the pediatric-to-adult care transition after liver transplantation. Liver Transpl. 2015;21:213–23. https://doi.org/10.1002/lt.24044.
Ferrarese A, Germani G, Lazzaro S, et al. Short-term outcomes of pediatric liver transplant recipients after transition to Adult Healthcare Service. Liver Int. 2018;38:1316–21. https://doi.org/10.1111/liv.13655.
Ng VL, Mazariegos GV, Kelly B, et al. Barriers to ideal outcomes after pediatric liver transplantation. Pediatr Transplant. 2019;23:e13537. https://doi.org/10.1111/petr.13537.
Web Resources on Transition to Adult Care. The American Society of Transplantation (AST). https://www.myast.org/communities-practice/pediatric/web-resources-transition-adult-care. Assessed Oct 2020.
Christina S, Annunziato RA, Schiano TD, et al. Medication level variability index predicts rejection, possibly due to nonadherence, in adult liver transplant recipients. Liver Transpl. 2014;20:1168–77. https://doi.org/10.1002/lt.23930.
Shemesh E, Bucuvalas JC, Anand R, et al. The Medication Level Variability Index (MLVI) predicts poor liver transplant outcomes: a prospective multi-site study. Am J Transplant. 2017;17:2668–78. https://doi.org/10.1111/ajt.14276.
Pham YH, Miloh T. Liver transplantation in children. Clin Liver Dis. 2018;22:807–21. https://doi.org/10.1016/j.cld.2018.06.004.
Hassan S, Ng VL, Aqul A. It takes a village: primary care of the pediatric liver transplant recipient. Curr Opin Pediatr. 2019;31:636–44. https://doi.org/10.1097/MOP.0000000000000809.
Alisi A, Balsano C, Bernabucci V, et al. AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF). Dig Liver Dis. 2016;48:860–8. https://doi.org/10.1016/j.dld.2016.04.009.
Westbrook RH, Dusheiko G, Williamson CJ. Pregnancy and liver disease. J Hepatol. 2016;64:933–45. https://doi.org/10.1016/j.jhep.2015.11.030.
Kociszewska-Najman B, Mazanowska N, Pietrzak B, et al. Low transfer of tacrolimus and its metabolites into colostrum of graft recipient mothers. Nutrients. 2018;10(3) https://doi.org/10.3390/nu10030267.
Hebert MF, Zheng S, Hays K, et al. Interpreting tacrolimus concentrations during pregnancy and postpartum. Transplantation. 2013;95:908–15. https://doi.org/10.1097/TP.0b013e318278d367.
Clemente MG, Antonucci R, Mandato C, et al. Autoantibodies against CYP-2C19: a novel serum marker in pediatric de novo autoimmune hepatitis? Biomed Res Int. 2017;2017:3563278. https://doi.org/10.1155/2017/3563278.
Keitel V, Burdelski M, Vojnisek Z, et al. De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis. Hepatology. 2009;50:510–7. https://doi.org/10.1002/hep.23083.
Åberg F, Isoniemi H, Pukkala E, et al. Cancer after liver transplantation in children and young adults: a population-based study from 4 nordic countries. Liver Transpl. 2018;24:1252–9. https://doi.org/10.1002/lt.25305.
Hackl C, Schlitt HJ, Melter M, Knoppke B, Loss M. Current developments in pediatric liver transplantation. World J Hepatol. 2015;7:1509–20. https://doi.org/10.4254/wjh.v7.i11.1509.
Perito ER, Vase T, Ramachandran R, et al. Hepatic steatosis after pediatric liver transplant. Liver Transpl. 2017;23:957–67. https://doi.org/10.1002/lt.24773.
Blöte R, Memaran N, Borchert-Mörlins B, et al. Greater susceptibility for metabolic syndrome in pediatric solid organ and stem cell transplant recipients. Transplantation. 2019;103:2423–33. https://doi.org/10.1097/TP.0000000000002675.
Naeser V, Brandt AH, Nyhuus B, Borgwardt L, Jørgensen MH, Rasmussen A. Risk markers for later cardiovascular diseases in liver-transplanted children and adolescents. Pediatr Transplant. 2018;22:e13298. https://doi.org/10.1111/petr.13298.
Rothbaum Perito E, Lau A, Rhee S, Roberts JP, Rosenthal P. Posttransplant metabolic syndrome in children and adolescents after liver transplantation: a systematic review. Liver Transpl. 2012;18:1009–28. https://doi.org/10.1002/lt.23478.
Nobili V, de Ville de Goyet J. Pediatric post-transplant metabolic syndrome: new clouds on the horizon. Pediatr Transplant. 2013;17:216–23. https://doi.org/10.1111/petr.12065.
Perito ER, Lustig RH, Rosenthal P. Prediabetes in pediatric recipients of liver transplant: mechanism and risk factors. J Pediatr. 2017;182:223–31. https://doi.org/10.1016/j.jpeds.2016.11.070.
White PH, Cooley WC, Transitions Clinical Report Authoring Group; American Academy of Pediatrics; American Academy of Family Physicians; American College of Physicians. Supporting the health care transition from adolescence to adulthood in the medical home. Pediatrics. 2018;142 https://doi.org/10.1542/peds.2018-2587.
Further Reading
Antonini TM, Girard M, Habes D, et al. Optimization of the transition process of youth with liver disease in adulthood: a position paper from FILFOIE, the French network for paediatric and adult rare liver diseases. Clin Res Hepatol Gastroenterol. 2020;44:135–41. https://doi.org/10.1016/j.clinre.2019.07.018.
(Recommendations and tools designed to optimise the transition process focus on 3 key time points: preparation before the transfer, the transfer process to the adult service, and finally reception and follow-up within the adult-care service)
Lawrence ZE, Martinez M, Lobritto S, et al. Adherence, medical outcomes, and health care costs in adolescents/young adults following pediatric liver transplantation. J Pediatr Gastroenterol Nutr. 2020;70:183–9. https://doi.org/10.1097/MPG.0000000000002553.
(The time around transition from pediatric to adult health care models represents a period of increased vulnerability for pediatric LT recipients).
Nakanishi C, Miyagi S, Tokodai K, et al. Pediatric living-donor liver transplant recipients without transition after reaching adulthood. Ann Transplant. 2019;24:18–24. https://doi.org/10.12659/AOT.911544.
(Having the same team perform both adult and pediatric transplantation and post-transplant care appears beneficial for young adult recipients).
Nasr AS, Rehm RS. Understanding the long-term impact of living-related liver transplantation on youth and young adults and their family. J Pediatr Nurs. 2020;55:217–23. https://doi.org/10.1016/j.pedn.2020.09.004.
(Qualitative/quantitative data show positive effect of living-related liver donation on pediatric patients as they transition from childhood to adolescence/young adulthood).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Mandato, C., Guercio Nuzio, S., Vajro, P. (2022). Transition to Adult Care: Adolescents Care. In: Burra, P. (eds) Textbook of Liver Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-82930-8_34
Download citation
DOI: https://doi.org/10.1007/978-3-030-82930-8_34
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-82929-2
Online ISBN: 978-3-030-82930-8
eBook Packages: MedicineMedicine (R0)