Levetiracetam

  • Chapter
  • First Online:
Antiseizure Medication Interactions
  • 760 Accesses

Abstract

The pharmacokinetic characteristics of levetiracetam are described, and the interaction effects of concomitant antiseizure medications on levetiracetam in terms of its pharmacokinetics and pharmacodynamics are highlighted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now
Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 96.29
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 128.39
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Moseley BD, Otoul C, Staelens L, Stockis A. Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: pooled analysis of data from randomized clinical trials. Epilepsy Res. 2019;158:106218.

    Article  CAS  Google Scholar 

  2. Biton V, Berkovic SF, Abou-Khalil B, Sperling MR, Johnson ME, Lu S. Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trial. Epilepsia. 2014;55:57–66.

    Article  CAS  Google Scholar 

  3. Gaston TE, Bekib EM, Cutter GR, Liu Y, Szaflarski JP, UAB CBD Program. Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017;58:1586–92.

    Article  CAS  Google Scholar 

  4. Aldaz A, Alzueta N, Viteri C. Influence of comedication on levetiracetam pharmacokinetics. Ther Drug Monit. 2018;40:130–4.

    Article  CAS  Google Scholar 

  5. Sisodiya SM, Sander JW, Patsalos PN. Carbamazepine toxicity during combination therapy with levetiracetam: a pharmacodynamic interaction. Epilepsy Res. 2002;48:217–9.

    Article  CAS  Google Scholar 

  6. Summary of product characteristics: Cenobamate (XCopri). SK Life Science Inc. Last update Aug 2020.

    Google Scholar 

  7. Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet. 2004;43:707–24.

    Article  CAS  Google Scholar 

  8. Falcao A, Fuseau E, Nunes T, Almeida L, Soares-da-Silva P. Pharmacokinetics, drug interactions and exposure-response relationships of eslicarbazepine acetate in adult patients with partialonset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis. CNS Drugs. 2012;26:79–91.

    Article  CAS  Google Scholar 

  9. Glauser TA, Pellock JM, Bebin EM, Fountain NB, Ritter FJ, Jensen CB, Shields WD. Efficacy and safety of levetiracetam in children with partial seizures: an open-label trial. Epilepsia. 2002;43:518–24.

    Article  CAS  Google Scholar 

  10. Toutopoulou M, Weshke B, Kaindl AM. Lacsamide lowers valproate and levetiracetam levels. Neuropediatrics. 2017;48:188–9.

    Article  Google Scholar 

  11. May TW, Rambeck B, Jurgens U. Serum concentrations of levetiracetam in epileptic patients: the influence of dose and co-medication. Ther Drug Monit. 2003;25:690–9.

    Article  CAS  Google Scholar 

  12. Majid O, Laurenza A, Ferry J, Hussein Z. Impact of perampanel on pharmacokinetics of concomitant antiepileptics in patients with partial-onset: pooled analysis of clinical trials. Br J Clin Pharmacol. 2016;82:422–30.

    Article  CAS  Google Scholar 

  13. Gidal BE, Ferry J, Majid O, Hussein Z. Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures. Epilepsia. 2013;54:1490–7.

    Article  CAS  Google Scholar 

  14. Patsalos PN. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol Ther. 2000;85:77–85.

    Article  CAS  Google Scholar 

  15. Summary of product characteristics: Stiripentol (Diacomit). Alan Pharmceuticals. Last update 20 Sept 2018.

    Google Scholar 

  16. Patsalos PN. Levetiracetam: pharmacology and therapeutics in the treatment of epilepsy and other neurological conditions. Rev Contemp Pharmacother. 2004;13:1–168.

    CAS  Google Scholar 

  17. Coupez R, Nicolas JM, Browne TR. Levetiracetam, a new antiepileptic agent: lack of in vitro and in vivo pharmacokinetic interaction with valproic acid. Epilepsia. 2003;44:171–8.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philip N. Patsalos .

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Patsalos, P.N. (2022). Levetiracetam. In: Antiseizure Medication Interactions. Springer, Cham. https://doi.org/10.1007/978-3-030-82790-8_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-82790-8_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-82789-2

  • Online ISBN: 978-3-030-82790-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation