Lacosamide

  • Chapter
  • First Online:
Antiseizure Medication Interactions
  • 732 Accesses

Abstract

The pharmacokinetic characteristics of lacosamide are described, and the interaction effects of concomitant antiseizure medications on lacosamide in terms of its pharmacokinetics and pharmacodynamics are highlighted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Moseley BD, Otoul C, Staelens L, Stockis A. Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: pooled analysis of data from randomized clinical trials. Epilepsy Res. 2019;158:106218.

    Article  CAS  Google Scholar 

  2. Gaston TE, Bekib EM, Cutter GR, Liu Y, Szaflarski JP, UAB CBD Program. Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017;58:1586–92.

    Article  CAS  Google Scholar 

  3. Markoula S, Teotonio R, Ratnaraj N, Duncan JS, Sander JW, Patsalos PN. Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. Ther Drug Monit. 2014;36:494–8.

    Article  CAS  Google Scholar 

  4. Contin M, Albani F, Riva R, Candela C, Mohamed S, Baruzzi A. Lacosamide therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. Ther Drug Monit. 2013;35:849–52.

    Article  CAS  Google Scholar 

  5. Novy J, Patsalos PN, Sander JW, Sisodiya SM. Lacosamide neurotoxicity associated with concomitant use of sodium-blocking antiepileptic drugs: a pharmacodynamic interaction? Epilepsy Behav. 2011;20:20–3.

    Article  Google Scholar 

  6. Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Perucca P, Tomson T, White HS. Progress report on new antiepiletis drugs: a summary of the fifteenth Eilat conference on new antiepileptic drugs and devices (EILAT XV). II. Drugs in more advanced clinical development. Epilepsia. 2020;61:2365–85.

    Article  CAS  Google Scholar 

  7. Thomas D, Scharfenecker U, Schiltmeyer B, Doty P, Cawello W, Horstmann R. Low potential for drug-drug interactions of lacosamide. Epilepsia. 2006;47(Suppl 4):200.

    Google Scholar 

  8. May TW, Helmer R, Bien CG, Brandt C. Influence of dose and antiepileptic comedication on lacosamide serum concentrations in patients with epilepsy of different ages. Ther Drug Monit. 2018;40:620–7.

    Article  CAS  Google Scholar 

  9. Nickel B, Zisowsky J, Cawello W, Lovern M, Sargentini-Maier ML. Population pharmacokinetics of LCM in subjects with partial onset seizures: results from two phase III trials. J Clin Pharmacol. 2008;48:1129.

    Google Scholar 

  10. Cawello W, Bonn R. No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteers. J Clin Pharmacol. 2012;52:1739–48.

    Article  CAS  Google Scholar 

  11. Jones GL, Popli GS, Silvia MT. Lacosamide-induced valproic acid toxicity. Pediatr Neurol. 2013;48:308–10.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philip N. Patsalos .

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Patsalos, P.N. (2022). Lacosamide. In: Antiseizure Medication Interactions. Springer, Cham. https://doi.org/10.1007/978-3-030-82790-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-82790-8_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-82789-2

  • Online ISBN: 978-3-030-82790-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation