Felbamate

  • Chapter
  • First Online:
Antiseizure Medication Interactions
  • 707 Accesses

Abstract

The pharmacokinetic characteristics of felbamate are described, and the interaction effects of concomitant antiseizure medications on felbamate in terms of its pharmacokinetics and pharmacodynamics are highlighted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now
Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 96.29
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 128.39
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Wagner ML, Graves NM, Marienau K, Holmes GB, Remmel RP, Leppik IE. Discontinuation of phenytoin and carbamazepine in patients receiving felbamate. Epilepsia. 1991;32:398–406.

    Article  CAS  Google Scholar 

  2. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Clin Pharmacokinet. 1997;33:214–24.

    Article  CAS  Google Scholar 

  3. Hussein G, Troupin AS, Montouris G. Gabapentin interaction with felbamate. Neurology. 1996;47:1106.

    Article  CAS  Google Scholar 

  4. Colucci R, Glue P, Holt B, Babfield C, Reidenberg P, Meechan JW, Pai S, Nomeir A, Lim J, Lin CC, Affrime MB. Effect of felbamate on the pharmacokinetics of lamotrigine. J Clin Pharmacol. 1996;36:634–8.

    Article  CAS  Google Scholar 

  5. Hulsman JARJ, Rentmeester TW, Banfield CR, Reidenberg P, Colucci RD, Meehan JW, Radwanski E, Mojavarian P, Lin CC, Nezamis J, Affrime MB, Glue P. Effects of felbamate on the pharmacokinetics of the monohydroxy and dihydroxy metabolites of oxcarbazepine. Clin Pharmacol Ther. 1995;58:383–9.

    Article  CAS  Google Scholar 

  6. Kelley MT, Walson PD, Cox S, Dusci LJ. Population pharmacokinetics of felbamate in children. Ther Drug Monit. 1997;19:29–36.

    Article  CAS  Google Scholar 

  7. Wagner ML, Graves NM, Leppik IE, Remmel RP, Shmaker RC, Ward D, Perhach JL. The effect of felbamate on valproic acid disposition. Clin Pharmacol Ther. 1994;56:494–502.

    Article  CAS  Google Scholar 

  8. Reidenberg P, Glue P, Banfield C, Colucci R, Meehan J, Rey E, Radwanski E, Nomeir A, Lim J, Lin C, Guillaume M, Affrime MB. Pharmacokinetic interaction studies between felbamate and vigabatrin. Br J Clin Pharmacol. 1995;40:157–60.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philip N. Patsalos .

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Patsalos, P.N. (2022). Felbamate. In: Antiseizure Medication Interactions. Springer, Cham. https://doi.org/10.1007/978-3-030-82790-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-82790-8_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-82789-2

  • Online ISBN: 978-3-030-82790-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation