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Management and Modulation of Cholinesterase

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Toxicology of Organophosphate Poisoning

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Abstract

Inhibition of cholinesterases is the key by which organophosphates (OP) exert their toxic effects on the target organism. Humans are affected by OP poisoning by both acute (intentional and unintentional) and chronic toxicity. Phosphorylation of AChE at serine residue in the catalytic gorge is leading to the formation of AChE-OP adduct. Reactivation of AChE by self is nearly impossible. Oximes are potent reactivators of AChE. Bioscavenging the OP available in the bloodstream is an alternate way of protecting endogenous cholinesterases. This chapter has discussed the management of AChE by means of reactivation, bioscavenging using stoichiometric and catalytic bioscavengers, and nanotechnological approaches. The possibility of reactivation of aged AChE has also been discussed.

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  1. Amity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida, Uttar Pradesh, India

    Anuj Ranjan & Tanu **dal

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  1. Anuj Ranjan
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  2. Tanu **dal
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Ranjan, A., **dal, T. (2022). Management and Modulation of Cholinesterase. In: Toxicology of Organophosphate Poisoning. Springer, Cham. https://doi.org/10.1007/978-3-030-79128-5_4

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