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National Science Foundation Engineering Research Center for Cell Manufacturing Technologies (CMaT)

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Cell Therapy

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Abstract

The National Science Foundation-funded Engineering Research Center (ERC) for Cell Manufacturing Technologies (CMaT) and the philanthropically funded Marcus Center for Therapeutic cell Characterization and Manufacturing (MC3M) are two national centers focused on develo** new engineering and computational tools to advance the scalable manufacture of cell-based therapies into a reproducible, lower-cost, consistent, high-quality industry product for broad clinical use. These centers have developed a robust infrastructure for academia, industry, and government organizations to work together towards deep cell characterization, multi-omics-driven predictive modeling of critical quality attributes and critical process parameters, standards and best practices development, innovative process analytical technologies, scale-up or scale-out technologies, and robust supply chain management. This chapter provides an overview of these supporting organizations in the current cell therapy manufacturing ecosystem.

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Acknowledgments

Supporting organizations: This work was partially supported by NSF Grant EEC 1648035 for the Engineering Research Center (ERC) for Cell Manufacturing Technologies (CMaT) and the Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M) at Georgia Tech. The authors would like to thank all CMaT and MC3M faculty, staff, and trainees for their immense contribution to the work described here.

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Authors and Affiliations

  1. NSF Engineering Research Center for Cell Manufacturing Technologies (CMaT), Atlanta, GA, USA

    Punya Mardhanan, Johnna Temenoff, Sean Palecek, Aaron Levine, Felicia Benton-Johnson, Manu Platt, Carolyn Yeago & Krishnendu Roy

  2. The Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M), Georgia Institute of Technology, Atlanta, GA, USA

    Punya Mardhanan, Carolyn Yeago & Krishnendu Roy

  3. The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, and the Parker H. Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, Atlanta, GA, USA

    Johnna Temenoff, Manu Platt & Krishnendu Roy

  4. Department of Chemical and Biological Engineering, University of Wisconsin – Madison, Madison, WI, USA

    Sean Palecek

  5. School of Public Policy, The Ivan Allen College of Liberal Arts, Georgia Institute of Technology, Atlanta, GA, USA

    Aaron Levine

  6. Center for Engineering Education and Diversity (CEED), College of Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Felicia Benton-Johnson

Authors
  1. Punya Mardhanan
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  2. Johnna Temenoff
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  3. Sean Palecek
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  4. Aaron Levine
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  5. Felicia Benton-Johnson
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  6. Manu Platt
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  7. Carolyn Yeago
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  8. Krishnendu Roy
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Corresponding author

Correspondence to Krishnendu Roy .

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Editors and Affiliations

  1. Texas Children’s Cancer Center, Center for Cell and Gene Therapy, Houston, TX, USA

    Adrian P. Gee

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Mardhanan, P. et al. (2022). National Science Foundation Engineering Research Center for Cell Manufacturing Technologies (CMaT). In: Gee, A.P. (eds) Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-75537-9_39

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