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Positron Emission Tomography (PET) Imaging Based on Sub-millimeter Pixelated CdZnTe Detectors

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Advanced X-ray Detector Technologies

Abstract

This chapter examines positron emission tomography (PET) imaging applications using sub-millimeter pixelated cadmium zinc telluride (CdZnTe) detectors. We first discuss the current state of the field and then present recent finds from our own studies. CdZnTe detectors with 0.35 mm and 0.6 mm pitch pixels were fabricated with pixel anodes and coplanar cathode. The characterizations of CdZnTe detectors for PET imaging are analyzed in detail, including 3D spatial resolution, the depth of interaction, charge sharing, timing resolution, and imaging resolution. For positron-annihilated 511 keV gamma ray photons, the single-pixel event profile of the 0.35 mm pitch pixelated CdZnTe detector exhibited a spatial resolution of 0.41 mm FWHM; and the double-pixel charge-sharing event profile had a spatial resolution of 0.52 mm FWHM. Imaging experiments have demonstrated that a PET scanner made of 0.35 mm pitch pixelated CdZnTe detectors can improve the image resolution of PET scanner to 0.5 mm. To narrow the coincidence timing window of CdZnTe PET scanner, a time correction method to the long charge drift time of CdZnTe detector was introduced. To include the coincidence events of the double-pixel charge-sharing events from CdZnTe, an interpolation algorithm for the location of charge-sharing events was developed. Researches indicate that the CdZnTe detector is a promising candidate for sub-millimeter high-resolution PET imaging applications.

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Authors and Affiliations

  1. School of Nuclear Science and Technology, Lanzhou University, Lanzhou, China

    Yongzhi Yin

  2. Department of Radiology, Washington University, St. Louis, MO, USA

    Sergey Komarov

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  1. Yongzhi Yin
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  2. Sergey Komarov
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Correspondence to Yongzhi Yin .

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  1. Emerging Technologies CMOS Inc., Port Moody, BC, Canada

    Krzysztof (Kris) Iniewski

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Yin, Y., Komarov, S. (2022). Positron Emission Tomography (PET) Imaging Based on Sub-millimeter Pixelated CdZnTe Detectors. In: Iniewski, K.(. (eds) Advanced X-ray Detector Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-64279-2_12

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  • DOI: https://doi.org/10.1007/978-3-030-64279-2_12

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