Starting Antiseizure Medication

  • Chapter
  • First Online:
Epilepsy Case Studies
  • 888 Accesses

Abstract

The goal of starting antiseizure medication (ASM) is for the patient to have no further seizures and no significant side effects. At the time of presentation, additional clinical and laboratory testing is typically needed to determine the risk of seizure recurrence. Though early versus delayed initiation of an ASM does not necessarily affect the natural history of epilepsy, it may impact the short-term risk of seizure recurrence. Ultimately, the ASM selected needs to be appropriate for the suspected seizure classification: focal versus generalized. The next consideration is to weigh possible adverse effects and to consider those in the context of an individual patient’s comorbidities. Both the risk of seizure recurrence and potential side effects from ASM need to be discussed with the patient at the time of drug initiation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 84.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Hesdorffer DC, Benn EK, Cascino GD, Hauser WA. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia. 2009;50(5):1102–8.

    Article  Google Scholar 

  2. Krumholz A, Wiebe S, Gronseth GS, Gloss DS, Sanchez AM, Kabir AA, et al. Evidence-based guideline: management of an unprovoked first seizure in adults: report of the guideline development subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsy Curr. 2015;15(3):144–52.

    Article  CAS  Google Scholar 

  3. Hauser WA, Rich SS, Lee JR, Annegers JF, Anderson VE. Risk of recurrent seizures after two unprovoked seizures. N Engl J Med. [Research Support, U.S. Gov’t, P.H.S.]. 1998;338(7):429–34.

    Article  CAS  Google Scholar 

  4. Marson A, Jacoby A, Johnson A, Kim L, Gamble C, Chadwick D. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet. [Clinical Trial Comparative Study Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov’t]. 2005;365(9476):2007–13.

    Article  CAS  Google Scholar 

  5. Kim LG, Johnson TL, Marson AG, Chadwick DW. Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial. Lancet Neurol. [Clinical Trial Comparative Study Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov’t]. 2006;5(4):317–22.

    Article  Google Scholar 

  6. Crepeau AZ, Sirven JI. Management of adult onset seizures. Mayo Clin Proc. [Review]. 2017;92(2):306–18.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amy Z. Crepeau .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Crepeau, A.Z. (2021). Starting Antiseizure Medication. In: Tatum, W.O., Sirven, J.I., Cascino, G.D. (eds) Epilepsy Case Studies. Springer, Cham. https://doi.org/10.1007/978-3-030-59078-9_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-59078-9_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-59077-2

  • Online ISBN: 978-3-030-59078-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation