Introduction to Essential Oils and Essential Oil Processing

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Integrative Dermatology

Abstract

In the treatment of acne and rosacea, several essential oils may play a therapeutic role via both antimicrobial and anti-inflammatory pathways. The particular microbial target in acne vulgaris appears to be the Cutibacterium acnes bacterium. Essential oils investigated for this review include tea tree oil, Oregon grape root oil, pomegranate seed oil, rosemary oil, witch hazel, rose oil, rosehip oil, orange/citrus oil, Korean fir oil, frankincense oil, chamomile oil, clary sage oil, lavender oil, ylang-ylang oil, juniper berry oil, and clove basil oil. Many of these essential oils need a carrier oil to avoid evaporation, and carrier oils reviewed here include olive oil, jojoba, coconut, sesame seed, grape seed, sweet almond, and sunflower seed oil. Of those listed, tea tree oil is the most common and well-known essential oil with evidence available in both acne and rosacea treatments.

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References

  1. Winkelman WJ. Aromatherapy, botanicals, and essential oils in acne. Clin Dermatol. 2018;36(3):299–305.

    Article  PubMed  Google Scholar 

  2. Herman A, Herman AP. Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review. J Pharm Pharmacol. 2015;7(4):473–85.

    Article  CAS  Google Scholar 

  3. Li Y, Fabiano-Tixier A-S, Chemat F. Essential oils: from conventional to green extraction. In: Essential oils as reagents in green chemistry. Cham: Springer; 2014. p. 9–20.

    Google Scholar 

  4. Schnaubelt K. Biology of essential oils. San Rafael: Terra Linda Scent and Image; 2002.

    Google Scholar 

  5. Guenther E. The essential oils. New York: D. Van Nostrand Company, Inc.; 1948.

    Google Scholar 

  6. Orchard A, van Vuuren S. Commercial essential oils as potential antimicrobials to treat skin diseases. Evid Based Complement Alternat Med. 2017;2017:4517971.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Olutunmbi Y, Paley K, English JC 3rd. Adolescent female acne: etiology and management. J Pediatr Adolesc Gynecol. 2008;21(4):171–6.

    Article  PubMed  Google Scholar 

  8. Taylor EJ, Yu Y, Champer J, Kim J. Resveratrol demonstrates antimicrobial effects against propionibacterium acnes in vitro. Dermatol Ther. 2014;4(2):249–57.

    Article  Google Scholar 

  9. Fisk WA, Lev-Tov HA, Sivamani RK. Botanical and phytochemical therapy of acne: a systematic review. Phytother Res. 2014;28(8):1137–52.

    Article  PubMed  Google Scholar 

  10. Carson CF, Mee BJ, Riley TV. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrob Agents Chemother. 2002;46(6):1914–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sharifi-Rad J, Salehi B, Varoni EM, Sharopov F, Yousaf Z, Ayatollahi SA, et al. Plants of the Melaleuca genus as antimicrobial agents: from farm to pharmacy. Phytother Res. 2017;31(10):1475–94.

    Article  CAS  PubMed  Google Scholar 

  12. Armstrong AW, Cheeney S, Wu J, Harskamp CT, Schupp CW. Harnessing the power of crowds: crowdsourcing as a novel research method for evaluation of acne treatments. Am J Clin Dermatol. 2012;13(6):405–16.

    Article  PubMed  Google Scholar 

  13. Hammer KA. Treatment of acne with tea tree oil (melaleuca) products: a review of efficacy, tolerability and potential modes of action. Int J Antimicrob Agents. 2015;45(2):106–10.

    Article  CAS  PubMed  Google Scholar 

  14. Brady A, Loughlin R, Gilpin D, Kearney P, Tunney M. In vitro activity of tea-tree oil against clinical skin isolates of meticillin-resistant and -sensitive Staphylococcus aureus and coagulase-negative staphylococci growing planktonically and as biofilms. J Med Microbiol. 2006;55(Pt 10):1375–80.

    Article  CAS  PubMed  Google Scholar 

  15. de Groot AC, Schmidt E. Tea tree oil: contact allergy and chemical composition. Contact Dermatitis. 2016;75(3):129–43.

    Article  PubMed  CAS  Google Scholar 

  16. McMahon M, Tunney M, Moore J, Blair I, Gilpin D, McDowell D. Changes in antibiotic susceptibility in staphylococci habituated to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia). Lett Appl Microbiol. 2008;47(4):263–8.

    Article  CAS  PubMed  Google Scholar 

  17. He JM, Mu Q. The medicinal uses of the genus Mahonia in traditional Chinese medicine: an ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol. 2015;175:668–83.

    Article  CAS  PubMed  Google Scholar 

  18. Slobodnikova L, Kost’alova D, Labudova D, Kotulova D, Kettmann V. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phytother Res. 2004;18(8):674–6.

    Article  CAS  PubMed  Google Scholar 

  19. Gulliver WP, Donsky HJ. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Am J Ther. 2005;12(5):398–406.

    Article  PubMed  Google Scholar 

  20. Muller K, Ziereis K. The antipsoriatic Mahonia aquifolium and its active constituents; I. Pro- and antioxidant properties and inhibition of 5-lipoxygenase. Planta Med. 1994;60(5):421–4.

    Article  CAS  PubMed  Google Scholar 

  21. Misik V, Bezakova L, Malekova L, Kostalova D. Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium. Planta Med. 1995;61(4):372–3.

    Article  CAS  PubMed  Google Scholar 

  22. Lee CJ, Chen LG, Liang WL, Wang CC. Multiple activities of Punica granatum linne against acne vulgaris. Int J Mol Sci. 2017;18(1):141.

    Article  PubMed Central  CAS  Google Scholar 

  23. Tsai TH, Chuang LT, Lien TJ, Liing YR, Chen WY, Tsai PJ. Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. J Med Food. 2013;16(4):324–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Peng CH, Su JD, Chyau CC, Sung TY, Ho SS, Peng CC, et al. Supercritical fluid extracts of rosemary leaves exhibit potent anti-inflammation and anti-tumor effects. Biosci Biotechnol Biochem. 2007;71(9):2223–32.

    Article  CAS  PubMed  Google Scholar 

  25. Baumann LS. Less-known botanical cosmeceuticals. Dermatol Ther. 2007;20(5):330–42.

    Article  PubMed  Google Scholar 

  26. Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep. 2007;17(6):1525–31.

    PubMed  Google Scholar 

  27. Council of Europe. Natural sources of flavourings. Report No 3, 2008. Available from: https://book.coe.int/en/health-protection-of-the-consumer/4006-natural-sources-of-flavourings-report-no-3.html.

  28. Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K. Moisturizers for acne: what are their constituents? J Clin Aesthet Dermatol. 2014;7(5):36–44.

    PubMed  PubMed Central  Google Scholar 

  29. Sheibani V, Afarinesh M, Hajializadeh Z, Abbasnejad M, Haghpanah T, Arabnezhad R, et al. Evaluation of Origanum vulgare L. ssp. viridis leaves extract effect on discrimination learning and ltp induction in the ca1 region of the rat hippocampus. Iran J Basic Med Sci. 2011;14(2):177–84.

    Google Scholar 

  30. Yang R, Shetty K. Stimulation of Rosmarinic acid in shoot cultures of oregano (Origanum vulgare) clonal line in response to proline, proline analogue, and proline precursors. J Agric Food Chem. 1998;46(7):2888–93.

    Article  CAS  Google Scholar 

  31. Lambert RJ, Skandamis PN, Coote PJ, Nychas GJ. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol. 2001;91(3):453–62.

    Article  CAS  PubMed  Google Scholar 

  32. Coccimiglio J, Alipour M, Jiang ZH, Gottardo C, Suntres Z. Antioxidant, antibacterial, and cytotoxic activities of the ethanolic Origanum vulgare extract and its major constituents. Oxidative Med Cell Longev. 2016;2016:1404505.

    Article  CAS  Google Scholar 

  33. Colantonio S, Rivers JK. Botanicals with dermatologic properties derived from first nations healing: part 2-plants and algae. J Cutan Med Surg. 2017;21(4):299–307.

    Article  PubMed  Google Scholar 

  34. Shahriari S, Yasa N, Mohammadirad A, Khorasani R, Abdollahi M. In vivo antioxidant potentials of Rosa damascene petal extract from Guilan, Iran, comparable to alpha-tocopherol. Int J Pharmacol. 2007;3(2):187–90.

    Article  Google Scholar 

  35. Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Res. 2010;9(2):163–8.

    PubMed  PubMed Central  Google Scholar 

  36. Jimenez S, Gascon S, Luquin A, Laguna M, Ancin-Azpilicueta C, Rodriguez-Yoldi MJ. Rosa canina extracts have antiproliferative and antioxidant effects on Caco-2 human colon cancer. PLoS One. 2016;11(7):e0159136.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Andersson SC, Olsson ME, Gustavsson KE, Johansson E, Rumpunen K. Tocopherols in rose hips (Rosa spp.) during ripening. J Sci Food Agric. 2012;92(10):2116–21.

    Article  CAS  PubMed  Google Scholar 

  38. Kurokawa I, Oiso N, Kawada A. Adjuvant alternative treatment with chemical peeling and subsequent iontophoresis for postinflammatory hyperpigmentation, erosion with inflamed red papules and non-inflamed atrophic scars in acne vulgaris. J Dermatol. 2017;44(4):401–5.

    Article  CAS  PubMed  Google Scholar 

  39. Burgess C. Topical vitamins. J Drugs Dermatol. 2008;7(7 Suppl):s2–6.

    PubMed  Google Scholar 

  40. Bellei E, Rota C, Bergamini S, Manfredini P, Albertazzi A, Tomasi A, et al. Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes. J Biochem Mol Toxicol. 2004;18(2):107–14.

    Article  CAS  PubMed  Google Scholar 

  41. Marmol I, Sanchez-de-Diego C, Jimenez-Moreno N, Ancin-Azpilicueta C, Rodriguez-Yoldi MJ. Therapeutic applications of rose hips from different rosa species. Int J Mol Sci. 2017;18(6):1137.

    Article  PubMed Central  CAS  Google Scholar 

  42. Kim SS, Baik JS, Oh TH, Yoon WJ, Lee NH, Hyun CG. Biological activities of Korean citrus obovoides and citrus natsudaidai essential oils against acne-inducing bacteria. Biosci Biotechnol Biochem. 2008;72(10):2507–13.

    Article  CAS  PubMed  Google Scholar 

  43. Zu Y, Yu H, Liang L, Fu Y, Efferth T, Liu X, et al. Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells. Molecules. 2010;15(5):3200–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Baik JS, Kim SS, Lee JA, Oh TH, Kim JY, Lee NH, et al. Chemical composition and biological activities of essential oils extracted from Korean endemic citrus species. J Microbiol Biotechnol. 2008;18(1):74–9.

    CAS  PubMed  Google Scholar 

  45. Naganuma M, Hirose S, Nakayama Y, Nakajima K, Someya T. A study of the phototoxicity of lemon oil. Arch Dermatol Res. 1985;278(1):31–6.

    Article  CAS  PubMed  Google Scholar 

  46. Yoon WJ, Kim SS, Oh TH, Lee NH, Hyun CG. Abies koreana essential oil inhibits drug-resistant skin pathogen growth and LPS-induced inflammatory effects of murine macrophage. Lipids. 2009;44(5):471–6.

    Article  CAS  PubMed  Google Scholar 

  47. Sayorwan W, Siripornpanich V, Piriyapunyaporn T, Hongratanaworakit T, Kotchabhakdi N, Ruangrungsi N. The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity. J Med Assoc Thail. 2012;95(4):598–606.

    Google Scholar 

  48. Essential Science Publishing. Essential oils desk reference. Orem: Essential Science Publishing; 2014.

    Google Scholar 

  49. Weckesser S, Engel K, Simon-Haarhaus B, Wittmer A, Pelz K, Schempp C. Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. Phytomedicine. 2007;14(7–8):508–16.

    Article  CAS  PubMed  Google Scholar 

  50. Man A, Santacroce L, Jacob R, Mare A, Man L. Antimicrobial activity of six essential oils against a group of human pathogens: a comparative study. Pathogens. 2019;8(1):15.

    Article  CAS  PubMed Central  Google Scholar 

  51. Sadhasivam S, Palanivel S, Ghosh S. Synergistic antimicrobial activity of Boswellia serrata Roxb. ex Colebr.(Burseraceae) essential oil with various azoles against pathogens associated with skin, scalp and nail infections. Lett Appl Microbiol. 2016;63(6):495–501.

    Article  CAS  PubMed  Google Scholar 

  52. Charousaei F, Dabirian A, Mojab F. Using chamomile solution or a 1% topical hydrocortisone ointment in the management of peristomal skin lesions in colostomy patients: results of a controlled clinical study. Ostomy Wound Manage. 2011;57(5):28.

    PubMed  Google Scholar 

  53. Sienkiewicz M, Głowacka A, Poznańska-Kurowska K, Kaszuba A, Urbaniak A, Kowalczyk E. The effect of clary sage oil on staphylococci responsible for wound infections. Postepy Dermatol Alergol. 2015;32(1):21–6.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Mori H-M, Kawanami H, Kawahata H, Aoki M. Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model. BMC Complement Altern Med. 2016;16(1):144.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  55. Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis to lavender: a retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37–42.

    Article  PubMed  Google Scholar 

  56. Tan LTH, Lee LH, Yin WF, Chan CK, Abdul Kadir H, Chan KG, et al. Traditional uses, phytochemistry, and bioactivities of Cananga odorata (Ylang-Ylang). Evid Based Complement Alternat Med. 2015;2015:896314.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Filipowicz N, Kamiński M, Kurlenda J, Asztemborska M, Ochocka JR. Antibacterial and antifungal activity of juniper berry oil and its selected components. Phytother Res. 2003;17(3):227–31.

    Article  CAS  PubMed  Google Scholar 

  58. Chimnoi N, Reuk-ngam N, Chuysinuan P, Khlaychan P, Khunnawutmanotham N, Chokchaichamnankit D, et al. Characterization of essential oil from Ocimum gratissimum leaves: antibacterial and mode of action against selected gastroenteritis pathogens. Microb Pathog. 2018;118:290–300.

    Article  CAS  PubMed  Google Scholar 

  59. Orafidiya L, Agbani E, Oyedele A, Babalola O, Onayemi O. Preliminary clinical tests on topical preparations of Ocimum gratissimum Linn leaf essential oil for the treatment of acne vulgaris. Clin Drug Investig. 2002;22(5):313–9.

    Article  CAS  Google Scholar 

  60. Orafidiya L, Agbani E, Oyedele A, Babalola O, Onayemi O, Aiyedun F. The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf–a preliminary clinical investigation. Int J Aromather. 2004;14(1):15–21.

    Article  CAS  Google Scholar 

  61. Viyoch J, Pisutthanan N, Faikreua A, Nupangta K, Wangtorpol K, Ngokkuen J. Evaluation of in vitro antimicrobial activity of Thai basil oils and their micro-emulsion formulas against Propionibacterium acnes. Int J Cosmet Sci. 2006;28(2):125–33.

    Article  CAS  PubMed  Google Scholar 

  62. Elias PM, Brown BE, Ziboh VA. The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function. J Invest Dermatol. 1980;74(4):230–3.

    Article  CAS  PubMed  Google Scholar 

  63. Vaughn AR, Clark AK, Sivamani RK, Shi VY. Natural oils for skin-barrier repair: ancient compounds now backed by modern science. Am J Clin Dermatol. 2018;19(1):103–17.

    Article  PubMed  Google Scholar 

  64. Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci. 2017;19(1):70.

    Article  PubMed Central  CAS  Google Scholar 

  65. Pazyar N, Yaghoobi R, Ghassemi MR, Kazerouni A, Rafeie E, Jamshydian N. Jojoba in dermatology: a succinct review. G Ital Dermatol Venereol. 2013;148(6):687–91.

    CAS  PubMed  Google Scholar 

  66. Nasr M, Abdel-Hamid S, Moftah NH, Fadel M, Alyoussef AA. Jojoba oil soft colloidal nanocarrier of a synthetic retinoid: preparation, characterization and clinical efficacy in psoriatic patients. Curr Drug Deliv. 2017;14(3):426–32.

    Article  CAS  PubMed  Google Scholar 

  67. Kim S, Jang JE, Kim J, Lee YI, Lee DW, Song SY, et al. Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin. Food Chem Toxicol. 2017;106(Pt A):367–75.

    Article  CAS  PubMed  Google Scholar 

  68. Strunk T, Pupala S, Hibbert J, Doherty D, Patole S. Topical coconut oil in very preterm infants: an open-label randomised controlled trial. Neonatology. 2018;113(2):146–51.

    Article  PubMed  Google Scholar 

  69. Preuss HG, Echard B, Enig M, Brook I, Elliott TB. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Mol Cell Biochem. 2005;272(1–2):29–34.

    Article  CAS  PubMed  Google Scholar 

  70. Dar AA, Arumugam N. Lignans of sesame: purification methods, biological activities and biosynthesis – a review. Bioorg Chem. 2013;50:1–10.

    Article  CAS  PubMed  Google Scholar 

  71. Chiang JP, Hsu DZ, Tsai JC, Sheu HM, Liu MY. Effects of topical sesame oil on oxidative stress in rats. Altern Ther Health Med. 2005;11(6):40–5.

    PubMed  Google Scholar 

  72. Korac RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev. 2011;5(10):164–73.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Nelson K, Lyles JT, Li T, Saitta A, Addie-Noye E, Tyler P, et al. Anti-acne activity of Italian medicinal plants used for skin infection. Front Pharmacol. 2016;7:425.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 2012;19(5):409–12.

    Article  CAS  PubMed  Google Scholar 

  75. Campisano A, Ometto L, Compant S, Pancher M, Antonielli L, Yousaf S, et al. Interkingdom transfer of the acne-causing agent, Propionibacterium acnes, from human to grapevine. Mol Biol Evol. 2014;31(5):1059–65.

    Article  CAS  PubMed  Google Scholar 

  76. Sultana Y, Kohli K, Athar M, Khar RK, Aqil M. Effect of pre-treatment of almond oil on ultraviolet B-induced cutaneous photoaging in mice. J Cosmet Dermatol. 2007;6(1):14–9.

    Article  PubMed  Google Scholar 

  77. Danby SG, AlEnezi T, Sultan A, Lavender T, Chittock J, Brown K, et al. Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care. Pediatr Dermatol. 2013;30(1):42–50.

    Article  PubMed  Google Scholar 

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Kreidel, M.K., Jhaveri, M. (2021). Introduction to Essential Oils and Essential Oil Processing. In: Rupani, R.N., Lio, P.A. (eds) Integrative Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-58954-7_5

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