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Microbiological Etiology of Necrotizing Soft Tissue Infections

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Necrotizing Soft Tissue Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1294))

Abstract

Necrotizing soft tissue infections (NSTIs) are severe clinical conditions requiring swift therapeutic intervention, including surgical removal of infected tissue and administration of potent antibiotics. There is wide diversity in the microbial etiologic agents, and tailoring the antibiotic treatment to the offending pathogen is essential. However, the choice of empirical therapy is frequently inadequate, underlining the need for comprehensive and contemporary knowledge on causative pathogens and relevant antimicrobial resistance patterns in NSTIs. Also, studies of the pathogenic mechanisms in different NSTIs are needed, to improve handling of patients through develo** patient stratification and tailored therapies. We review the current knowledge on microbial etiology and provide detailed characterizations of the predominant pathogens.

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Acknowledgment

This work was supported by the European Union Seventh Framework Programme: (FP7/2007-2013) under the grant agreement 305340 (INFECT project), NordForsk (Project no. 90456, PerAID), the Norwegian Research Council under the frame of ERA PerMed (Project 2018-151, PerMIT) and The Swedish Research Council Framework Grant in infections and antibiotics (2014-8609-117204-47).

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Authors and Affiliations

  1. Department of Clinical Science, University of Bergen, Bergen, Norway

    Steinar Skrede & Trond Bruun

  2. Department of Medicine, Haukeland University Hospital, Bergen, Norway

    Steinar Skrede, Trond Bruun, Eivind Rath & Oddvar Oppegaard

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  1. Steinar Skrede
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Correspondence to Steinar Skrede .

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  1. Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge, Sweden

    Anna Norrby-Teglund

  2. Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge, Sweden

    Mattias Svensson

  3. Department of Clinical Science, University of Bergen, Bergen, Norway

    Steinar Skrede

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Skrede, S., Bruun, T., Rath, E., Oppegaard, O. (2020). Microbiological Etiology of Necrotizing Soft Tissue Infections. In: Norrby-Teglund, A., Svensson, M., Skrede, S. (eds) Necrotizing Soft Tissue Infections. Advances in Experimental Medicine and Biology, vol 1294. Springer, Cham. https://doi.org/10.1007/978-3-030-57616-5_5

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