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Electrochemical DNA Sensors Based on Nanostructured Polymeric Materials for Determination of Antitumor Drugs

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Macro, Micro, and Nano-Biosensors

Abstract

In this chapter, recent achievements in the development of electrochemical DNA sensors intended for the determination of antitumor drugs have been presented with particular emphasis to the mechanism of signal generation and factors influencing the response of the biosensor toward anthracycline drugs. Besides, the redox properties of electrochemically active polymers as a platform for DNA immobilization and signal generation have been considered and the protocols for voltametric and impedimetric signal recording provided. The possibility to use DNA sensor described for the assessment of commercial medications and biological fluids is discussed together with the prospects of enhancement of the polymers applied in the biosensor assembly.

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Abbreviations

DNA:

Deoxyribonucleic acid

DC:

Direct current

EDOT:

Ethylenedioxythiophene

EDTA:

Ethylenediaminetetraacetic acid

EIS:

Electrochemical impedance spectroscopy

EQCM:

Electrochemical quartz crystal microbalance

LOD:

Limit of detection

PANI:

Polyaniline

PEDOT:

Poly(ethylenedioxythiophene)

PSA:

Potentiometric strip** amperometry

RNA:

Ribonucleic acid

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Acknowledgments

GE acknowledges financial support of Russian Foundation for Basic Research (RFBR), grant no. 20-03-00207. TH acknowledges the financial support of Scientific Grant Agency VEGA, project no. 1/0419/20.

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Authors and Affiliations

  1. Analytical Chemistry Department, Kazan Federal University, Kazan, Russia

    Anna Porfireva & Gennady Evtugyn

  2. Department of Nuclear Physics and Biophysics, Comenius University, Bratislava, Slovakia

    Tibor Hianik

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  1. Anna Porfireva
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  2. Tibor Hianik
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  3. Gennady Evtugyn
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Editors and Affiliations

  1. Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Laboratory of Biosensors, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms Pushchino Center for Biological Research of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia

    Anatoly Reshetilov

  3. Laboratory of Biosensors, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms Pushchino Center for Biological Research of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia

    Yulia Plekhanova

  4. Department of Biotechnology Engineering School of Lorena, University of Sao Paulo, Lorena, SP, Brazil

    Avinash P Ingle

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Porfireva, A., Hianik, T., Evtugyn, G. (2021). Electrochemical DNA Sensors Based on Nanostructured Polymeric Materials for Determination of Antitumor Drugs. In: Rai, M., Reshetilov, A., Plekhanova, Y., Ingle, A.P. (eds) Macro, Micro, and Nano-Biosensors. Springer, Cham. https://doi.org/10.1007/978-3-030-55490-3_11

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