Definition
Biorelevant dissolution media are aqueous solutions or suspensions whose composition and physicochemical characteristics closely resemble human fluids found along the different portions of the gastrointestinal tract, developed to study the solubility and/or dissolution profile of orally administered drugs in a more physiologically relevant manner.
Main Text
Oral solid dosage forms are the most widely used dosage forms due to their ease of application and patient comfort. For these pharmaceutical dosage forms, the release, but more precisely, the dissolution characteristics are critical factors to ensure the in vivo performance of the pharmaceutical active ingredients: to be absorbed, drug must be dissolved under the physiological conditions that surround the absorption site at the gastrointestinal (GI) tract. Therefore, in vitro dissolution test has become a...
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Ruiz, M.E., Talevi, A. (2021). Biorelevant Dissolution Media. In: The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-51519-5_43-1
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DOI: https://doi.org/10.1007/978-3-030-51519-5_43-1
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