Abstract
Modern lesion-symptom map** methods offer highly sophisticated ways of identifying particular regions and networks, disruptions in which are causally associated with specific speech and language deficits. The translational insight afforded from these approaches is highly promising for improved patient care. This chapter briefly describes the history of and the major advances in the field, highlights the translational possibilities of advanced lesion-symptom map**, and identifies challenges and future directions for these endeavors.
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Abbreviations
- CT:
-
Computed tomography
- fMRI:
-
Functional magnetic resonance imaging
- LSM:
-
Lesion-symptom map**
- MRI:
-
Magnetic resonance imaging
- NPM:
-
Non-parametric map**
- PLORAS:
-
Predict language outcome and recovery after stroke
- tDCS:
-
Transcranial direct current stimulation
- TMS:
-
Transcranial magnetic stimulation
- VLBM:
-
Voxel-based lesion-behavior map**
- VLSM:
-
Voxel-based lesion-symptom map**
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Further Reading
Baldo, J. V., Wilson, S. M., & Dronkers, N. F. (2012). Uncovering the neural substrates of language: A voxel-based lesion–symptom map** approach. The Handbook of the Neuropsychology of Language, 2, 582-594.
Bates, E., Wilson, S. M., Saygin, A. P., Dick, F., Sereno, M. I., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom map**. Nature Neuroscience, 6, 448–450.
Price, C. J., Hope, T. M., & Seghier, M. L. (2017). Ten problems and solutions when predicting individual outcome from lesion site after stroke. Neuroimage, 145, 200–208.
Price, C. J., Seghier, M. L., & Leff, A. P. (2010). Predicting language outcome and recovery after stroke: the PLORAS system. Nature Reviews Neurology, 6, 202–210.
Pustina, D., Avants, B., Faseyitan, O. K., Medaglia, J. D., & Coslett, H. B. (2018). Improved accuracy of lesion to symptom map** with multivariate sparse canonical correlations. Neuropsychologia, 115, 154–166.
Rorden, C., Karnath, H.-O., & Bonilha, L. (2007). Improving lesion-symptom map**. Journal of Cognitive Neuroscience, 19, 1081–1088.
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Argyropoulos, G.P.D. (2020). Lesion-Symptom Map** in Speech and Language Disorders: A Translational Perspective. In: Argyropoulos, G.P.D. (eds) Translational Neuroscience of Speech and Language Disorders. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-030-35687-3_11
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