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Infection and Endometrial Gene Expression: HHV-6 and Infertility

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Endometrial Gene Expression

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Abstract

Pathogens represent a tremendous burden on the reproductive fitness of humans, tailoring variations in endometrial immune cells. As such, the immune phenotypes of endometrial immune cells can have a profound effect on how an infectious pathogen might reduce the reproductive fitness of individuals in a population. HHV-6 is a betaherpesvirus that exists as two closely related variants, HHV-6A and HHV-6B. Recently, HHV-6 infection of the female genital tract has been implicated in pregnancy-related diseases. In particular, the presence of HHV-6 infection of the endometrial epithelial cells seems to be associated with female idiopathic infertility, causing a specific modification of gene expression in both endometrium and endometrial natural killer cells.

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  1. University of Ferrara, Department of Chemical and Pharmaceutical Sciences, Ferrara, Italy

    Roberta Rizzo

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  1. Reproductive Medicine and Immunology Clinical Sciences, Obstetrics and Gynecology, Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA

    Joanne Kwak-Kim

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Rizzo, R. (2020). Infection and Endometrial Gene Expression: HHV-6 and Infertility. In: Kwak-Kim, J. (eds) Endometrial Gene Expression. Springer, Cham. https://doi.org/10.1007/978-3-030-28584-5_9

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