Summary
Bone and bone marrow are specimens recently investigated as a matrix for drug testing. Following extraction by soaking bone in organic solvent, routine drug assays may be utilized to measure compounds. Antidepressants, benzodiazepines, and illicit drugs such as cocaine have been reported in bone.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
McIntyre LM, King CV, Boratto M, Drummer OH. Post-mortem drug analyses in bone and bone marrow. Ther Drug Monit 2000;22(1):79–83.
Winek CL, Westwood SE, Wahba WW. Plasma versus bone marrow desipramine: a comparative study. Forensic Sci Int 1990;48(1):49–57.
McGrath KK, Jenkins AJ. Analysis of postmortem bone/bone marrow specimens for drugs of importance in forensic toxicology. In: Proceedings of the Joint TIAFT/SOFT Annual Meeting, Washington DC, 2004.
Winek CL, Costantino AG, Wahba WW, Collom WD. Blood versus bone marrow pentobarbital concentrations. Forensic Sci Int 1985;27(1):15–24.
Winek CL, Pluskota M, Wahba WW. Plasma versus bone marrow flurazepam concentration in rabbits. Forensic Sci Int 1982;19(2):155–163.
Kojima T, Okamoto I, Miyazaki T, Chikasue F, Yashiki M, Nakamura K. Detection of methamphetamine and amphetamine in a skeletonized body buried for 5 years. Forensic Sci Int 1986;31(2):93–102.
Kudo K, Sugie H, Syoui N, Kurihara K, Jitsufuchi N, Imamura T, et al. Detection of triazolam in skeletal remains buried for 4 years. Int J Legal Med 1997;110(5): 281–283.
Bosche J, Burger E. Bromide-content in bones after poisoning with sedatives of bromine content. Beitr Gerichtl Med 1974;32:185–186.
Noguchi TT, Nakamura GR, Griesemer EC. Drug analyses of skeletonizing remains. J Forensic Sci 1978;23(3):490–492.
Bal T, Hewitt R, Hiscutt A, Johnson B. Analysis of bone marrow and decomposed body tissue for the presence of paracetamol and dextropropoxyphene. J Forensic Sci Soc 1989;29:219–223.
Wohlenberg N, Lindsey T, Backer R, Nolte K. Nortriptyline in maggots, muscle, hair, skin and bone in skeletonized remains. TIAFT Bulletin 1992;22(3):19–22.
Maeda H, Oritani S, Nagai K, Tanaka T, Tanaka N. Detection of bromisovalum from the bone marrow of skeletonized human remains: a case report with a comparison between gas chromatography/mass spectrometry (GC/MS) and high-performance liquid chromatography/mass spectrometry (LC/MS). Med Sci Law 1997;37(3):248–253.
Nagata T, Kimura K, Hara K, Kudo K. Methamphetamine and amphetamine concentrations in postmortem rabbit tissues. Forensic Sci Int 1990;48(1):39–47.
Gorczynski LY, Melbye FJ. Detection of benzodiazepines in different tissues, including bone, using a quantitative ELISA assay. J Forensic Sci 2001;46(4):916–918.
Raikos N, Tsoukali H, Njau SN. Determination of opiates in postmortem bone and bone marrow. Forensic Sci Int 2001;123(2–3):140–141.
Cattaneo C, Gigli F, Lodi F, Grandi M. The detection of morphine and codeine in human teeth: an aid in the identification and study of human skeletal remains. J Forensic Odontostomatol 2003;21(1):1–5.
Pellegrini M, Casa A, Marchei E, Pacifici R, Mayne R, Barbero V, et al. Development and validation of a gas chromatography-mass spectrometry assay for opiates and cocaine in human teeth. J Pharm Biomed Anal 2005;40(3):662–668.
Horak, EL, Jenkins AJ. Postmortem tissue distribution of olanzapine and citalopram in a drug intoxication. J Forensic Sci 2005;50(3):679–681.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Humana Press
About this chapter
Cite this chapter
Drummer, O.H. (2008). Drugs in Bone and Bone Marrow. In: Jenkins, A.J., Caplan, Y.H. (eds) Drug Testing in Alternate Biological Specimens. Forensic Science And Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-318-9_8
Download citation
DOI: https://doi.org/10.1007/978-1-59745-318-9_8
Publisher Name: Humana Press
Print ISBN: 978-1-58829-709-9
Online ISBN: 978-1-59745-318-9
eBook Packages: MedicineMedicine (R0)