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Hypericum perforatum

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Medicinal Plants of the World

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Abstract

A herbaceous, rhizomatous perennial herb of the HYPERICACEAE family that grows to a height of up to 1 m with erect stems that are 2-edged and branching in the upper part. The leaves are pale green, opposite, sessile, oblong, ovate or linear, 8–24 mm long with black dots or oil glands that can be seen when holding the leaf to light. The flowers are bright yellow, about 25 mm in diameter, in terminal corymbose cymbes. The calyx and corolla are marked with black dots and lines. Sepals and petals are 5 in number, and the ovary is pear-shaped with 3 long style. The capsule is 3-celled, ovoid, 8 mm long, with many small round blackish seeds. The pland has a characteristic balsamic odor and a bitter, resinous, somewhat astringent taste.

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References

  1. Mishra, M. B., J. P. Tewari and S. K. Bapat. A preliminary pharmacological screening of Hypericum perforatum. Labdev 1965; 3: 272.

    Google Scholar 

  2. Konopa, J., E. Jereczek, A. Matuszkiewicz and T. Nazarewicz. Screening of antitumor substances from plants. Arch Immunol Ther Exp 1967; 15: 129.

    CAS  Google Scholar 

  3. Dhawan, B. N. and F. N. Saxena. Evaluation of some indigenous drugs for stimulant effect on the rat uterus. A preliminary report. Indian J Med Res 1958; 46(6): 308–311.

    Google Scholar 

  4. Rolleri, F. Occurrence of nicotinic acid and nicotinamide in curative plants. Arch Pharm (Weinheim) 1943; 281: 118.

    Article  CAS  Google Scholar 

  5. El’Yashevych, O. H. and R. Cholii. Some means of treatment in the folk medicine of Lvov. Farm ZH (Kiev) 1972; 27(6): 78.

    Google Scholar 

  6. Fitzpatrick, F. K. Plant substances active against Mycobacterium tuberculosis. Antibiot Chemother 1954; 4:528.

    CAS  Google Scholar 

  7. Saha, J. C., E. C. Savini and S. Kasinathan. Ecbolic properties of Indian medicinal plants. Part Indian J Med Res 1961; 49: 130–151.

    CAS  Google Scholar 

  8. Broda, B. and E. Andrzejewska. Choline content in some medicinal plants. Farm Pol 1966; 22: 181–184.

    CAS  Google Scholar 

  9. Isaev, V. Essential oils of the flora of Tadshikistan. Acta Hortii Bot Tadshikistan 1932; 1932: 17.

    Google Scholar 

  10. Lawrendiadis, G. Contribution to the knowledge of the medicinal plants of Greece. Planta Med 1961; 9: 164.

    Article  CAS  Google Scholar 

  11. Jerzmanowska, Z. Hyperin, a glucoside of Hypericum perforatum. Wiadomosci Farm 1937; 64: 527.

    CAS  Google Scholar 

  12. Makoru, L. Hair restorer. Patent Austrian-176,950 1953.

    Google Scholar 

  13. Roth, L. Hypericin content of various varieties of Hypericum perforatum. Dtsch Apoth Ztg 1953; 63: 653.

    Google Scholar 

  14. Gurevich, A. I., V. N. Dobrynin, M. N. Kolosov, S. A. Popravko, I. D. Ryabova, B. K. Chernov, N. A. Derbentseva, B. E. Aizenman and A. D. Garagulya. Hyperforin, an antibiotic from Hypericum perforatum. Antibiotiki (Moscow) 1971; 16: 510.

    CAS  Google Scholar 

  15. Maksyutina, N. P. and D. G. Kolesnikov. Extraction of hyperin and quercetin from Hypericum perforatum. Med Prom SSR 1964; 18(3): 41.

    CAS  Google Scholar 

  16. Biochinov, A., D. Drumev, R. Gakhniyan and K. Akhtardzhiev. Bioflavonoid from Hypericum perforatum possessing Vitamin P activity. Farmatsiya (Sofia) 1965; 15(2): 92.

    Google Scholar 

  17. Khalmatov, K. K. Quantitative changes in tannin substances and in ascorbic acid in plants. Dokl Akad Nauk Uzb SSR 1957; 14(3): 35.

    Google Scholar 

  18. Daniels, F. A simple microbiological method for demonstrating phototoxic compounds. J Invest Dermatol 1965; 44: 259.

    CAS  Google Scholar 

  19. Burrall, F. A. Some uses of the Oleum hyperici. N Engl Med Monthly 1887; 7: 342.

    Google Scholar 

  20. Seddon, H. R. and H. G. Belschner. The effect of young immature St. John’s Wort on sheep. Agr Gaz N S W 1929; 40(12): 914.

    Google Scholar 

  21. Gress, E. M. Poisonous plants of Pennsylvania. Penn Dept Agr Bull 1935; 531 18(5): 1.

    Google Scholar 

  22. Derbentseva, N. A., A. S. Rabinovich and S. I. Zelepukha. Novio-manin, an antiotic preparation from Hypericum perforatum. Dopov Akad Nauk Ukr Rsr 1963; 1963 (9): 1248.

    Google Scholar 

  23. Chaplinskaya, M. G. The composition of Hypericum perforatun grass. Sbornik 1956; 1956: 269.

    Google Scholar 

  24. Vander, A. Plantas Medicinales Editorial Sintes, Barcelona-7, 1972.

    Google Scholar 

  25. Anon. Lilly’s Handbook of Pharmacy and Therapeutics. 5th Rev, Eli Lilly and Co, Indianapolis, 1898.

    Google Scholar 

  26. Neuwald, F. and U. Hagenstrom. The estimation of tannins in Hypericum perforatum. Sci Pharm 1953; 21: 242.

    Google Scholar 

  27. Grims, M. Flavonoids of Hypericum perforatum and some other Hypericum species. Acta Pharm Jugosl 1959; 9: 113.

    CAS  Google Scholar 

  28. Zaitseva, I. M. The effect of common St. John’s Wort on the gastrointestinal tract. Zdravookhr Beloruss 1966: 12(5): 23.

    Google Scholar 

  29. Cunningham, I. J. Photosensitivity diseases in New Zealand v. photosensitization by St. John’s Wort (Hypericum perforatum). N Z J Sci Technol 1947; 29A: 207.

    Google Scholar 

  30. Fedorchuk, A. M. Effect of Hypericum perforatum on experimentally infected wounds. Mikrobiol Zh (Kiev) 1964; 26: 32.

    CAS  Google Scholar 

  31. Borkowski, B., A. Duchnowska and T. Wrocinski. Flavonoid content of Hypericum perfora-tumn. Biul Inst Rosl Leczn 1959; 5: 227.

    CAS  Google Scholar 

  32. Aizenman, B. Y. Antibiotic preparations from St. John’s Wort (Hypericum perforatum). Mikrobiol Zh (Kiev) 1969; 31(2): 128.

    CAS  Google Scholar 

  33. Mathis, C. and G. Ourisson. Chemotaxonomic study of the genus Hypericum. V. Identification of several non-volatile constituents of Hypericum perforatum L. Phytochemistry 1964; 3(3): 379.

    Article  CAS  Google Scholar 

  34. Mathis C. and G. Ourisson. Chemotaxonomic study of the genus Hypericum. IV. Distribution of sesquiterpenes, monoterpene alcohols and saturated alehydes from the essential oil of Hypericum. Phytochemistry 1964; 3(3): 377–378.

    Article  CAS  Google Scholar 

  35. Mathis C. and G. Ourisson. Chemo-taxonomic study of the genus Hypericum. III. The distribution of saturated hydrocarbons and monoterpenes from the essential oil of Hypericum. Phytochemistry 1964; 3(1): 133–141.

    Article  CAS  Google Scholar 

  36. Costes, C. Carotenoid pigments in the flowers and petals of Hypericum perforatum. Ann Physiol Veg 1967 9(2): 157–177.

    CAS  Google Scholar 

  37. Maisenbacher, P. and K. A. Kovar. Adhyperforin: A homologue of hyperforin from Hypericum perforatum. Planta Med 1992 58(3) 291–293

    Article  CAS  Google Scholar 

  38. Rucker, G., D. Manns, R. Hartmann and U. Bonsels. Peroxides as constituents of plants, Part 19. A C50-hydroperoxide from Hypericum perforatum. Acta Pharm Nordica 1995; 328(10): 725–730.

    Google Scholar 

  39. Weyerstahl, P., U. Splittgerber, H. Marschall and V. K. Kaul. Constituents of the leaf essential oil of Hypericum perforatum L. from India. Flavour Fragrance J 1995; 10(6): 365–370.

    Article  CAS  Google Scholar 

  40. Rucker, G., D. Manns, R. Hartmann and U. Bonsels. A C50-Hydroperoxide from Hypericum perforatum. Arch Pharm (Weinheim) 1995; 328(10): 725–730.

    Article  Google Scholar 

  41. Saljic, J. Ointment for the treatment of burns. Patent-Ger Offen 2,406,452–1975.

    Google Scholar 

  42. Wheatley, D., E. U. Vorbach, B. Mockel and J. Beuth. Evidence for benefit of St. John’s Wort in depressive disorders. Pharmaceutical J 1996; 257(6919): 770–771.

    Google Scholar 

  43. Wincor, M. Z. and M. A. Gutierrez. St. John’s Wort and the treat-ment of depression. US Pharmacist 1997: 22(8): 88–97.

    Google Scholar 

  44. Araya, O. S. and E. J. H. Ford. An investigation of the type of photosensitization caused by the ingestion of St. John’s Wort (Hypericum perforatum) by calves. J Comp Path 1981; 91: 135–141.

    Article  CAS  Google Scholar 

  45. Melzer, R., U. Fricke, R. Podehl and J. Zylka. Procyanidins from Hypericum perforatum: Effects on isolated guinea pig hearts. Planta Med 1989; 55: 655–656.

    Article  Google Scholar 

  46. Stock, S. and J. Holzl. Pharmacokinetic test of (14-C)-labelled hypericin and pseudohypericin from Hypericum perforatum and serum kinetics of hypericin in man. Planta Med Suppl 1991; 57(2): A61–A62.

    Article  Google Scholar 

  47. Okpanyi, V. S. N. and M. L. Weischer. Experimental animal studies of the psychotropic activity of a Hypericum extract. Arzneim-Forsch 1987; 37(1): 10–13.

    CAS  Google Scholar 

  48. Brondz, I., T. Greibrokk, P. A. Groth, and J. Aasen. The relative stereochemistry of hyperforin — an antibiotic from Hypericum perforatum L. Tetrahedron Lett 1982; 23(12): 1299–1300.

    Article  CAS  Google Scholar 

  49. Melzer, R., U. Fricke and J. Holzl. Vasoactive properties of procyandins from Hypericum perforatum L. in isolated porcine coronary arteries. Arzneim-Forsch 1991; 41(1): 481–483.

    CAS  Google Scholar 

  50. Girzu, M., A. Carnat, A. M. Provat, J. Fialip, A. P. Carnat and J. L. Lamaison. Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L. Phytother Res 1997; 11(5): 395– 397.

    Article  Google Scholar 

  51. Perovic, S. and W. E. G. Miller. Pharmacological profile of Hypericum extract. Effect on serotonin uptake by postsynaptic receptors. Arzneim-Forsch 1995; 45(11): 1145–1148.

    CAS  Google Scholar 

  52. De Smet, P. A. G. M. and W. A. Nolen. St. John’s Wort as an antidepressant: Longer term studies are needed before it can be recommended in major depression. Brit Med J 1996; 313(7052): 241–242.

    Article  Google Scholar 

  53. Brantner, A., T. Kartnig and F. Quehenberger. Comparative phytochemical investigation of Hypericum perforatum L. and Hypericum maculatum Crantz. Sci Pharm 1994; 62: 261–276.

    CAS  Google Scholar 

  54. Grauds, C. St. John’s Wort for depression. Pharmacy Times 1997; 63(10): 40.

    Google Scholar 

  55. Woelk, H., G. Burkard and J. Grunwald. Benefits and risk of the Hypericum extract LI 160: Drug monitoring study with 3250 patients. J Geriat Psychiat Neurol 1994; 7: 834–838.

    Google Scholar 

  56. Prokosheva, L. I. and L. V. Shatunova. Content of active substances in the aboveground parts of Hypericum perforatum. Rast Resur 1985; 21(4): 461–463.

    CAS  Google Scholar 

  57. Carey, B. The sunshine supplement. Can a humble herb really chase your blues away? Health 1998; 12(1): 53–55.

    Google Scholar 

  58. Dittman, V. J., H. D. Herrmann and H. Palleske. Normalizing glucose metabolism in brain tumor slices by hyperoside. ArzneimForsch 1971; 21(12): 1999–2002.

    Google Scholar 

  59. Cot, J. Natural product formulations available in Europe for psychotropic indications. Psychopharmacol Bull 1995; 31(4): 745–751.

    Google Scholar 

  60. Hubner, W. D., S. Lande and H. Podzuweit. Hypericum treatment of mild depressions with somatic symptoms. J Geriat Psychiat Neurol 1994 7(1) S12–S14

    Article  Google Scholar 

  61. Vorbach, E. U., W. D. Hubner and K. H. Arnoldt. Effectiveness and tolerance of the Hypericum extract LI 160 in comparison with imipramine: Randomized double-blind study with 135 outpatients. J Geriat Psychiat Neurol 1994; 7(1): S19–S23.

    Article  Google Scholar 

  62. Sommer, H. and G. Harrer. Placebo-controlled double-blind study examining the effectiveness of an Hypericum preparation in 105 mildly depressed patients. J Geriat Psychiat Neurol 1994; 7(1): S9–S11.

    Article  Google Scholar 

  63. Holzl, J. and E. Ostrowski. HPLC analysis of the constituents and the variety in populations. Dtsch Apoth Ztg 1987; 127(23): 1227–1230.

    Google Scholar 

  64. Wagner, H. and S. Bladt. Pharmaceutical quality of Hypericum extracts. J Geriat Psychiat Neurol 1994; 7(81): 865–868.

    Google Scholar 

  65. Klaus, L., G. Ramirez, C. D. Muldrow, A. J. Pauls, W. G. Weidenhammer and D. Melchart. St. John’s Wort for depression-An overview and metaanalysis of randomised clinical trials. Brit Med J 1996; 313(7052): 253–258.

    Article  Google Scholar 

  66. Demisch, L., J. Holzl, B. Gollnik and P. Kaczmarczyk. Identification of selective MAO-type-A inhibitors in Hypericum perforatum L. (Hyperforat). Pharmacopsychiatry 1989; 22: 194.

    Google Scholar 

  67. Thiele, B., I. Brink and M. Ploch. Modulation of cytokine expression by Hypericum extract. J Geriat Psychiat Neurol 1994; 7(1): S60–S62.

    Article  Google Scholar 

  68. Mueller, W. E. and C. Schaefer. St. John’s Wort. In vitro investigation on Hypericum extract, hypericin, and kaempferol as antidepressant. Dtsch Apoth Ztg 1996; 136(3): 17–22.

    CAS  Google Scholar 

  69. Falk, H. and W. Schmitzberger. On the nature of “soluble” hypericin in Hypericum species. Monatsh Chem 1992; 123(8/9): 731–739.

    Article  CAS  Google Scholar 

  70. Kartnig, T. and B. Heydel. Effects of visible and ultraviolet light on the production of hypericins and flavonoids in cell cultures of Hypericum perforatum. Planta Med Suppl 1993; 59(7): A654.

    Article  Google Scholar 

  71. Thiede, H. M. and A. Walper. Inhibition of MAO and COMT by Hypericum extracts and hypericin. J Geriat Psychiat Neurol 1994; 7(Suppl): 854–856.

    Google Scholar 

  72. Hansgen, K. D., J. Vesper and M. Ploch. Multicentre double blind study examining the antidepressant effectiveness of the Hypericum extract LI 160. Nervenheilkunde 1993; 12: 285–289.

    Google Scholar 

  73. Murch, S. J., C. B. Simmons and P. K. Saxena. Melatonin in feverfew and other medicinal plants. Lancet 1997; 350(9091): 1598–1599.

    Article  CAS  Google Scholar 

  74. Girzu, M., A. P. Carnat and J. L. Chabard. Fatty acid composition of the Hypericum perforatum flowering tops. Li Corps Gras Lipides 1995; 2(4): 317–318.

    CAS  Google Scholar 

  75. Mueck-Weymann, M., K. Tritt, T. Moesler, T. Rechlin and P. Joraschky. Does St. John’s Wort have an effect on autonomic responses of cutaneous circulation? Microvasc Res 1997; 54(3): 270–272.

    Article  CAS  Google Scholar 

  76. Schulz, V., W. D. Hubner and M. Ploch. Clinical trials with phyto-psychopharmacological agents. Phytomedicine 1997; 4(4): 379–387.

    Article  CAS  Google Scholar 

  77. Baureithel, K. H., K. B. Buter, A. Engesser, W. Burkard and W. Schannfer. Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. Pharm Acta Heiv 1997; 72(3): 153–157.

    Article  CAS  Google Scholar 

  78. Mishenkova, E. L., N. A. Derbentseva, A. D. Garagulya and L. N. Litvin. Antiviral properties of St. John’s Wort and preparations produced from it. Tr Szeda Mikrobiol Ukr 1975; 4th 1975: 222.

    Google Scholar 

  79. Link, R. P. Toxic plants, rodenticides, herbicides and yellow fat disease. Diseases of Swine Dunne H. W.: Lemon Ad (EDS) Iowa State Univ Press, Ames, Iowa 4th Ed, 1975; 861.

    Google Scholar 

  80. Maisenbacher, P. and K. A. Kovar. Analysis and stability of Hyperici oleum. Planta Med 1992; 58(4): 351–354.

    Article  CAS  Google Scholar 

  81. Haeberlin, H., K. P. Tschiersch, S. Stock and J. Hoelzl. St. John’s Wort (Hyperteum perforatum L.). Part I. Identification of an additional naphthodianthrone. Pz Wiss 1992; 5(4): 169–174.

    Google Scholar 

  82. Seabra, R. M., M. H. Vasconcelos, M. A. C. Costa and A. C. Alves. Phenolic compounds from Hypericum perforatum and H. undulatum. Fitoterapia 1992; 63(5): 473–474.

    CAS  Google Scholar 

  83. McCutcheon, A. R., S. M. Ellis, R. E. W. Hancock and G. H. N. Towers. Antibiotic screening of medicinal plants of the British Columbian native peoples. J Ethnopharmacol 1992; 37(3): 213–223.

    Article  CAS  Google Scholar 

  84. Sparenberg, B., L. Demisch and J. Hoelzl. Antidepressive constituents of St. John’s Wort. Pz Wiss 1993; 6(2): 50–54.

    CAS  Google Scholar 

  85. Sezik, E., M. Zor and E. Yesilada. Traditional medicine in Turkey II. Folk medicine in Kastamonu. Int J Pharmacog 1992; 30(3): 233–239.

    Article  Google Scholar 

  86. Falk, H. and W. G. Schmitzberger. On the nature of “soluble” hypericin in Hypericum species. Monatsh Chem 1992; 123(8/9): 731–739.

    Article  CAS  Google Scholar 

  87. Malamas, M and M. Marselos. The tradition of medicinal plants in Zagori, Epirus (Northwestern Greece). J Ethnopharmacol 1992; 37(3): 197–203.

    Article  CAS  Google Scholar 

  88. Schimmer, O., A. Kruger, H. Paulini and F. Haefele. An evaluation of 55 commercial plant extracts in the Ames mutagenic-ity test. Pharmazie 1994; 49(6): 448–451.

    CAS  Google Scholar 

  89. Poginsky, B., J. Westendorf, N. Prosenc, M. Kuppe and H. Marquardt. Genotoxicity due to its quercetin content. Dtsch Apoth Atg 1988; 128(26): 1364–1366.

    CAS  Google Scholar 

  90. McCutecheon, A. R., S. M. Ellis, R. E. W. Hancock, and G. H. N. Towers. Antifungal screening of medicinal plants of British Columbian native peoples. J Ethnopharmacol 1994; 44(3): 157–169.

    Article  Google Scholar 

  91. Yesilada, E., G. Honda, E. Sezik, M. Tabata, T. Fujita, T. Tanaka, Y. Takeda and Y. Takaishi. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. J Ethnopharmacol 1995; 46(3): 133–152.

    Article  CAS  Google Scholar 

  92. Harrer, G. and H. Sommer. Treatment of mild/moderate depressions with Hypericum. Phytomedicine 1994: 1(1): 3–8.

    Article  CAS  Google Scholar 

  93. Rivera D. and C. Obon. The ethnopharmacology of Madeira and Porto Santo Islands, a review. J Ethnopharmacol 1995; 46(2): 73–93.

    Article  CAS  Google Scholar 

  94. Ozturk, Y., S. Aydin, R. Beis, K. H. C. Baser and H. Berberoglu. Effects of Hypericum perforatun L. and Hypericum calycinum L. extracts on the central nervous system in mice. Phytomedicine 1996: 3(2): 139–146.

    Article  CAS  Google Scholar 

  95. Pacheco, P., J. Sierra, G. Schmeda-Hirschmann, C. W. Potter, B. M. Jones and M. Moshref. Antiviral activity of Chilean medicinal plant extracts. Phytother Res 1993; 7(6): 415–418.

    Article  Google Scholar 

  96. Kartnig, T., I. Gobel and B. Heydel. Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes. Planta Med 1996; 62 (1): 51–53.

    Article  CAS  Google Scholar 

  97. Ernst, E. St. John’s Wort in depression. Pharm J 1995; 255(6862): 491.

    Google Scholar 

  98. Heinerman, J. Medical doctors’ guide to herbs. Biworld Publishers, Provo, Utah (ISBN-0–89557–016–5), 1977.

    Google Scholar 

  99. Nielsen, H. and P. Arends. Structure of the xanthonolignoid kielcorin. Phytochemistry 1978; 17: 2040–2041.

    Article  CAS  Google Scholar 

  100. Ollivier, B., C. Balansard, C. Maillard, E. Vidal and G. Boudon. Separation and identification of phenolic acids in parietary (Parietaria officinalis L.) and Saint-John’s Wort (Hypericum perforatum L.) by HPLC and UV. J Pharm Belg 1985; 40 (3): 173–177.

    CAS  Google Scholar 

  101. Berghofer, R. and J. Holzl. Biflavonoids in Hypericum perforatum-1, part 1. Isolation of 13, II8biapigenin. Planta Med 1987; 53(2): 216–217.

    Article  CAS  Google Scholar 

  102. Grujic-Vasic, J., T. Bosnic, and M. Jovanovic. The examining of isolated tannins and their astringent effect. Planta Med 1986; 1986(6): 548–540.

    Article  Google Scholar 

  103. Schimmer, O., F. Hafele and A. Kruger. The mutagenic potencies of plant extracts containing quercetin in Salmonella typhimurium TA98 and TA 100. Mutat Res 1988; 206(2): 201–208.

    Article  CAS  Google Scholar 

  104. Mascolo, N., G. Autore, F. Capasso, A. Menghini and M. P. Fasulo. Biological screening of Italian medicinal plants for antiinflammatory activity. Phytother Res 1987; 1(1): 28–31.

    Article  Google Scholar 

  105. Poginsky, B., J. Westendorf, N. Prosenc, M. Kuppe and H. Marquardt. St. John’s Wort (Hypericum perforatum L.). Genotoxicity due to the quercetin content. Dtsch Apoth Ztg 1988; 128(26): 1346–1366.

    Google Scholar 

  106. Barbagallo, C. and G. Chisari. Antimicrobial activity of three Hypericum species. Fitoterapia 1987; 58(3): 175–177.

    Google Scholar 

  107. Akhtardzhiev, K. H., M. Koleva, G. Kitanov and S. Ninov. Pharmacognostic study of representatives of Arum, Althaea and Hypericum species. Farmatsiya (Sofia) 1984; 34(3): 1–6.

    CAS  Google Scholar 

  108. Okpanyi, S. N., H. Lidzba, B. C. Scholl and H. C. Miltenburger. Investigations into the genotoxicity of a standardized extract of Hypericum perforatum. Arzneim-Forsch 1990; 40(8): 851–855.

    CAS  Google Scholar 

  109. Ozturk, Y., S. Aydin, K. H. C. Baser, N. Kirimer and N. KurtarOzturk. Hepatoprotective activity of Hypericum perforatum L. alcoholic extract in rodents. Phytother Res 1992; 6(1): 44–46.

    Article  Google Scholar 

  110. Rao, S. C., A. L. Udupa, S. L. Udupa, P. G. M. Rao, G. Rao and D. R. Kulkarni. Calendula and Hypericum: Two homeopathic drugs promoting wound healing in rats. Fitoterapia 1991; 62(6): 508.

    Google Scholar 

  111. Newman, L. F. Ophelia’s herbal. Econ Bot 1979; 33: 227–232.

    Article  Google Scholar 

  112. Gella, E. V., L. V. Shatunova and V. A. Biryuk. Quercetin. PatentUSSR-701,640 1979.

    Google Scholar 

  113. Tucakov, J. Ethnotherapy of diabetes. Srp Arh Celok Lek 1978; 106: 159–173.

    CAS  Google Scholar 

  114. Giese, A. C. Hypericism. (Review). Photochem Photobiol Rev 1980; 5: 229–255.

    Article  CAS  Google Scholar 

  115. Jela, G. V. and B. Tamara. Study of plant oxyaromatic acids. Arh Farm 1981; 31(5/6): 273–278.

    Google Scholar 

  116. Vickery, A. R. Traditional uses and folklore of Hypericum in the British Isles. Econ Bot 1981; 35: 289–295.

    Article  Google Scholar 

  117. Khosa, R. L. and N. Bhatia. Antifungal effect of Hypericum perforatum Linn. J Sci Res Pl Med 1982; 3(2/3): 49–50.

    Google Scholar 

  118. Dornberger, K. and H. Lich. Screening for antimicrobial and presumed cancerostatic plant metabolites. Pharmazie 1982; 37 (3): 215–221.

    CAS  Google Scholar 

  119. Karryev, M. O. and N. F. Komissarenko. Phytochemical study of Hypericum L. plants of the Turkmenian flora. Izv Akad Nauk Turkm Ssr Ser Biol Nauk 1980; 1980(3): 52–57.

    Google Scholar 

  120. Razzack, H. M. A. The concept of birth control in Unani medical literature. Unpublished manuscript of the author 1980; 64 pp.

    Google Scholar 

  121. Brondz, I., T. Greibrokk and A. J. Aasen. N-1-Alkanols of Hypericum perforatum. J Nat Prod 1983; 46(6): 940.

    Article  CAS  Google Scholar 

  122. Kitanov, G. Determination of the absolute configuration of catechins isolated from Hypericum perforatum. Farmatsiya (Sofia) 1983; 33(2): 19–22.

    CAS  Google Scholar 

  123. Hooper, S. N. and R. F. Chandler. Herbal remedies of the Maritime Indians: Phytosterols and triterpenes of 67 plants. J Ethnopharmacol 1984; 10(2): 181–194.

    Article  CAS  Google Scholar 

  124. Itokawa, H. S. Mihashi, K. Watanabe, H. Natsumoto and T. Hamanaka. Studies on the constituents of crude drugs having inhibitory activity against contraction of the ileum caused by histamine or barium chloride (1). Screening test for the activity of commercially available crude drugs and the related plant materials. Shoyakugaku Zasshi 1983; 37(3): 223–228.

    Google Scholar 

  125. Hardman, J. T., M. L. Beck and C. E. Owensby. Range forb lectins. Transfusion 1983; 23(6): 519–522.

    Article  CAS  Google Scholar 

  126. Muldner, H. and M. Zoller. Antidepressive effect of a Hypericum extract standardized to the active Hypericine complex/biochemistry and clinical studies. Arzneim-Forsch 1984; 34(8): 918–920.

    CAS  Google Scholar 

  127. May, G. and G. Willuhn. Antiviral activity of aqueous extracts from medicinal plants in tissue cultures. Arzneim-Forsch 1978; 28(1): 1–7.

    CAS  Google Scholar 

  128. Vasil’chenko, E. A., L. N. Vasil’ eva, N. F. Komissarenko, I. G. Levashova and V. S. Batyuk. Analgesic action of flavonoids of Rhododendron luteum Sweet, Hypericum perforatum L., Lespedeza bicolor Turoz. and L. hedysaroides (Pall.) Kitag. Rast Resur 1986; 22(1): 12–21.

    Google Scholar 

  129. Anon. Hypericin. Aids/HIV Treatment Directory 1990; 4 (2): 25.

    Google Scholar 

  130. Leporatti, M. L. and A. Pavesi. New or uncommon uses of several medicinal plants in some areas of Central Italy. J Ethnopharmacol 1990; 29(2): 213–223.

    Article  CAS  Google Scholar 

  131. Rios, J. L., M. C. Recio and A. Villar. Antimicrobial activity of selected plants employed in the Spanish Mediterranean area. J Ethnopharmacol 1987; 21(2): 139–152.

    Article  CAS  Google Scholar 

  132. Lokar, L. C. and L. Poldini. Herbal remedies in the traditional medicine of the Venezia Giulia region (North East Italy). J Ethnopharmacol 1988; 22(3): 231–239.

    Article  CAS  Google Scholar 

  133. Abraham, A., S. D. Bhakuni, H. S. Garg, A. K. Goel, B. N. Mehrotra and G. K. Patnaik. Indian J Exp Biol 1986; 24(1986): 48–68.

    Google Scholar 

  134. Chopra, R. N., R. L. Badhwar and S. Ghosh. Poisonous plants of India. Manager of Publications, Government of India Press, Calcutta. Volume 1, 1949.

    Google Scholar 

  135. Lazareva, K. N., Z. Y. Lagno, F. A. Zarukii, N. A. Kuznetsova and R. N. Abdullina. The results of a study of some drug plants of the Bashkir ASSR. Sb Nauchn Tr Bashk Gos Med Inst 1968; 17: 54.

    Google Scholar 

  136. Broda, B., W. Jaroniewski and L. Swiatek. Occurrence of caffeic acid in some medicinal plants. Acta Pol Pharm 1960; 17: 301–306.

    CAS  Google Scholar 

  137. Snajder, K. Use of indigenous medicinal plants against dysentery and diarrhea in vicinity of Trstenik (Central Siberia). Sb Radova Sapadnika Inst Ispitivaye Lekovit Biya (Belgrade) 1951; 1951(1): 21.

    Google Scholar 

  138. Frisbey, A., J. M. Roberts, J. C. Jennings, R. Y. Gottshall and E. H. Lucas. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis (Third report). Mich State Univ Agr Appl Sci Quart Bull 1953; 35: 392–404.

    Google Scholar 

  139. Saggese, D. Medicinal Herbs of Argentina, 10th Ed. Antognazzi & Co., Rosario, 1959; 1–189.

    Google Scholar 

  140. Dragendorff, G. Die Heilpflanzen der Verschiedenen Volker und Zeiten, F. Enke, Stuttgart, 1898; 885 pp-.

    Google Scholar 

  141. Heal, R. E., E. F. Rogers, R. T. Wallace and O. Starnes. A survey of plants for insecticidal activity. Lloydia 1950; 13: 89–162.

    Google Scholar 

  142. Chopra, R. N. Indigenous Drugs of India. Their Medical and Economic Aspects. The Art Press, Calcutta, India, 1933; 550 pp-.

    Google Scholar 

  143. Anon. The Herbalist. Hammond Book Company, Hammond, Indiana, 1931; 400 pp-.

    Google Scholar 

  144. Borkowski, B. Diuretic action of several flavone drugs. Planta Med 1960; 8: 95–104.

    Article  CAS  Google Scholar 

  145. Tonero, A. Therapeutic product for the treatment of several diseases, such as rheumatism. Patent-Belg654,916 1965; 4 pp-.

    Google Scholar 

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© 2001 Springer Science+Business Media New York

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Ross, I.A. (2001). Hypericum perforatum. In: Medicinal Plants of the World. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-237-1_12

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  • DOI: https://doi.org/10.1007/978-1-59259-237-1_12

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