Abstract

Gingko biloba is a 30 to 40 m high dioecious tree of the CYCADACEAE family, with a girth of about 4 meters. The trees can live for hundreds of years. The bark is light to dark brown with rough grooves and reticulate fissures. The leaves are fan-shaped with bifurcated ribs, fresh green and golden yellow in autumn. The tree flowers for the first time when it is between 20 to 30 years old. The flowers are dioecious. They are in the axils of the lower leaves of the annual growth. The male flowering parts are attached to short catkins. The female flowers have longer pedicles and are at the end of a leafless branch. Fertilization occurs months after pollination by spermatozoids, although usually only one ovule is fully formed. The seeds later become fleshy and plum-like round and light green or yellow in color.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Weinges, K., W. Bahr and P. Kloss. Natural phenolic cornpounds. XI. Review of the components of Ginkgo biloba leaves. Arzneim-Forsch 1968; 18: 537–539.

    CAS  Google Scholar 

  2. Weinges, K., W. Bahr and P. Kloss. The phenolic constituents from the leaves of Ginkgo biloba. Arzneim-Forsch 1968; 18: 539–545.

    CAS  Google Scholar 

  3. Kircher, H. W. Beta sitosterol in Ginkgo biloba leaves. Phytochemistry 1970; 9: 1879.

    CAS  Google Scholar 

  4. Natarajan, S., V. V. S. Murti, T. R. Seshadri and A. S. Ramaswamy. Some new pharmacological pro- perties of flavonoids and biflavonoids. Curr Sci 1970; 39: 533–534.

    CAS  Google Scholar 

  5. Geiger, H. and S. Beckman. On the occurrence of rutin and kaempferol-3-rhamnoglucoside in Ginkgo biloba. Z Naturforsch Ser B 1965; 20: 1139–1140.

    Google Scholar 

  6. Weinges, K. and W. Bahr. Condensed ring systems. II. Bilobalide A, a new sesquiterpine obtained from the leaves of Ginkgo biloba and containing a tertiary butyl group. Justus Liebigs Ann Chem 1969; 1969: 214–216.

    Google Scholar 

  7. Condorelli, S., F. Tonelli, G. Galati and E. V. Cosmi. Treatment of subacute and chronic fetal asphyxia with extract of the leaves of Ginkgo biloba. Acta Anaesthesiol Ital 1972; 23: 547–559.

    Google Scholar 

  8. Miura, H., T. Kihara and N. Kawano. Studies on bisflavones in the leaves of Podocarpus macrophylla and P. nagi. Chem Pharm Bull 1969; 17: 150–154.

    CAS  Google Scholar 

  9. Fitzpatrick, F. K. Plant substances active against Mycobacterium tuberculosis. Antibiot Chemother 1954; 4: 528.

    CAS  Google Scholar 

  10. Lee, S. J. Korean Folk Medicine. Monograph Ser 3, Seoul Natl Univ Publ Ctr, Seoul, 1966.

    Google Scholar 

  11. Schramm, G. Plant and animal drugs of the old Chinese materia medica in the therapy of pulmonary tuberculosis. Planta Med 1956; 4(4): 97–104.

    Google Scholar 

  12. Okabe, K., K. Yamada, S. Yamamura and S. Takada. Ginkgolides. J Chem Soc C 1967; 1967: 2201–2206.

    Google Scholar 

  13. Fisel, J. Kaempferol, quercetin and isorhamnetin from the green leaves of Ginkgo biloba. Naturwissenschaften 1965; 52: 592A.

    Google Scholar 

  14. Major, R. T., J. S. Roth and A. S. Kuenkler. Enzymic oxidation of linolenate by ginkgo leaves fractionation and characterization of active fractions. Phytochemistry 1974; 13: 1083–1084.

    CAS  Google Scholar 

  15. Maruyama, M., A. Terahara, Y. Itagaki and Koji Nakanishi. The ginkgolides. I. Isolation and characterization of the various groups. Tetrahedron Lett 1967; 1967: 299–302.

    Google Scholar 

  16. Felber, J. P. Effect of Ginkgo biloba extract on endocrine parameters. Presse Med 1986; 15 (31): 1573–1574.

    CAS  Google Scholar 

  17. Wada, K., S. Ishigaki, K. Ueda, M. Sakata and M. Haga. An antivitamin B-6, 4′-methoxypyridoxine, from the seed of Ginkgo biloba L. Chem Pharm Bull 1985; 33(8): 3555–3557.

    CAS  Google Scholar 

  18. Plieninger, H., B. Schwarz, H. Jaggy, U. Huberpatz, H. Rodewald, H. Irngartinger and K. Weinges. Natural products from medicinal plants. XXIV. Isolation structure determination and synthesis of (Z,Z)-4.4′-(1,4-pentadiene-1,5-diyl) diphenol, an unusual natural product from leaves on the Ginkgo tree (Ginkgo biloba L.). Liebigs Ann Chem 1986; 1986(10): 1772–1778.

    Google Scholar 

  19. Wada, K., S. Ishigaki, K. Ueda, Y. Take, K. Sasaki, M. Sakata and M. Haga. Studies on the constitution of edible and medicinal plants. I. Isolation and identification of 4–0-methylpyridoxine, toxic principle from the seed of Ginkgo biloba L. Chem Pharm Bull 1988; 36(5): 1779–1782.

    CAS  Google Scholar 

  20. Kraus, J. Water-soluble polysaccharides from Ginkgo biloba leaves. Phytochemistry 1991; 30(9): 3017–3020.

    CAS  Google Scholar 

  21. Hasler, A., G. A. Gross, B. Meier and O. Sticher. Complex flavonol glycosides from the leaves of Ginkgo biloba. Phytochemistry 1992; 31(4): 1391–1394.

    CAS  Google Scholar 

  22. Choukchou-Braham, N., Y. Asakawa and J. P. Lepoittevin. Isolation, structure determination and synthesis of new dihydroisocoumarins from Ginkgo biloba L. Tetrahedron Lett 1994; 35(23): 3949–3952.

    CAS  Google Scholar 

  23. Kim, B. E., S. H. Ban, S. H. Woo and S. K. Chung. A study on the composition of Ginkgo biloba leaves. Rist Yongu Nonmun 1994; 8(1): 105–114.

    CAS  Google Scholar 

  24. Zargari, A. Medicinal Plants. Vol. 5, 4th Ed, Tehran University Publications, No 1810/5, Tehran, Iran 1991; 5: 974 pp.

    Google Scholar 

  25. Irie, H., K. Ohno, Y. Ito and S. Uyeo. Isolation and characterization of 10,11-dihydroatlantone and related compounds from Ginkgo biloba. Chem Pharm Bull 1975; 23: 1892.

    CAS  Google Scholar 

  26. Cherif, A., J. P. Dubadq, R Mache, A. Oursel and A. Tremolieres. Biosynthesis of alpha-linolenic acid by desaturation of oleic and linoleic acids in several organs of higher and lower plants and algae. Phytochemistry 1975; 14: 703–706.

    CAS  Google Scholar 

  27. Gellerman, J. L., W. H. Anderson and H. Schlenk. Biosynthesis of anacardic acids from acetate in Ginkgo biloba. Lipids 1974: 9: 722.

    CAS  Google Scholar 

  28. Becker, L. E. and G. B. Skipworth. Ginkgo-tree dermatitis, stomatitis and proctitis. J Amer Med Ass 1975; 231: 1162.

    CAS  Google Scholar 

  29. Pietri, S., J. R. Seguin, P. D’Arbigny, K. Drieu and M. Culcasi. Ginkgo biloba extract (EGB 761) pretreatment limits free radical-induced oxidative stress in patients undergoing coronary bypass surgery. Cardiovasc Drugs Ther 1997; 11(2): 121–131.

    CAS  Google Scholar 

  30. Rapin, J. R., R. G. Yoa, C. Bouvier and K. Drieu. Effects of repeated treatments with an extract of Ginkgo biloba (EGB 761) and bilobalide on liver and muscle glycogen contents in the noninsulin dependent diabetic rat. Drug Dey Res 1997; 40(1): 68–74.

    CAS  Google Scholar 

  31. Wang, J., B. Yu, X. G. Liu and Y. M. Zhang. Isolation and identification of the constituents from episperm of ginkgo (Ginkgo biloba). Chung Ts’al Yao 1995; 26(6): 290–292.

    CAS  Google Scholar 

  32. Rong, Y., Z. Geng and B. H. S. Lau. Ginkgo biloba modulates glutathione redox cycle in vascular endothelial cells. Nutr Res 1996; 16(11/12): 1913–1923.

    Google Scholar 

  33. Rowin, J. and S. L. Lewis. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996; 46(6): 1775–1776.

    CAS  Google Scholar 

  34. Chung, K. F., M. M. McCusker, C. P. Page, G. Dent, P. Guinot and P. J. Barnes. Effect of a ginkgolide mixture (BN 52063) in antagonizing skin and platelet responses to platelet activating factor in man. Lancet 1987; 1987: 248–251.

    Google Scholar 

  35. Le Bars, P. L., M. M. Katz, N. Berman, T. M. Itil, A. M Freedman and A. F. Schatzberg. A placebo-controlled, double-blind randomized trial of an extract of Ginkgo biloba for dementia. J Amer Med Ass 1997; 278(16): 1327–1332.

    Google Scholar 

  36. Kobuchi, H., M. T. Droy-Lefaix, Y. Christen and L. Packer. Ginkgo biloba extract (EGB 716): Inhibitory effect on nitric oxide production in the macrophage cell line raw 264.7. Biochem Pharmacol 1997; 53(6): 897–903.

    CAS  Google Scholar 

  37. Pan, J. X., H. Y. Zhang, W. B. Tang and M. F. Hong. Biflavones from the testa of Ginkgo biloba L. Zhiwu Ziyuan Yu Huan**g 1995; 4(2): 17–21.

    Google Scholar 

  38. Laurain, D., J. TremouillauxGuiller, J. C. Chenifux and T. A. Van Beek. Production of ginkgolide and bilobalide in transformed and gametophyte derived cell cultures of Ginkgo biloba. Phytochemistry 1997; 46(1): 127–130.

    CAS  Google Scholar 

  39. Sastre, J., R. Pla, G. Juan, A. Millan, F. V. Pallardo, J. G. De La Asuncion, J. A. Marin, E. O’Connor, M. T. Droy-Lefaix, et al. Prevention by Ginkgo biloba extract (EGB 761) of age-associated impairment of brain mitochondria. Proc Int Symp Nat Antioxid Mol Mech Health Eff 1995; 1995: 434–443.

    Google Scholar 

  40. Smith, P. F., K. Maclennan and C. L. Darlington. The neuroprotective properties of the Ginkgo biloba leaf: A review of the possible relationship of plateletactivating factor (PAF). J Ethnopharmacol 1996; 50(3): 131–139.

    CAS  Google Scholar 

  41. Koc, R. K., H. Akdemir, A. Kurtsov, H. Pasaoglu, I. Kavuncu, A. Passaoglu and I. Karakucuk. Lipid peroxidation in experimental spinal cord injury: Comparison of treatment with Ginkgo biloba, TRH and methylprednisolone. Res Exp Med 1995; 195(2): 117–123.

    CAS  Google Scholar 

  42. Kose, K., P. Dogan, M. Ascioglu and O. Ascioglu. In vitro antioxidant effect of Ginkgo biloba extract (EGB 761) on lipoperoxidation induced by hydrogen peroxide in erythrocytes of EBHCET’s patients. Jap J Pharmacol 1997; 75(3): 253–258.

    CAS  Google Scholar 

  43. Sastre, J., A. Millan, J. G. De La Asuncion, R. Pla, G. Juan, F. V. Pallardo, E. O’Connor, J. A. Martin, M. T. Droy-Lefaix and J. Vina. A Ginkgo biloba extract (EGB 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radical Biol Med 1998; 24(2): 298–304.

    CAS  Google Scholar 

  44. Lang, F. and E. Wilhelm. Quantitative determination of proanthocyanidins in Ginkgo biloba special extracts. Pharmazie 1996; 51(10): 734–737.

    CAS  Google Scholar 

  45. Bolanos-Jimenzs, F., R. M. Castro, H. Sarhan, N. Prudhomme, K. Drieu and G. Fillion. Stressinduced 5-HTIA receptor desensitization protective effects of Ginkgo biloba extract (EGB 761). Fundam Clin Pharmacol 1995; 9(2): 169–174.

    Google Scholar 

  46. Amri, H., K. Drieu and V. Papadopoulos. Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the Ginkgo biloba extract EGB 761 and isolated ginkgolide B. Endocrinology 1997; 138(12): 5412–5426.

    Google Scholar 

  47. Hasler, A., O. Sticher and B. Meier. Identification and determination of the flavonoids from Ginkgo biloba by high-performance liquid chromatography. J Chromatogr 1992; 605(1): 41–48

    CAS  Google Scholar 

  48. Castelli, D., L. Colin, E. Camel and G. Ries. Pretreatment of skin with a Ginkgo biloba extract sodium carboxymethyl-beta-1, 3-glucan formulation appears to inhibit the elicitation of allergic contact dermatitis in man. Contact Dermatitis 1998; 38(3): 123–126.

    CAS  Google Scholar 

  49. Schulz, V., W. D. Hubner and M. Ploch. Clinical trials with phyto-psychopharmacological agents. Phytomedicine 1997; 4(4): 379–387.

    CAS  Google Scholar 

  50. Winter, J. C. The effects of an extract of Ginkgo biloba, EGB 761, on cognitive behavior and longevity in the rat. Physiol Behav 1998; 63(3): 425–433.

    CAS  Google Scholar 

  51. Cohen-Salmon, C., P. Venault, B. Martin, M. J. Raffalli-Sebille, M. Barkats, F. Clostre, M. C. Pardon and G. Chapouthier. Effects of Ginkgo biloba extract (EGB 761) on learning and possible actions on aging. J Physiol (Paris) 1997; 91(6): 291–300.

    CAS  Google Scholar 

  52. Ghosal, S., R. Sundaram, A. V. Muruganandam, S. K. Singh, K. S. Satyan, S. K. Bhattacharya, V. Saravanan and N. Mishra. The chemistry and action of 6-alkysalicylates of Indian Ginkgo biloba. Indian J Chem 1997; 36B(3): 257–263.

    CAS  Google Scholar 

  53. Hasenohri, R. U., B. Topic, C. Frisch, R. Hacker, C. M. Mattern and J. P. Huston. Dissociation between anxiolytic and hypomnestic effects for combined extracts of Zingiber officinale and Ginkgo biloba, as opposed to diazepam. Pharmacol Biochem Behav 1998; 59(2): 527–535.

    Google Scholar 

  54. Arnould, T., C. Michiels, D. Janssens, N. Brna and J. Remacle. Effect of gonkor fort on hypoxia-induced neutrophil adherence to human saphenous vein endothelium. J Cardiovacs Pharmacol 1998; 31(3): 456–463.

    CAS  Google Scholar 

  55. Han, D. S. Crude drugs inducing allergic reaction on Ginkgo biloba. Yakhak Hoe Chi 1975; 19: 79–86.

    CAS  Google Scholar 

  56. Gellerman, J. L., W. H. Anderson and H. Schlenk. 6-(pentadec-8-enyl)-2,4-dihydroxybenzoic acid from seeds of Ginkgo biloba. Phytochemistry 1976; 15: 1959–1961.

    CAS  Google Scholar 

  57. Flesch, V., M. Jacques, L. Cosson, B. P. Teng, V. Petiard and J. P. Balz. Relative importance of growth and light level on terpene content of Ginkgo biloba. Phytochemistry 1992; 31 (6): 1941–1945.

    CAS  Google Scholar 

  58. Beljanski, M. Virucidal composition comprising flavopereirine. Patent-Eur Pat Appl-373,986 1990; 7 pp.

    Google Scholar 

  59. Schneider, B. Ginkgo biloba extract in peripheral arterial disease/meta-analysis of controlled clinical trials. Arzneim-Forsch 1992; 42(4): 428–436.

    CAS  Google Scholar 

  60. Yabe, I., M. Chat, E. Malherne and P. P. Vidal. Effects of Ginkgo biloba extract (EGB 761) on the guinea pig vestibular system. Pharmacol Biochem Behav 1992; 42(4): 595–604.

    CAS  Google Scholar 

  61. Dumont, E., E. Petit, T. Tarraade and A. Nouvelot. UV-C irradiation-induced peroxidative degra dation of microsomal fatty acids and proteins: Protection by an extract of Ginkgo biloba (EGB 761). Free Radical Biol Med 1992; 13(3): 197–203.

    CAS  Google Scholar 

  62. Markham, K. R., H. Geiger and H. Jaggy. Kaempferol-3-O-glucosyl(1–2)rhamnoside from Ginkgo biloba and a reappraisal of other gluco(1–2,1–3 and 1–4)rha mnoside structures. Phytochemistry 1992; 31(3): 1009–1011.

    CAS  Google Scholar 

  63. Gulz, P. G., E. Muller, K. Schmitz, F. J. Marner and S. Guth. Chemical composition and surface structures of epicuticular leaf waxes of Ginkgo biloba, Magnolia grandiflora and Liriodendron tulipfera. Z Naturforsch Ser C 1992; 47(7/8): 516–526.

    Google Scholar 

  64. Huh, H., E. J. Staba and J. Singh. Supercritical fluid chromatographic analysis of polyprenols in Ginkgo biloba L. J Chromatogr 1992; 600(2): 364–369.

    CAS  Google Scholar 

  65. Van Beek, T. A. and G. P. Lelyveld. Concentration of ginkgolides and bilobalide in Ginkgo biloba leaves in relation to the time of year. Planta Med 1992; 58(5): 413–416.

    Google Scholar 

  66. Kiesewetter, H., F. Jung, C. Mrowietz and E. Wenzel. Hemorrheological and circulatory effects of gincosan. Int J Clin Pharmacol Ther Toxicol 1992; 30(3): 97–102.

    CAS  Google Scholar 

  67. Woerdenbag, H. J. Therapy with leaf extract of Ginkgo biloba. Pharm Weekblad 1993; 128(4): 102–106.

    CAS  Google Scholar 

  68. Ramassamy, C., Y. Christen, F. Clostre and J. Costentin. The Ginkgo biloba extract, EGB 761, increases synaptosomal uptake of 5-hydroxytryptamine: In-vitro and ex-vivo studies. J Pharm Pharmacol 1992; 44 (11): 943–945.

    CAS  Google Scholar 

  69. Oyama, Y., T. Ueha, A. Hayashi, J. Chikahisa and K. Noda. Flow cytometric estimation of the effect of Ginkgo biloba extract on the content of hydrogen peroxide in dissociated mammalian brain neurons. Jap J Pharmacol 1992; 60(4): 385–388.

    CAS  Google Scholar 

  70. Wada, K., K. Sasaki, K. L. Miura, M. Yagi, Y. Kubota, T. Matsumoto and M. Haga. Isolation of the bilobalide and ginkgolide A from Ginkgo biloba L. shorten the slee** time induced in mice by anesthetics. Biol Pharm Bull 1993; 16(2): 210–212.

    CAS  Google Scholar 

  71. Yasukawa, K., A. Yamaguchi, J. Arita, S. Sakurai, A. Ikeda and M. Takido. Inhibitory effect of edible plant extracts on 12-o-tetradecanoylphorbol-13-acetate-induced ear oedema in mice. Phytother Res 1993; 7(2): 185–189.

    CAS  Google Scholar 

  72. Allain, H., P. Raoul, A. Lieury, F. Lecoz, J. M Gandon and P. D’Arbigny. Effect of two doses of Ginkgo biloba extract (EGB 761) on the dual-coding test in elderly subjects. Clin Ther 1993; 15(3): 549–558.

    CAS  Google Scholar 

  73. De Turco, E. B. R., M. T. DroyLefaix and N. G. Bazan. EGB 761 inhibits stress-induced polydipsia in rats. Physiol Behav 1993; 53(5): 1001–1002.

    Google Scholar 

  74. Verotta, L. and F. Peterlongo. Selective extraction of phenolic components from Ginkgo biloba extracts using supercritical carbon dioxide and off-line capillary gas chromatography/mass spectrometry. Phytochem Anal 1993; 4 (4): 178–182.

    CAS  Google Scholar 

  75. Kang, G. S., J. R. Youm and S. S. Kang. Seasonal variations of the flavonol glycoside content from Ginkgo biloba leaves. Korean J Pharmacog 1993; 24(1): 47–53.

    CAS  Google Scholar 

  76. Yagi, M., K. Wada, M. Sakata, M. Kokubo and M. Haga. Studies on the constituents of edible and medicinal plants. IV. Determination of 4-o-methylpyridoxine in serum of the patient with gin-nan food poisoning. Yakugaku Zasshi 1993; 113(8): 596–599.

    CAS  Google Scholar 

  77. Yu, X. Y., X. P. Zhuang, P. Braquet and Y. J. Fang. The analysis of ginkgolide B from leaves of Ginkgo biloba L. by high-performance liquid chromatography. Yaowu Fenxi Zazhi 1993; 13(2): 85–88.

    CAS  Google Scholar 

  78. Sandberg-Gertzen, H. An open trail of cedemin, Ginkgo biloba extract with PAF-antagonistic effects for ulcerative colitis. Amer J Gastroenterol 1993; 88(4): 615–616.

    CAS  Google Scholar 

  79. Kang, G. S., J. R. Youm and S. S. Kang. Seasonal variations of the flavonol glycoside content from Ginkgo biloba leaves. Korean J Pharmacog 1993; 24(1): 47–53.

    CAS  Google Scholar 

  80. Zhuang, X. P., X. Y. Xu, G. S. Yan and Y. Q. Fang. Determination of total flavonoids in the leaves of ginkgo (Ginkgo biloba) and studies on its extraction process. Chung Ts’ao Yao 1992; 23(3): 122–124.

    CAS  Google Scholar 

  81. Vasseur, M., T. Jean, F. V. Defeudis and K. Drieu. Effects of repeated treatments with an extract of Ginkgo biloba (EGB 761), bilobalide and ginkgolide B on the electrical activity of pancreatic B cells of normal of alloxan-diabetic mice: An ex vivo study with intracellular microelectrodes. Gen Pharmac 1994; 25(1): 31–46.

    CAS  Google Scholar 

  82. Hughet, F., K. Drieu and A. Piriou. Decreased cerebral 5HT-1-A receptors during aging: Reversal by Ginkgo biloba extract (EGB 761). J Pharm Pharmacol 1994; 46(4): 316–318.

    Google Scholar 

  83. Masson, F., G. Neliat, K. Drieu, F. V. Defeudis and T. Jean. Effects of an extract of Ginkgo biloba on the action potential and associated transmembrane ionic currents in mammalian cardiac myocytes: Inhibition of isoproterenol-induced chloride current. Drug Dev Res 1994; 32(1): 29–41.

    CAS  Google Scholar 

  84. Kurokawa, M., H. Ochiai, K. Nagasaka, M. Neki, H. X. Xu, S. Kadota, S. Sutardio, T. Matsumoto, T. Namba and K. Shiraki. Antiviral traditional medicines against herpes simplex virus (HSV-1), poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV-1 infection in mice. Antiviral Res 1993; 22(2/3): 175–188.

    CAS  Google Scholar 

  85. Marcocci, L., J. L. Maguire, M. T. Droy-Lefaix and L. Packer. The nitric oxide-scavenging properties of Ginkgo biloba extract EGB 761. Biochem Biophys Res Commun 1994; 201 (2): 748–755.

    CAS  Google Scholar 

  86. Pietta, P., P. Mauri and A. Raya. Rapid liquid chromatography of terpenes in Ginkgo biloba L. extracts and products. J Pharm Biomed Anal 1992; 10(10/12): 1077–1079.

    CAS  Google Scholar 

  87. Della Loggia, R., S. Sosa, A. Tubaro and E. Bombardelli. Anti-inflammatory activity of Ginkgo biloba flavonoids. Planta Med Suppl 1993; 59(7): A588.

    Google Scholar 

  88. Barkats, M., P. Vanault, Y. Christen and C. Cohen-Salmon. Effect of long-term treatment with EGB 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains. Life Sci 1995; 56(4): 213–222.

    CAS  Google Scholar 

  89. Pritz-Hohmier, S., T. I. Chao, J. Krenzlin and A. Reichenbach. Effect of in vivo application of the Ginkgo biloba extract EGB 761 (Rokan) on the susceptibility of mammalian retinal cells to proteolytic enzymes. Opthalmic Res 1994; 26(2): 80–86.

    Google Scholar 

  90. Matile, P., B. M. P. Flach and B. M. Eller. Autumn leaves of Ginkgo biloba L.: Optical properties, pigments and optical brighteners. Bot Acta 1992; 105 (1): 13–17.

    CAS  Google Scholar 

  91. Dorman, D. C., L. M. Cote and W. B. Buck. Effects of an extract of Ginkgo biloba on bromethalin-induced cerebral lipid peroxidation and edema in rats. Amer J Vet Res 1992; 53(1): 138–142.

    CAS  Google Scholar 

  92. Haramaki, N., S. Aggarwal, T. Kawabata, M. T. T. Droy-Lefaix and L. Packer. Effects of natural antioxidant Ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion injury. Free Radical Biol Med 1994; 16(6): 789–794.

    CAS  Google Scholar 

  93. Kose, K. and P. Dogan. Lipoperoxidation induced by hydrogen peroxide in human erythrocyte membranes. 1. Protective effect of Ginkgo biloba extract (EGB 761). J Int Med Res 1995; 23(1): 1–8.

    CAS  Google Scholar 

  94. Kose, K. and P. Dogan. Lipoperoxidation induced by hydrogen peroxide in human erythrocyte membranes. 2. Comparison of the antioxidant effect of Ginkgo biloba extract (EGB 761) with those of water-soluble and lipid-soluble antioxidant. J Int Med Res 1995; 23(1): 9–18.

    CAS  Google Scholar 

  95. Shen, J. G. and D. Y. Zhou. Efficiency of Ginkgo biloba extract (EGB 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochem Mol Biol Int 1995; 35(1): 125–134.

    CAS  Google Scholar 

  96. Vennat, J. C., M. T. DroyLefaix, G. Besse and M. Doly. Prevention of chloroquine-induced electroretinogram alterations by Ginkgo biloba extract (EGB 761) in rat. Int Congr Ser-Excerpta Med 1992; 998: 761–764.

    CAS  Google Scholar 

  97. Kenzelmann, R. and F. Kade. Limitation of the deterioration of lipid parameters by a standardized garlic ginkgo combination product. A multicenter placebocontrolled double-blind study. Arzneim-Forsch 1993; 43(9): 978–981.

    CAS  Google Scholar 

  98. Struillou, L., Y. Cohen, J. L. Vilde, J. J. Pocidalo and C. Perronne. Ginkgo biloba extract EGB 761 is not active against Mycobacterium avium infection in C57BL/6 mice. Antimicrob Agents Chemother 1995; 39(4): 1013–1014.

    CAS  Google Scholar 

  99. Emerit, I., R. Arutyunyan, N. Oganesian, A. Levy, L. Cernjaysky, T. Sarkisian, A. Pogossian and K. Asrian. Radiation-induced clastogenic factors: Anticlastogenic effect of Ginkgo biloba extract. Free Radical Biol Med 1995; 18(6): 985–991.

    CAS  Google Scholar 

  100. Kim, B. Y., G. C. Lee, W. K. Whang and J. D. Huh. Studies on the extraction of active components in Ginkgo biloba L. leaves by enzyme treatment (I). Korean J Pharmacog 1989; 20(1): 43–47.

    CAS  Google Scholar 

  101. Maitra, I., L. Marcocci, M. T. Droy-Lefaix and L. Packer. Peroxyl radical scavenging activity of Ginkgo biloba extract EGB 761. Biochem Pharmacol 1995; 49(11): 1649–1655.

    CAS  Google Scholar 

  102. Agnoli, A., J. R. Rapin, V. Scapagnini and W. V. Weitbrecht. Effects of Ginkgo biloba extract on organic cerebral impairment. Effects of Ginkgo biloba extract on organic cerebral impairment. A. Agnoli, J. R. Rapin, V. Scapagnini, W. V. Weitbrecht, John Libbey, Eurotext LTD 1984; 1985(1984): 43–49.

    Google Scholar 

  103. Kang, S. S., Y. M. Koh, J. S. Kim, M. W. Lee and D. S. Lee. Phytochemical analysis of Ginkgo biloba yellow leaves. Korean J Pharmacog 1995; 26(1): 23–26.

    CAS  Google Scholar 

  104. Duche, J. C., J. Barre, P. Guinot, J. Duchier, A. Cournot and J. P. Tillement. Effect of Ginkgo biloba extract on microsomal enzyme induction. Int J Clin Pharmacol Res 1989; 9(3): 165–168.

    CAS  Google Scholar 

  105. Dumont, E., P. D. Arbigny and A. Nouvelot. Protection of polyunsaturated fatty acids against iron-dependent lipid peroxidation by a Ginkgo biloba extract (EGB 761). Meth Find Exp Clin Pharmacol 1995; 17 (2): 83–88.

    CAS  Google Scholar 

  106. Szabo, M. E., M. T. Droy-Lefaix and M. Doly. EGB 761 and the recovery of ion imbalance in ischemic reperfused diabetic rat retina. Opthalmic Res 1995; 27 (2): 102–109.

    CAS  Google Scholar 

  107. Shen, Z. B. and X. N. Chen. Polyprenols from Ginkgo biloba leaves. Linchan Huaxue Yu Gongye 1992; 12(4): 279–286.

    Google Scholar 

  108. Duverger, D., F. Defeudis and K. Drieu. Effects of repeated treatments with an extract of Ginkgo biloba (EGB 761) on cerebral glucose utilization in the rat: An autoradiographic study. Gen Pharmacol 1995; 26(6): 1375–1383.

    CAS  Google Scholar 

  109. Yan, L. J., M. T. Droy-Lefaix and L. Packer. Ginkgo biloba extract (EGB 761) protects human low density lipoproteins against oxidative modification mediated by copper. Biochem Biophys Res Commun 1995; 212(2): 360–366.

    CAS  Google Scholar 

  110. Moore, B. D., E. Isidoro and J. R. Seemann. Distribution of 2-carboxyarabinitol among plants. Phytochemistry 1993; 34(3): 703–707.

    CAS  Google Scholar 

  111. Frisch, C., R. U. Hasenohri, C. M. Mattem, R. Hacker and J. P. Huston. Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents: Comparison of metoclopramide with combined extracts of Zingiber officinale and Ginkgo biloba. Pharmacol Biochem Behav 1995; 52(2): 321–327.

    CAS  Google Scholar 

  112. Itil, T. and D. Martorano. Natural substances in psychiatry (Ginkgo biloba in dementia). Psychopharmacol Bull 1995; 31(1): 147–158.

    CAS  Google Scholar 

  113. Krieglstein, J., F. Ausmeier, H. El-Abhar, K. Lippert, M. Welsch, K. Rupalla and P. HenrichNoack. Neuroprotective effects of Ginkgo biloba constituents. Eur J Pharmacol Sci 1995; 3(1): 39–48.

    CAS  Google Scholar 

  114. Cott, J. Medicinal plants and dietary supplements: Sources for innovative treatments of adjuncts. Psychopharmacol Bull 1995; 31(1): 131–137.

    CAS  Google Scholar 

  115. Janssens, D., C. Michiels, E. Delaive, F. Eliaers, K. Drieu and J. Remacle. Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem Pharmacol 1995; 50(7): 991–999.

    CAS  Google Scholar 

  116. Agar, A., P. Yargicoglu, K. C. Apaydin and Y. Oguz. The effect of Ginkgo biloba extract on EEG spectra in experimental diabetes; no relation to lipid peroxidation. Int J Neurosci 1994; 76(3/4): 259–266.

    CAS  Google Scholar 

  117. Pietta, P. G., C. Gardana, P. L. Mauri, R. Maffei-Facino and M. Carini. Identification of flavonoid metabolites after oral administration to rats of a Ginkgo biloba extract. J Chromatogr B 1995; 673(1): 75–80.

    CAS  Google Scholar 

  118. Zhong, Y. A. and L. S. Xu. Extraction, isolation and HPLC determination of biflavones in Ginkgo biloba L. Yao Hsueh Hsueh Pao 1995; 30(9): 694–697.

    CAS  Google Scholar 

  119. Hasenohri, R. U., C. H. Nichau, C. H. Frisch, M. A. D. S. Silva, J. P. Huston, C. M. Mattem and R. Hacker. Anxiolytic-like effects of combined extracts of Zingiber officinale and Ginkgo biloba in the elevated plus-maze. Pharmacol Biochem Behav 1996; 53(2): 271–275.

    Google Scholar 

  120. Emerit, J., N. Oganesian, T. Sarkisian, R. Arutyunyan, A. Pogosian, K. Asrian, A. Levy and L. Cernjayski. Clastogenic factors in the plasma of Chernobyl accident recovery workers: Anticlastogenic effect of Ginkgo biloba extract. Radiation Res 1995; 144(2): 198–205.

    CAS  Google Scholar 

  121. Irie, J., M. Murata and S. Homma. Glycerol-3-phosphate dehydrogenase inhibitors, anacardic acids, from Ginkgo biloba. Biosci Biotech Biochem 1996; 60(2): 240–243.

    CAS  Google Scholar 

  122. Kang, S. S., J. S. Kim, W. J. Kwak and K. H. Kim. Structures of two acylated flavonol glucorhamnosides from Ginkgo biloba leaves. Arch Pharm Res 1990; 13(2): 207–210.

    CAS  Google Scholar 

  123. Ramassamy, C., F. Girbe, Y. Christen and J. Costentin. Ginkgo biloba extract EGB 761 or trolox c prevent the ascorbic acid/FE2+ induced decrease in synaptosomal membrane fluidity. Free Radical Res Commun 1993; 19(5): 341–350.

    CAS  Google Scholar 

  124. Rong, Y. Q., Z. H. Geng and B. H. S. Lau. Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radical Biol Med 1996; 20(1): 121–127.

    CAS  Google Scholar 

  125. Seif-El-Nasr, M. and A. A. B. El-Fattah. Lipid peroxide, phospholipids, glutathione levels and superoxide dismutase activity in rat brain after ischaemia: Effect of Ginkgo biloba extract. Pharmacol Res 1995; 32(5): 273–278

    CAS  Google Scholar 

  126. Mizuno, M., M. T. D. Lefaix and L. Packer. Ginkgo biloba extract EGB 761 as a suppressor of AP1 transcription factor stimulated by phorbol 12-myristate 13-acetate. Biochem Mol Biol Int 1996; 39(2): 395–401.

    CAS  Google Scholar 

  127. Vesper, J. and K. D. Hansgen. Efficacy of Ginkgo biloba in 90 outpatients with cerebral insufficiency caused by old age. Results of a placebo-controlled double-blind trial. Phytomedicine 1994; 1(1): 9–16.

    CAS  Google Scholar 

  128. Wojcicki, J., J. Samochowiec, S. Juzwiak, B. Gonet, W. Syrnski, B. Barcew-Wiszniewska, L. Rozewicka, S. Tustanowski, M. Ceglecka, Z. Juzyszyn, Z. Mysliwiec, M. Kaldonska, W. Gornik and D. Kadlubowska. Ginkgo biloba extract inhibits the development of experimental atherosclerosis in rabbits. Phytomedicine 1994; 1(1): 33–38.

    CAS  Google Scholar 

  129. Park, S. Y. and Y. W. Kim. Screening and isolation of the antitumor agents from medicinal plants. (II). Seoul Univ J Pharm Sci 1992; 17: 1–5.

    CAS  Google Scholar 

  130. O’Reilly, J. Extract from the leaves of Ginkgo biloba. PatentPct Int Appl-95 15,172 1995; 20 nn.

    Google Scholar 

  131. Ni, Y., B. Zhao, J. W. Hou and W. J. **n. Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals. Neurosci Lett 1996; 214 (2/3): 115–118.

    CAS  Google Scholar 

  132. Hierro, M. T. G., G. Robertson, W. W. Christie and Y. C. Joh. The fatty acid composition of the seed of Ginkgo biloba. J Amer Oil Chem Soc 1996; 73(5): 575–579.

    CAS  Google Scholar 

  133. Arenz, A., M. Klein, K. Fiehe, J Grob, C. Drewke, T. Hemscheid and E. Leistner. Occurrence o neurotoxic 4′-o-methylpyridoxine in Ginkgo biloba leaves ginkgo medications and Japanese ginkgo food. Planta Med 1996; 62(6): 548–551.

    CAS  Google Scholar 

  134. Takatsuki, S., T. Narui, H. Ekimoto, H. Abuki, K. Nijima anc T. Okuyama. Studies on cytotoxic activity of animal and plant and crude drugs. Nat Med 1996: 50(2): 145–157.

    Google Scholar 

  135. Paick, J. S. and J. H. Lee. An experimental study of the effect of Ginkgo biloba extract on the human and rabbit Corpus cavernosum tissue. J Urol 1996; 156 (5): 1876–1880.

    CAS  Google Scholar 

  136. Mazzanti, G., L. Braghiroli, P. Bolle, A. Saija and L. Saso. Effects of Panax ginseng and Ginkgo biloba on in vitro prolactin secretion. Phytother Res 1996; 10: S33–S35.

    Google Scholar 

  137. Duke, J. A. and E. S. Ayensu. Medicinal Plants of China. Reference Publications, Inc. Algonac, Michigan, 1985. 1985; 1(4): 52–361.

    Google Scholar 

  138. Oyama, Y., L. Chikahisa, T. Ueha, K. Kancemaru and K. Noda. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Res 1996; 712(2): 349–352.

    CAS  Google Scholar 

  139. Rasetti, M. F., D. Caruson, G. Galli and E. Bosisio. Extracts of Ginkgo biloba leaves and Vaccinium myrtillus L. fruits prevent photo induced oxidation of low density lipoprotein cholesterol. Phytomedicine 1996; 3(4): 335–338.

    Google Scholar 

  140. Brantner, A. and E. Grein. Antibacterial activity of plant extracts used externally in traditional medicine. J Ethnopharmacol 1994; 44(1): 35–40.

    CAS  Google Scholar 

  141. Belougne, E., O. Aguejouf, P. Imbault, O. F. Azougagh, F. Doutremepuich, M. T. DroyLefaix and C. Doutremepuich. Experimental thrombosis model induced by laser beam. Application of aspirin and an extract of Ginkgo biloba: EGB 761. Thrombosis Res 1996; 82(5): 453–458.

    CAS  Google Scholar 

  142. Chermat, R., D. Brochet, F. V. De Feudis and K Drieu. Interactions of Ginkgo biloba extract (EGB 761), diazepam and ethyl beta-carboline-3-carboxylate on social behavior of the rat. Pharmacol Biochem Behav 1997; 56(2): 333–339.

    CAS  Google Scholar 

  143. Anton, R. Ginkgo and vascular disorders. Plant Med Phytother 1977; 118: 189.

    Google Scholar 

  144. Schrall, R. and H. Becker. Production of catechins and oligomeric proanthocyanidins in tissue and suspension cultures of Crataegus monogyna. Planta Med Suppl 1977; 32: 297–307.

    CAS  Google Scholar 

  145. Karcher, L., P. Zagermann and J. Krieglstein. Effect of an extract of Ginkgo biloba on rat brain energy metabolism on hypoxia. Naunun-Schmiedeberg’s Arch Pharmacol 1984; 327(1): 31–35.

    CAS  Google Scholar 

  146. Schennen, A. and J. Holzl. 6-Hydroxykynurenic acid, the first n-containing compound from the Ginkgo biloba leaf. Planta Med 1986; 1986(3): 235–236.

    Google Scholar 

  147. Nasri, C., A. Lobstein-Guth, M. Haag-Berrurier and R. Anton. Quercetin coumaroyl glucohamnoside from Ginkgo biloba. Phytochemistry 1987; 26(10): 2869–2870.

    Google Scholar 

  148. Matsumoto, T. and T. Sei. Antifeedant activities of Ginkgo biloba L. components against the larva of Pieris rapae crucivora. Agr Biol Chem 1987; 51(1): 249–250.

    CAS  Google Scholar 

  149. Anon. Preparation and definition of Ginkgo biloba extract. Presse Med 1986; 15(31): 1455–1457.

    Google Scholar 

  150. Bourgain, R. H., L. Maes, R. Andries and P. Braquet. Thrombus induction by endogenic PAF-acether and its inhibition by Ginkgo biloba extracts in the guinea pig. Prostaglandins 1986; 32(1): 142–144.

    CAS  Google Scholar 

  151. Bourgain, R. H., R. Andries and P. Braquet. Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. Adv Prost Thromb Leuk Res 1987; 17: 815–817.

    Google Scholar 

  152. Lagrue, G., K. Rahbar, A. Behar, A. Sobel and J. Laurent. Recurrent shock associated with monoclonal gammapathie. Acute and chronic treatment with parenteral and oral Ginkgo biloba extract. Presse Med 1986; 15(31): 1546–1549.

    Google Scholar 

  153. Bauer, U. Ginkgo biloba extract in the treatment of lower limb arteritis. A sixty-week trial. Presse Med 1986; 15(31): 1546–1549.

    CAS  Google Scholar 

  154. Moreau, J. P., U. K. Eck, J. McCabe and S. Skinner. Absorption, distribution and elimination of radiolabelled Ginkgo biloba leaves extract in the rat. Presse Med 1986; 15(31): 1458–1461.

    CAS  Google Scholar 

  155. Racagni, G., N. Brunello and R. Paoletti. Variations of neuromediators in cerebral aging. Effects of Ginkgo biloba extract. Presse Med 1986; 15(31): 1488–1490.

    CAS  Google Scholar 

  156. Hindmarch, I. Activity of Ginkgo biloba extract on short term memory. Presse Med 1986; 15 (31): 1592–1594.

    CAS  Google Scholar 

  157. Dubreuil, C. Comparative therapeutic trial of Ginkgo biloba extract and nicergoline in acute cochlear deafness. Presse Med 1986; 15(31): 1559–1561.

    CAS  Google Scholar 

  158. Meyer, B. A mulitcentre, randomized, double-blind drug versus placebo study of Ginkgo biloba extract in the treatment of tinnitus. Presse Med 1986; 15 (31): 1562–1564.

    CAS  Google Scholar 

  159. Hannequin, D., A. Thibert and Y. Vaschalde. Development of a model to study the anti-oedema properties of Ginkgo biloba extract. Presse Med 1986; 15(31): 1575–1576.

    CAS  Google Scholar 

  160. Tailander, J., A. Ammar, J. P. Rabourdin, J. P. Ribeyre, J. Pichon, S. Niddam and H. Pierart. Ginkgo biloba extract in the treatment of cerebral disorders due to aging. Presse Med 1986; 15(31): 1583–1587.

    Google Scholar 

  161. Lagrue, G., A. Behar, M. Kazandjian and K. Rahbar. Idiopathic cyclic oedema. Role of capillary hyperpermeability and its correction by Ginkgo biloba extract. Presse Med 1986; 15(31): 1550–1553.

    CAS  Google Scholar 

  162. Vanhaelen, M. and R. Vanhaelen-Fastre. Countercurrent chromatography for isolation of flavonol glycosides from Ginkgo biloba leaves. J Liq Chromatogr 1988; 11(14): 2969–2975.

    CAS  Google Scholar 

  163. Victoire, C., M. Haag-Berrurier, A. Lobstein-Guth, J. P. Balz and R. Anton. Isolation of flavonol glycosides from Ginkgo biloba leaves. Planta Med 1988; 54(3): 245–247.

    CAS  Google Scholar 

  164. Lobstein-Guth, A., F. BriandonScheid, C. Victoire, M. HaagBerrurier and R. Anton. Isolation of amentoflavone from Ginkgo biloba. Planta Med 1988; 54(6): 555–556.

    CAS  Google Scholar 

  165. Yadav, S., P. K. Ralhan and S. P. Singh. Qualitative distribution pattern of carotenoids in three selected gymnosperms. Curr Sci 1987; 56(8): 354–359.

    CAS  Google Scholar 

  166. Jensen, U. and H. Bertholdi. Legumin-like proteins in gymnosperms. Phytochemistry 1989; 28(5): 1389–1394.

    CAS  Google Scholar 

  167. Vanhaelen, M. and R. Vanhaelen-Fastre. Flavonol triglycosides from Ginkgo biloba. Planta Med 1989; 55(2): 202.

    CAS  Google Scholar 

  168. Pidoux, B. Effects of Ginkgo biloba extract on functional activity of the brain. Results of clinical and experimental studies. Presse Med 1986; 15(31): 1588–1591.

    CAS  Google Scholar 

  169. Pincemail, J., M. Dupuis, C. Nasr, P. Hans, M. Haag-Berrurier, R. Anton and C. Deby. Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract. Experentia 1989; 45(8): 708–712.

    CAS  Google Scholar 

  170. Bruel, A., J. Gardette, E. Berrou, M. T. Droy-Lefaix and J. Picard. Effects of Ginkgo biloba extract on glucose transport and glycogen synthesis of cultured smooth muscle cells from pig. Pharmacol Res 1989; 21(4): 421–429.

    CAS  Google Scholar 

  171. Taylor, J. E. Binding of neuromediators to their receptors in rat brain. Effect of chronic administration of Ginkgo biloba extract. Presse Med 1986; 15(31): 1491–1493.

    CAS  Google Scholar 

  172. Le Poncin Lafitte, M., J. Rapin and J. R. Rapin. Effects of Ginkgo biloba on changes induced by quantitative cerebral microembolization in rats. Arch Int Pharmacodyn Ther 1980; 243 (2): 236–244.

    Google Scholar 

  173. Otamiri, T. and C. Tagesson. Ginkgo biloba extract prevents mucosal damage associated with small-intestinal ischaemia. Scand J Gastroenterol 1989; 24(6): 666–670.

    CAS  Google Scholar 

  174. Otani, M., S. S. Chatterjee, B. Gabard and G. W. Kreutzberg. Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema. Acta Neuropathol 1986; 69(1/2): 54–65.

    CAS  Google Scholar 

  175. Gautherie, M., P. Bourjat, E. Grosshans and Y. Quenneville. Vasodilator effects of Ginkgo biloba extract measured by thermometry and cutaneous thermography. Therapic 1972; 27(5): 881–892.

    CAS  Google Scholar 

  176. Jung, F., C. Mrowietz, H. Kiesewetter and E. Wenzel. Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers. Arzneim Forsch 1990; 40(5): 589–593.

    CAS  Google Scholar 

  177. Kang, S. S., J. S. Kim, W. J. Kwak and K. H. Kim. Identification and quantitative analysis of flavonol glycosides from Ginkgo biloba leaves by high performance liquid chromatography. Korean J Pharmacog 1990; 21 (2): 148–152.

    CAS  Google Scholar 

  178. Witte, S., I. Anadere and H. Chmiel. Therapeutical effect of Ginkgo biloba flavon glucosides on increased viscoelasticity of blood. Rev Port Hemorreol 1988; 2(1): 5–12.

    Google Scholar 

  179. Auguet, M., S. Delaflotte, A. Hellegouarch and F. Clostre. Pharmacological basis for the impact of Ginkgo biloba extract on vessels. La Presse Med 1986; 15(31): 1524–1528.

    CAS  Google Scholar 

  180. Ramassamy, C., F. Clostre, Y. Christen and J. Costentin. Prevention by a Ginkgo biloba extract (EGB 761) of the dopaminergic neurotoxicity of MPTP. J Pharm Pharmacol 1990; 42 (11): 785–789.

    CAS  Google Scholar 

  181. Winter, E. Effects of an extract of Ginkgo biloba on learning and memory in mice. Pharmacol Biochem Behav 1991; 38 (1): 109–114.

    CAS  Google Scholar 

  182. Kageyu, A., S. Nakagawa, T. Takigawa, M. Shimamura, M. Okada and M. Mizuno. Anti-inflammatory compositions containing dolichol. Patent-Japan Kokai Tokkyo Koho-62 33,118 1987; 11 pp.

    Google Scholar 

  183. Van Beek, T. A., H. A. Scheeren, T. Rantio, W. C. Melger and G. P. Lelyveld. Determination of ginkgolides and bilobalide in Ginkgo biloba leaves and phytopharmaceuticals. J Chromatogr 1991; 54(2): 375–387.

    Google Scholar 

  184. Rai, G. S., C. Shovlin and K. A. Wesnes. A double-blind, placebo controlled study of Ginkgo biloba extract (‘Tanakan’) in elderly out-patients with mild to moderate memory impairment. Curr Med Res Opin 1991; 12 (6) 350–355

    CAS  Google Scholar 

  185. Barth, S. A., G. Inselmann, R. Engemann and H. T. Heidemann. Influences of Ginkgo biloba on cyclosporin a induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and nacetylcysteine. Biochem Pharmacol 1991; 41(10): 1521–1526.

    CAS  Google Scholar 

  186. Song, Y. F. Chemical composition and utilization of Ginkgo biloba L. Lincoln Huaxue Yu Gongye 1986; 6(3): 42–45.

    CAS  Google Scholar 

  187. Lobstein, A., L. Rietsch-Jako, M. Haag-Berrurier and R. Anton. Seasonal variations of the flavonoid content from Ginkgo biloba leaves. Planta Med 1991; 57(5): 430–433.

    CAS  Google Scholar 

  188. Lacour, M., L. Ez-Zaher and J. Raymond. Plasticity mechanisms in vestibular compensation in the cat are improved by an extract of Ginkgo biloba (EGB 761). Pharm Biochem Behavior 1991; 40(2): 367–379.

    CAS  Google Scholar 

  189. Verotta, L., E. Lolla and A. Moggi. Improvement in the separation of two Ginkgo biloba coumaroyl flavonoids. Fitoterapia 1991; 62(4): 339–341.

    CAS  Google Scholar 

  190. Halama, P. Judgment of wellbeing and psychometric tests in patients from a neurological practice treated with ginkgo. Muench Med Wochenschr 1991; 133: S19–S22.

    Google Scholar 

  191. Jung, F., R. Schahram, H. Kiesewetter and E. Wenzel. Efficacy of Ginkgo biloba on cutaneous microcirculation. Muench Med Wochenschr 1991; 133: S44–S46.

    Google Scholar 

  192. Koza, K. D., F. D. Ernst and E. Spori. Retinal blood flow after Ginkgo biloba treatment in Fundus hypertonicus. Muench Med Wochenschr 1991; 133: 547–550.

    Google Scholar 

  193. Schmidt, U., K. Rabinovici and S. Lande. Effect of a Ginkgo biloba special extract on wellbeing in cerebral insufficiency. Muench Med Wochenschr 1991; 133: S15–S18.

    Google Scholar 

  194. Ramachandran, U., H. M. Divekar, S. K. Grover and K. K. Srivastava. New experimental model for the evaluation of adaptogenic products. J Ethnopharmacol 1990; 29(3): 275–281.

    CAS  Google Scholar 

  195. Warot, D., L. Lacomblez, Danjou, E. Weiller, C. Payan and A. J. Puech. Comparative effects of Ginkgo biloba extracts on psychomotor performances and memory in healthy volunteers. Therapie 1991; 46(1): 33–36.

    CAS  Google Scholar 

  196. Kang, S. S., J. S. Kim, W. J. Kwak and K. H. Kim. Flavonoids from the leaves of Ginkgo biloba. Korean J Pharmacog 1990; 21(2): 111–120.

    CAS  Google Scholar 

  197. Pietta, P., P. Mauri, A. Bruno, A. Rava, E. Manera and P. Ceva. Identification of flavonoids from Ginkgo biloba L., Anthemis nobilis L. and Equisetum arvense L. by high-performance liquid chromatography with diode-array UV detection. J Chromatogr 1991; 553(1/2): 223–231.

    CAS  Google Scholar 

  198. Koeltringer, P. Drug composition comprising ginkgo flavone glycosides for the treatment of neuropathies. Patent-Eur Pat Appl-326,034 1989; 5 pp.

    Google Scholar 

  199. Huguet, F. and T. Tarrade. Alpha 2-adrenoceptor changes during cerebral aging. The effect of Ginkgo biloba extract. J Pharm Pharmacol 1991; 44(1): 24–27.

    Google Scholar 

  200. Hofferberth, B. Ginkgo biloba special extract in patients with cerebro-organic syndrome. Muench Med Wochenschr 1991; 133: S30–S33.

    Google Scholar 

  201. Nieder, M. Pharmacokinetics of Ginkgo biloba flavonoids in plasma. Muench Med Wochenschr 1991; 133: S61–S62.

    Google Scholar 

  202. Allard, M. Treatment of old age disorders with Ginkgo biloba extract. Presse Medicale 1986; 15(31): 1540–1545.

    CAS  Google Scholar 

  203. Hartmann, A. and M. Frick. Efficacy of a ginkgo extract on psychometric parameters in patients with vascular dementia. Muench Med Wochenschr 1991; 133: S23–S25.

    Google Scholar 

  204. Schultz, H., M. Jobert and H. P. Breuel. Efficacy of L11370 concerning the egg of elderly persons in the enforced lack of sleep model. Muench Med Wochenschr 1991; 133: S26–S29.

    Google Scholar 

  205. Maier-Hauff, K. L11370 after cerebral aneurysm operation. Muench Med Wochenschr 1991; 133: S34–537.

    Google Scholar 

  206. Ernst, F. D. Effect of a Ginkgo biloba special extract on disturbed microcirculation. Muench Med Wochenschr 1991; 133: S51–S53.

    Google Scholar 

  207. Droy-Lefaix, M. T., B. Bonhomme and M. Doly. Protective effect of Ginkgo biloba extract (EGB 761) on free radical-induced changes in the electroretinogram of isolated rat retina. Drugs Exp Clin Res 1991; 17 (2): 571–574.

    CAS  Google Scholar 

  208. Dorman, D. C., L. M. Cote and W. B. Buck. Effects of an extract of Ginkgo biloba on bromethalin-induced cerebral lipid peroxidation and edema in rats. Amer J Vet Res 1992; 53(1): 138–142.

    CAS  Google Scholar 

  209. Matsumoto, T. Extraction of therapeutic flavons from ginkgo leaves. Patent-Japan Kokai Tokkyo Koho-02 193,907 1990; 3 pp.

    Google Scholar 

  210. Umeda, Y. Topical formulations containing flavonoids of gingkoleaf extracts. Patent-Japan Kokai Tokkyo Koho-04 29,934 1992; 4 pp.

    Google Scholar 

  211. Chung, A. S. and H. S. Shin. Studies on the lipid components of ginkgo nut. Han’guk Sikp’ um Kwahakhoe Chi 1978; 10: 119.

    CAS  Google Scholar 

  212. Ohmoto, T., T. Nikaido and M. Ikuse. Constituents of pollen. V. Constituents of Retula platyphylla var Japonica. Chem Pharm Bull 1978; 26: 1437–1442.

    CAS  Google Scholar 

  213. Kameyama, H. and C. Urakami. Glycolipids isolated from ginkgo nuts (Ginkgo biloba) and their fatty acid compositions. J Amer Oil Chem Soc 1979; 56: 549.

    CAS  Google Scholar 

  214. Geiger, H. 3′;-o-methylmyricetin-3-rhamnoglucoside a new flavonoid from the autumnal leaf of Ginkgo biloba L. Z Naturforsch Ser C 1979; 34: 878–879.

    Google Scholar 

  215. Joly, M., M. Haag-Berrurier and R. Anton. 5-Methoxybilobetin, a biflavone extracted from Ginkgo biloba. Phytochemistry 1980; 19: 1999–2002.

    CAS  Google Scholar 

  216. Ohmoto, T., O. Yoshida, M. Kano and M. Ikuse. Constituents of pollen. VII. Constituents of Ginkgo biloba L. Shoyakugaku Zasshi 1980; 34: 145–150.

    CAS  Google Scholar 

  217. Etienne, A., J. Baranes, F. Hecquet, A. Hellegouarch and F. Clostre. Membrane stabilizing effect of an extract of Ginkgo biloba. Planta Med 1980; 39: 237.

    Google Scholar 

  218. Chung, B. Y., L. S. Won, B. R. Lee and C. H. Lee. A new chemical constituent of green leaves of Ginkgo biloba. Taehan Hwahakhoe Chi 1982; 26: 95–98.

    CAS  Google Scholar 

  219. Hirao, N. and T. Shogaki. The essential oil of Ginkgo biloba L.(Icho). Kinki Daigaku Rikogakubu Kenkyu Hokoku 1981; 1981(16): 47–50.

    Google Scholar 

  220. Adawadkar, P. D. and M. A. El Sohly. Isolation, purification and antimicrobial activity of anacardic acids from Ginkgo biloba fruits. Fitoterapia 1981; 52: 129–135.

    CAS  Google Scholar 

  221. Kameyama, H. and K. Matsuoka. Steryl glycosides in ginkgo nuts (Ginkgo biloba). Kumamoto Joshi Diagaku Gakujutsu Kiyo 1983; 35: 69–72.

    CAS  Google Scholar 

  222. Bata, K., M. Mizuno, T. akugawa and Y. Tanaka. Long-chain betulaprenol-type polyprenols from the leaves of Ginkgo biloba. Biochem J 1983; 213(2): 305–311.

    Google Scholar 

  223. Briancon-Scheid, F., A. Lobstein-Guth and R. Anton. HPLC separation and quantitative determination of biflavones in leaves from Ginkgo biloba. Planta Med 1983; 49(4): 204–207.

    CAS  Google Scholar 

  224. Ishii, R., K. Yoshikawa, H. Minakata, H. Komura and T. Kada. Specificities of bio-antimutagens in plant kingdom. Agr Biol Chem 1984; 48(10): 2587–2591.

    Google Scholar 

  225. Woo, W. S., E. B. Lee, K. H. Shin, S. S. Kang and H. J. Chi. A review of research on plants for fertility regulation in Korea. Korean J Pharmacog 12(3): 153–170.

    Google Scholar 

  226. Hellegouarch, A., J. 1981; Baranes, F. Clostre, K. Drieu, P. Braquet and F. V. Defeudis. Comparison of the contractile effects of an extract of Ginkgo biloba and some neurotransmitters on rabbit isolated vena cava. Gen Pharmacol 1985; 16(2): 129–132

    CAS  Google Scholar 

  227. Bauer, U. 6-Month double-blind randomised clinical trial of Ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiency. Arzneim-Forsch 1984; 34(1): 716–720.

    CAS  Google Scholar 

  228. Osawa, T., H. Ishibashi, M. Namiki, T. Kada and K. Tsuji. Desmutagenic action of food components on mutagens formed by the sorbic acid nitrite reaction. Agr Biol Chem 1986; 50(8): 1971–1977.

    CAS  Google Scholar 

  229. Itokawa, H., N. Totsuka, K. Nakahara, K. Takeya, J. P. Lepoittevin and Y. Asakawa. Antitumor principles from Ginkgo biloba L. Chem Pharm Bull 1987; 35(7): 3016–3020.

    CAS  Google Scholar 

  230. Lamant, V., G. Mauco, P. Braquet, H. Chap and L. DousteBlazy. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol 1987; 36(17): 2749–2752.

    CAS  Google Scholar 

  231. Schaffler, K. and P. W. Reeh. Double-blind study of the hypoxia-protective effect of a standardized Ginkgo biloba preparation after repeated administration in healthy volunteers. Arzneim-Forsch 1985; 35(8): 1283–1286.

    CAS  Google Scholar 

  232. Namba, T., M. Tsunezuka, K. H. Bae and M. Hattori. Studies on dental caries prevention by traditional Chinese medicines. Part I. Screening of crude drugs for antibacterial action against Streptococcus mutans. Shoyakugaku Zasshi 1981; 35(4): 295–302.

    Google Scholar 

  233. Leifertova, I. and M. Lisa. The antifungal properties of higher plants affecting some species of the genus Aspergillus. Folia Pharm (Prague) 1979; 2: 29–54.

    CAS  Google Scholar 

  234. Koshimizu, K., H. Ohigashi, H. Tokuda, A. Kondo and K. Yamaguchi. Screening of edible plants against possible anti-tumor promoting activity. Cancer Lett 1988; 39(3): 247–257.

    CAS  Google Scholar 

  235. Duche, J. C., J. Barre, P. Guinot, J. Duchier, A. Cournot and J. P. Tillement. Effect of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. Pharmacol Res Commun 1988; 20(5): 349–368.

    Google Scholar 

  236. Hofferberth, B. Effect of Ginkgo biloba extract on neurophysiological and psychometric measurement results in patients with cerebro-organic syndrome/A double-blind study versus placebo. Arzneim-Forsch 1989; 39(8): 918–922.

    CAS  Google Scholar 

  237. Lee, E. B., H. S. Yun and W. S. Woo. Plants and animals used for fertility regulation in Korea. Korean J Pharmacog 1977; 8: 81–87.

    Google Scholar 

  238. Hoffmeister, H., G. Heinrich, G. B. Staal and W. J. Van Der Burg. The occurrence of ecdysterone in Taxus baccata. Naturwissenschaften 1967; 54: 471.

    CAS  Google Scholar 

  239. Sumi, M. The steroids isolated from several vegetables. Bull Inst Phys Chem Res 8: 228–233.

    Google Scholar 

  240. Dragendorff, G. Die 1929; Heilpflanzen der Verschiedenen Volker und Zeiten, F. Enke, Stuttgart, 1898; 885 pp.

    Google Scholar 

  241. Cross, F. B. The effect of certain cultural practices on the ascorbic acid content of some horticultural plants. Dissertation-Ph.D.-Univ Missouri 1939; 123 pp.

    Google Scholar 

  242. Ueki, H., M. Kaibara, M. Sakagawa and S. Hayashi. Antitumor activity of plant constituents. I. Yakugaku Zasshi 1961; 81: 1641–1644.

    CAS  Google Scholar 

  243. Heal, R. E., E. F. Rogers, R. T. Wallace and O. Starnes. A survey of plants for insecticidal activity. Lloydia 1950; 13: 89–162.

    Google Scholar 

  244. Datko, A. H., S. H. Mudd and J. Giovanelli. A sensitive and specific assay for cystathionine: Cystathionine content of several plant tissues. Anal Biochem 1974; 62 (2): 531–545.

    CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ross, I.A. (2001). Ginkgo biloba. In: Medicinal Plants of the World. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-237-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-237-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9706-9

  • Online ISBN: 978-1-59259-237-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Navigation