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Reactive Oxygen Species in Proliferative Signaling

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Signaling Networks and Cell Cycle Control

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

The traditional view of reactive oxygen species (ROS), such as H2O2 and superoxide (O2 −), as toxic byproducts of aerobic metabolism, and their use as antimicrobial agents by the immune system, might make the notion that ROS can act as positive regulators of cell proliferation somewhat counterintuitive. Nonetheless, evidence has accumulated over the past 10 years that strongly supports ROS regulation of a variety of cellular processes, including proliferation. The picture that has emerged indicates that ROS are previously unappreciated components of established regulatory pathways. More specifically, it appears that ROS act as messengers in signal transduction pathways (1).

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Authors
  1. Toren Finkel MD, PhD
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  2. Daniel M. Sullivan PhD
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Editors and Affiliations

  1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    J. Silvio Gutkind PhD

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© 2000 Humana Press Inc., Totowa, NJ

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Finkel, T., Sullivan, D.M. (2000). Reactive Oxygen Species in Proliferative Signaling. In: Gutkind, J.S. (eds) Signaling Networks and Cell Cycle Control. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-218-0_19

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  • DOI: https://doi.org/10.1007/978-1-59259-218-0_19

  • Publisher Name: Humana Press, Totowa, NJ

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