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Frequency of the Delta-F508 Mutation and Flanking Marker Haplotypes at the Cystic Fibrosis Locus from 167 Czech Families

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The Identification of the CF (Cystic Fibrosis) Gene

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 290))

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Abstract

This study was undertaken in order to compare the predominantly Slavic Czech Cystic Fibrosis (CF) population of Bohemia and Moravia (Czech Republic of Czechoslovakia) with other Caucasian populations in Europe for the deltaF508 CFTR gene mutation (Kerem et al., 1989) and CF-linked marker loci MET, D7S23, D7S399 and D7S8. This geographical region was a crossroad of Central Europe, where in particular Slavic and German groups came into close contact. It was to be expected that deltaF508 and CF-linked haplotype frequencies would reflect the population history of this region.

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References

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Faculty of Medicine, Charles University, Prague, Czechoslovakia

    M. Macek Jr.

  2. Institute of Human Genetics, Free University Berlin (West), D1000, Heubnerweg 6, Berlin 19, Germany

    M. Macek Jr., I. Boehm, M. Stuhrmann, A. Reis, K. Sperling & J. Schmidtke

  3. Institute for Child Development Research, Pediatric Faculty, Charles University, Prague, Czechoslovakia

    V. Vavrova & M. Macek

  4. Institute of Human Genetics, Göttingen University, Federal Republic of Germany

    M. Krawczak

  5. Center of Medical Genetics, Pediatric Faculty, Charles University, Prague, Czechoslovakia

    R. Duspisova & E. Jelinkova

  6. Genetic Laboratory of Dr. Waldenmaier, Munich, Federal Republic of Germany

    I. Boehm

Authors
  1. M. Macek Jr.
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  2. V. Vavrova
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  3. I. Boehm
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  4. M. Stuhrmann
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  5. A. Reis
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  6. M. Macek
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  7. R. Duspisova
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  8. E. Jelinkova
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  9. K. Sperling
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  10. M. Krawczak
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  11. J. Schmidtke
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Editor information

Editors and Affiliations

  1. The Hospital for Sick Children, Toronto, Ontario, Canada

    Lap-Chee Tsui

  2. Istituto Giannina Gaslini, Genoa, Italy

    Giovanni Romeo

  3. Albert-Ludwigs-Universität, Freiburg, Germany

    Rainer Greger

  4. Fondazione Internazionale Menarini, Florence, Italy

    Sergio Gorini

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© 1991 Springer Science+Business Media New York

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Macek, M. et al. (1991). Frequency of the Delta-F508 Mutation and Flanking Marker Haplotypes at the Cystic Fibrosis Locus from 167 Czech Families. In: Tsui, LC., Romeo, G., Greger, R., Gorini, S. (eds) The Identification of the CF (Cystic Fibrosis) Gene. Advances in Experimental Medicine and Biology, vol 290. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5934-0_42

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  • DOI: https://doi.org/10.1007/978-1-4684-5934-0_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5936-4

  • Online ISBN: 978-1-4684-5934-0

  • eBook Packages: Springer Book Archive

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