Abstract
The interaction of proteins with various types of polyelectrolytes occurs commonly in nature. in the case of enzymes, the interaction may be quite specific with regard to the nature of the polyelectrolyte. the addition of the polyelectrolyte to an enzyme may result in either an increase in enzyme activity or an inhibition of activity depending on the enzyme in question. Thus, polyanions such as polynucleotides, or sulfated glycoaminoglycans like heparin and chondroitin sulfate, may be activators of some enzymes but are inhibitors of others. A similar situation apparently applies to polycations such as polylysine or polyornithine. There are apparently two important requirements for these polyelectrolytes to be enzyme effectors: 1) the macromolecular nature of the polyelectrolyte and 2) the presence of strong positive or negative charges (1).
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Elbein, A.D., Pan, Y.T. (1977). Protein: Polyanion Interactions. Studies on the Trehalose-P Synthetase as a Model System. In: Friedman, M. (eds) Protein Crosslinking. Advances in Experimental Medicine and Biology, vol 86A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3282-4_24
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DOI: https://doi.org/10.1007/978-1-4684-3282-4_24
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