Abstract
As a result of intense interest, supported by many clinical examples, a large body of knowledge concerning the interactions of drugs is being assembled which has very practical impacts on patient care. In part, such information has been abetted by the rapidly evolving methodology utilized by the clinical pharmacologist in studies on drug absorption, metabolism, and excretion. It has also received impetus from the increasing appreciation of the frequency of iatrogenically, drug-induced diseases in clinical practice. Thus, when one considers the essentiality of dietary nutrients for the innumerable and complex physiologic functions of the body, in both the healthy and the diseased state, including those specifically related to drug metabolism, it is not surprising that considerable interest has developed in drug-nutrient interrelationships. This has been evidenced by several recent symposia, review articles, and books (Miller, 1976; Roe, 1976; Hartshorn, 1977; Hathcock and Coon, 1978).
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References
Akhtar, A. J., Crompton, G. K., and Schonell, M. E., 1968, para-Aminosalicylic acid as a cause of intestinal malabsorption, Tubercle 49: 328.
Alvares, A. P., Anderson, K. F., Conney, A. H., and Kappas, A., 1976, Interactions between nutritional factors and drug biotransformations in man, Proc. Natl. Acad. Sci. U.S.A 73: 2501.
Basu, T. K., and Dickerson, J. W. T., 1974, Inter-relationships of nutrition and the metabolism of drugs, Chem. Biol. Interact 8: 193.
Basu, T. K., Dickerson, J. W. T., and Parke, D. F., 1971, Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver, Biochem. J 124: 19.
Basu, T. K., Dickerson, J. W. T., and Parke, D. F., 1973, Effect of underfeeding suckling rats on the activity of hepatic drug metabolizing enzymes, Biol. Neonate 23: 109.
Baugh, C. M., and Krumdieck, C. L., 1969, Effects of phenytoin on folic-acid conjugases in man, Lancet 2: 519.
Becking, G. C., 1972, Influence of dietary iron levels on hepatic drug metabolism in vivo and in vitro in the rat, Biochem. Pharmacol 21: 1585.
Becking, G. C., 1976a, Hepatic drug metabolism in iron-, magnesium-and potassium-deficient rats, Fed. Proc. Fed. Am. Soc. Exp. Biol 35: 2480.
Becking, G. C., 1976b, Trace elements and drug metabolism, Med. Clin. North Am. 60: 813.
Becking, G. C., and Morrison, A. B., 1970a, Hepatic drug metabolism in zinc-deficient rats, Biochem. Pharmacol 19: 895.
Becking. G. C., and Morrison, A. B., 1970b, Role of dietary magnesium in the metabolism of drugs by NADPH-dependent rat liver microsomal enzymes, Biochem. Pharmacol 19: 2639.
Bernstein, L. H., Gutstein, S., Weiner, S., and Efron, G., 1970, The absorption and malabsorption of folic acid and its polyglutamates, Am. J. Med 48: 570.
Borgstedt, A. D., Bryson, M. F., Young, L. W., and Forbes, G. B., 1972, Long-term administration of antiepileptic drugs and the development of rickets, J. Pediatr 81: 9.
Caasi, P. I., Hauswirth, J. W., and Nair, P. P., 1972, Biosynthesis of heme in vitamin E deficiency, Ann. N.Y. Acad. Sci 203: 93.
Campbell, T. C., and Hayes, J. R., 1974, Role of nutrition in drug-metabolizing enzyme system, Pharmacol. Rev 26: 171.
Campbell, T. C., and Hayes, J. R., 1976, The effect of quantity and quality of dietary protein on drug metabolism, Fed Proc. Fed. Am. Soc. Exp. Biol 35: 2470.
Carpenter, M. P., 1971, The lipid composition of maturing rat testis. The effect of alpha-tocopherol, Biochim. Biophys. Acta 231: 52.
Carpenter, M. P., 1972, Vitamin E and microsomal drug hydroxylations, Ann. N.Y. Acad. Sci 203: 81.
Catz, C. S., Juchau, M. R., and Yaffe, S. J., 1970, Effects of iron, riboflavin and iodide deficiencies
Catz, C. S., Juchau, M. R., and Yaffe, S. J., 1970, On hepatic drug metabolizing enzyme systems, J. Pharmacol. Exp. Ther 174: 197.
Conney, A. H., Bray, G. A., Evans, C., and Burns, J. J., 1961, Metabolic interactions between L-ascorbic acid and drugs, Ann. N.Y. Acad. Sci 92: 115.
Cotzias, G. C., 1969, Metabolic modifications of some neurologic disorders, J. Am. Med. Assoc 210: 1255.
Crounes, R. G., 1963, Effective use of griseofulvin, Arch. Dermatol 87: 176.
Dent, C. E., Richens, A., Rowe, D. J. F., and Stamp, T. C. B., 1970, Osteomalacia with longterm anticonvulsant therapy in epilepsy, Br. Med. J 4: 69.
Dingell, J. V., Joiner, P. D., and Hurwitz, L., 1966, Impairment of hepatic drug metabolism in calcium deficiency, Biochem. Pharmacol 15: 971.
Diplock, A. T., 1974, Possible stabilizing effect of vitamin E on microsomal membrane-bound, selenide-containing proteins and drug metabolizing enzyme systems, Am. J. Clin. Nutr 27: 995.
Diplock, A. T. Baum, H., and Lucy, J. A., 1971, The effect of vitamin E on the oxidation state of selenium in rat liver, Biochem. J 123: 721.
Dixon, R. L., Shultice, R. W., and Fouts, J. R., 1960, Factors affecting drug metabolism by liver microsomes, IV. Starvation, Proc. Soc. Exp. Biol. Med 103: 333.
Dobbins, W. O., III, Herrero, B. A., and Mansbach, C. M., 1968, Morphologic alterations associated with neomycin induced malabsorption, Am. J. Med. Sci 255: 63.
Faloon, W. W., 1970, Drug production of intestinal malabsorption, N.Y. State J. Med 70: 2189.
Fawcett, D. W., 1955, Observations on cytology and electron microscopy of hepatic cells, J. Natl. Cancer Inst 15: 1475.
Feingold, D. S., and Davis, B. D., 1962, Paradoxical effect of streptomycin, kanamycin and neomycin on Escherichia coli ribonucleic acid, Biochem, Biophys. Acta 55: 787.
Fouts, J. R., and Pohl, R. J., 1971, Further studies on the effects of metal ions on rat liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase, J. Pharmacol. Exp. Ther 179: 91.
Franke, D. E., and Whitney H. A. K. (eds)., 1972, Perspectives in Clinical Pharmacy, Drug Intelligence Publications, Hamilton, Illinois.
Frieden, E., 1973, The ferrous to ferric cycles in iron metabolism, Nutr. Rev 31: 41.
Fumer, R. L., and Feller, D. D., 1971, The influence of starvation upon hepatic drug metabolism in rats, mice, and guinea pigs, Proc. Soc. Exp. Biol. Med 137: 816.
Gillette, J. R., 1971, Factors affecting drug metabolism, Ann. N.Y. Acad. Sci 179: 43.
Hanlon, D. P., 1975, Interaction of thiamazole with zinc and copper, Lancet 1: 929.
Hartshorn, E. A., 1977, Food and drug interactions, J. Am. Diet. Assoc 70: 15.
Hathcock, J. N., and Coon, J. (eds.), 1978, Nutrition and Drug Interrelations, Academic Press, New York.
Hawkins, C. F., and Meynell, M. J., 1954, Megaloblastic anaemia due to phenytoin sodium, Lancet 2: 737.
Hoffbrand, A. V., and Necheles, T. F., 1968, Mechanism of folate deficiency in patients receiving phenytoin, Lancet 2: 528.
Hunter, J., Maxwell, J. D., Stewart, D. A., Parsons, V., and Williams, R., 1971, Altered calcium metabolism in epileptic children on anticonvulsants, Br. Med. J 4: 202.
Jacobson, E. D., Chodos, R. B., and Faloon, W. W., 1960a, An experimental malabsorption syndrome induced by neomycin, Am. J. Med 28: 524.
Jacobson, E. D., Prior, J. T., and Faloon, W. W., 1960b, Malabsorptive syndrome induced by neomycin: Morphologic alterations in the jejunal mucosa, J. Lab. Clin. Med 56: 245.
Jones, A. L., and Fawcett, D. W., 1965, Hypertrophy of the agranular endoplasmic reticulum in hamster liver induced by phenobarbital (with a review of the function of this organelle in liver), J. Histochem. Cytochem 14: 215.
Kato, R., and Gillette, J. R., 1965, Effect of starvation on NADPH-dependent enzymes in liver microsomes of male and female rats, J. Pharmacol. Exp. Ther 150: 279.
Kato, R., and Takanaka, A., 1968, Effect of phenobarbital on electron transport system, oxidation and reductions of drugs in liver microsomes of rats of different age, J. Biochem 63: 406.
Kendall, M. J., and Chan, K., 1973, Drug-induced malabsorption, Xenobiotica 3: 727.
Keusch, G. T., Buchanan, R. D., Bhamarapravathi, N., and Troncale, F. J., 1967, Neomycin enteropathy in man, Clin. Res 15: 237.
Klein, J. O., and Finland, M., 1963, Nafcillin. Anti-bacterial action in vitro and absorption and excretion in normal young men, Am. J. Med. Sci 246: 10.
Kunin, C. M., and Finland, M., 1961, Clinical pharmacology of the tetracycline antibiotics, Clin. Pharmacol. Ther 2: 51.
Lambert, M. L., Jr., 1975, Drug and diet interactions, Am. J. Nurs 75: 402.
Leon, S. A., and Brock, T. D., 1967, Effect of streptomycin and neomycin on physical properties of the ribosome, J. Mol. Biol 24: 391.
Lu, A. Y., 1976, Liver microsomal drug-metabolizing enzyme system: Functional components and their properties. Fed. Proc. Fed. Am. Soc. Exp. Biol 35: 2460.
Lu, A. Y., Junk, K. W., and Coon, M. J., 1969, Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components, J. Biol. Chem 244: 3714.
Luft, D. Degkwitz, E., Höchli-Kaufmann, L., and Staudinger, H., 1972, Einfluss von DeltaAminolävulinsäure auf den Gehalt and Cytochrom P-450 in der Leber ascorbinsäure-fei ernährter Meerschweinchen, Hoppe-Seyler’s Z. Physiol. Chem 353: 1420.
Mannheimer, E., Pakesch, F., Reimer, E. F., and Vetter, H., 1952, Die Hämatologischen Komplikationen der Epilepsie-Behandlung mit Hydantoinkörpern, Med. Klin. (Munich) 47: 1397.
Miller, O. N. (chairman), 1976, Symposium on Nutrition and Drug Metabolism, Fed. Proc. Fed. Am. Soc. Exp. Biol 35: 2459.
O’Malley, K., ana Stevenson, I. H., 1973, Iron deficiency anaemia and drug metabolism, J. Pharm. Pharmacol 25: 339.
Paes, I. C., Searl, P., Rupert, M. W., and Faloon, W. W., 1967, Intestinal lactase deficiency and saccharide malabsorption during oral neomycin administration, Gastroenterology 53: 49.
Patel, J. M., and Pawar, S. S., 1973, Effect of riboflavin deficiency on liver microsomal enzyme system and lipid peroxidation in male rats, Indian J. Biochem. Biophys 10: 73.
Patel, J. M., and Pawar S. S., 1974, Riboflavin and drug metabolism in adult male and female rats, Biochem. Pharmacol 23: 1467.
Pécoud, A., Donzel, P., Schelling, J. L., 1975, Effect of foodstuffs on the absorption of zinc sulfate, Clin. Pharmacol. Ther 17: 469.
Race, T. F., Paes, I. C. and Faloon, W. W., 1970, Intestinal malabsorption induced by oral colchicine. Comparison with neomycin and cathartic agents, Am. J. Med. Sci 259: 32.
Reidenberg, M. M., and Vesell, E. S., 1975, Unaltered metabolism of antipyrine and tolbutamide in fasting man, Clin. Pharmacol. Ther 17: 650.
Reidenberg, M. M., Kostenbauder, H., and Adams, W. P., 1969, Rate of drug metabolism in obese volunteers before and during starvation and in azotemic patients, Metabolism 18: 209.
Reidenberg, M. M., James, M., and Dring, L. G., 1972, The rate of procaine hydrolysis in serum of normal subjects and diseased patients, Clin. Pharmacol. Ther 13: 279.
Roe, D. A., 1976, Drug-Induced Nutritional Deficiencies, AVI Publications, Westport, Connecticut.
Roels, O. A., 1967, Effect of nutrition and stress upon the metabolism of some barbiturate anesthetics, Nutr. Rev 25: 51.
Rosenberg, I. H., 1972, Drugs and folic acid absorption, Gastroenterology 63: 353.
Rosenberg, I. H., Godwin, H. A., Streiff, R. R., and Castle, W. B., 1968, Impairment of intestinal deconjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy, Lancet 2: 530.
Strobel, H. W., Lu, A. Y., Heidema, J., and Coon, M. J., 1970, Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation, J. Biol. Chem 245: 4851.
Tandler, B., Erlandson, R. A., and Wynder, E. L., 1968, Riboflavin and mouse hepatic cell structure and function. I. Ultrastructural alterations in simple deficiency, Am. J. Pathol 52: 69.
Thompson, G. R., Barrowman, J., Gutierrez, L., and Dowling, R. H., 1971, Action of neomycin on the intraluminal phase of lipid absorption, J. Clin. Invest 50: 319.
Tomkin, G. H., Hadden, D. R., Weaver, J. A., and Montgomery, D. A. D., 1971, Vitamin B12 status of patients on long-term metformin therapy, Br. Med. J 2: 685.
Vilter, R. W., 1964, The vitamin B6-hydrazide relationship, in: International Symposium on Vitamin B 6 , Vol. 22 ( R. S. Harris, I. G. Wool, and J. A. Loraine, eds.), pp. 797–805, Academic Press, New York.
Wade, A. E., and Norred, W. P., 1976, Effect of dietary lipid on drug-metabolizing enzymes, Fed. Proc. Fed. Am. Soc. Exp. Biol 35: 2475.
Welling, P. G., Lyons, L. L., Craig, W. A., and Trochta, G. A., 1975, Influence of diet and fluid on bioavailability of theophylline, Clin. Pharmacol. Ther 17: 475.
Zannoni, V. G., and Sato, P. H., 1976, The effect of certain vitamin deficiencies on hepatic drug metabolism, Fed. Proc. Fed. Am. Soc. Exp. Biol 35: 2464.
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Mueller, J.F. (1980). Drug-Nutrient Interrelationships. In: Alfin-Slater, R.B., Kritchevsky, D. (eds) Nutrition and the Adult. Human Nutrition, vol 3B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7216-9_9
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