• 93 Accesses

Abstract

Lipids, as a broad category of cellular constituents such as carbohydrates, proteins, vitamins, hormones, and minerals, play varied and assorted roles in living organisms. Some fatty acids are used as energy sources and energy reserves—the triglycerides in adipose tissue represent the energy reserves storing fatty acids as esters and the brown adipose tissue functions to maintain body temperature. Other fatty acids are combined in covalent bonds in complex compounds which form much of the lipid portions of cellular and organelle membranes. Finally, the third major function of lipids is to provide structural elements of which myelin of nerve tissue is an excellent example. In addition, certain lipids may be viewed as vitamins (vitamins A, D, E, and essential polyunsaturated fatty acids) and as hormones (the prostaglandins, steroids, etc.).

This work was supported in part by the U.S. Public Health Service Grant NB-01575–12.

This article is not intended to be a complete review of the literature. Rather, it is an overview of the complex problem of lipid anabolism and catabolism, precursor pools and product pools, the blood-brain barrier, and their relationship to lipid turnover. Lipid turnover is reported as half-life time (<Inline>1</Inline>). The theoretical points are illustrated by selected, but not comprehensive, data from the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 42.79
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 53.49
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. R. M. Burton (ed.), Lipid Monolayer and Bilayer Models and Cellular Membranes, The American Oil Chemists’ Society, Chicago, Illinois (1967).

    Google Scholar 

  2. R. M. Burton, in Drugs and Poisons in Relation to the Develo** Nervous System (G. M. McKhann and S. J. Yaffe, eds.) pp. 60–75, Public Health Service Publication 1791, Bethesda, Md. (1967).

    Google Scholar 

  3. R. M. Burton, M. A. Sodd, and R. O. Brady, The incorporation of galactose into galactolipids, J. Biol. Chem. 233:1053–1060 (1958).

    PubMed  CAS  Google Scholar 

  4. A. K. Hajra and N. S. Radin, Isotopic studies of the biosynthesis of cerebroside fatty acids in rats, J. Lipid Res. 4:270–278 (1963).

    PubMed  CAS  Google Scholar 

  5. Y. Kishmoto, B. W. Agranoff, M. S. Radin, and R. M. Burton, Comparison of the lipids and fatty acids of subcellular brain fractions, J. Neurochem. (in press).

    Google Scholar 

  6. S. Handa and T. Yamakawa, Chemistry of lipids of posthemolytic residue or stroma of erythrocytes. XII. Chemical structure and chromatographic behavior of hematosides obtained from equine and dog erythrocytes, Jap. J. Exptl. Med., 5, Vol. 34, 293–304 (1964).

    Google Scholar 

  7. E. Klenk, in Biochemistry of the Develo** Nervous System (H. Waelsch, ed.) Academic Press, pp. 397–410, New York (1955).

    Google Scholar 

  8. L. A. Cuzner, A. N. Davison, and N. A. Gregson, Chemical and metabolic studies of rat myelin of the central nervous system in research in demyelinating diseases, Ann. N. Y. Acad. Sci. 122:86–92 (1965).

    Article  PubMed  CAS  Google Scholar 

  9. G. Bartsch, Incorporation of acetate-1-C14 into the sphingolipids of the rat brain, VI Int. Congress of Biochem., (1964), p. 564.

    Google Scholar 

  10. R. M. Burton and J. M. Gibbons, Ganglioside and cerebroside turnover rates in rat brain, Fed. Proc. 23:230 (1964).

    Google Scholar 

  11. S. J. Wakil, in Ann. Biochem. (J. M. Luck, ed.) pp. 369–406, Annual Reviews Inc., Palo Alto (1962).

    Google Scholar 

  12. M. E. Smith and L. F. Eng, The turnover of the lipid components of myelin, J. Am. Oil Chem. Soc. 42:1013–1018 (1965).

    Article  PubMed  CAS  Google Scholar 

  13. M. L. Cuzner, A. N. Davison, and N. A. Gregson, Turnover of brain mitochondrial membrane lipids, Biochem. J. 101:618–626 (1966).

    PubMed  CAS  Google Scholar 

  14. R. O. Brady and G. J. Koval, The enzymatic synthesis of sphingosine, J. Biol. Chem. 233: 26–31 (1958).

    PubMed  CAS  Google Scholar 

  15. A. N. Davison and M. Wajda, Metabolism of myelin lipids: estimation and separation of brain lipids in the develo** rabbit, J. Neurochem. 4:353–359 (1959).

    Article  PubMed  CAS  Google Scholar 

  16. R. M. Burton, in Lipids and Lipidoses (G. Schettler, ed.) pp. 122–167, Springer-Verlag, New York (1967).

    Chapter  Google Scholar 

  17. N. S. Radin, F. B. Martin, and J. R. Brown, Galactolipide Metabolism, J. Biol. Chem. 224:499–507 (1957).

    PubMed  CAS  Google Scholar 

  18. R. M. Burton, S. Handa, R. E. Howard, and T. Vietti, Incorporation of Selected Isotopes into Lipids of Humans with Cerebral Lipidoses: Studies on D-glucosamine-l-14C, Path. Europ. 3:424–430 (1968).

    CAS  Google Scholar 

  19. K. Suzuki, Formation and turnover of the major brain gangliosides during development, J. Neurochem. 14:917–925 (1967).

    Article  PubMed  CAS  Google Scholar 

  20. T. Taketomi and T. Yamakawa, Further confirmation on the structure of brain cerebro-side sulfuric ester, J. Biochem. (Tokyo) 55:87–89 (1964).

    CAS  Google Scholar 

  21. P. Stoffyn and A. Stoffyn, Structure of sulfatides, Biochim. Biophys. Acta 70:218–220 (1963).

    Article  PubMed  CAS  Google Scholar 

  22. J. P. Green and J. D. Robinson, Jr., Cerebroside sulfate (sulfatide A) in some organs of the rat and in the mast cell tumor, J. Biol. Chem. 235:1621–1623 (1960).

    PubMed  CAS  Google Scholar 

  23. A. N. Davison and N. A. Gregson, The physiological role of cerebron sulphuric acid (sulpha-tide in the brain), Biochem. J. 85:558–568 (1962).

    PubMed  CAS  Google Scholar 

  24. A. N. Davison and N. A. Gregson, Metabolism of cellular membrane sulpholipids in rat brain, Biochem. J. 98:915–922 (1966).

    PubMed  CAS  Google Scholar 

  25. A. N. Davison and J. Dobbing, Phospholipid metabolism in nervous tissue. I. A reconsideration of brain and peripheral-nerve phospholipid metabolism in vivo, Biochem. J. 73:701–706 (1959).

    PubMed  CAS  Google Scholar 

  26. G. B. Ansell and S. Spanner, Incorporation of orthophosphate labeled with phosphorus-32 into cerebral phospholipids in vivo, Nature 185:826–828 (1960).

    Article  PubMed  CAS  Google Scholar 

  27. G. B. Ansell and T. Chojnacki, The fate of radioactive phospholipid precursors injected into the subarachnoid space of the rat, Biochim. Biophys. Acta Library 1:425–432 (1963).

    Google Scholar 

  28. M. R. Hokin, L. E. Hokin, and W. D. Shelp, The effects of acetylcholine on the turnover of phosphatic acid and phosphoinositide in sympathetic ganglia, and in various parts of the central nervous system in vitro, J. Gen. Physiol. 44:217–226 (1960).

    Article  PubMed  CAS  Google Scholar 

  29. M. R. Hokin, Effect of norepinephrine on 32P incorporation into individual phosphatides in slices from different areas of the guinea pig brain, J. Neurochem. 16:127–134 (1969).

    Article  PubMed  CAS  Google Scholar 

  30. M. G. Larrabee, Transynaptic stimulation of phosphatidylinoside metabolism in sympathetic neurons in situ, J. Neurochem. 15:803–808 (1968).

    Article  PubMed  CAS  Google Scholar 

  31. A. A. Khan and J. Folch-Pi, Cholesterol turnover in brain subcellular particles, J. Neurochem. 14:1099–1105 (1967).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Burton, R.M. (1971). The Turnover of Lipids. In: Metabolic Turnover in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7166-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7166-7_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7168-1

  • Online ISBN: 978-1-4615-7166-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Navigation