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Structure Determination via Complete Relaxation Matrix Analysis (CORMA) of Two-Dimensional Nuclear Overhauser Effect Spectra

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Biological Magnetic Resonance

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 9))

Abstract

Methods for the complete high-resolution determination of molecular structure in solution have been a goal of scientists since the development of X-ray diffraction techniques in the early part of this century. Methods that yield at least a part of the structural picture include hydrodynamic techniques, electron diffraction and other scattering techniques, circular dichroism, fluorescence decay, extended X-ray absorption fine structure, and magnetic resonance. The information obtainable from these methods ranges from rough estimates of the overall shape and dimension of a molecule to a gauge of the extent of secondary structure (local conformational properties such as α-helix and β-sheet). At best it is possible to obtain a measure of some of the distances within the molecule. However, with the possible exception of nuclear magnetic resonance, a high-resolution structural model is not yet attainable with any of these methods.

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Authors and Affiliations

  1. Cray Research, Inc., San Ramon, California, 94583, USA

    Brandan A. Borgias

  2. Department of Pharmaceutical Chemistry, University of California, San Francisco, California, 94143, USA

    Thomas L. James

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  1. Brandan A. Borgias
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  2. Thomas L. James
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Editors and Affiliations

  1. Ohio State University, Columbus, Ohio, USA

    Lawrence J. Berliner

  2. Hercules Incorporated, Research Center, Wilmington, Delaware, USA

    Jacques Reuben

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© 1990 Plenum Press, New York

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Borgias, B.A., James, T.L. (1990). Structure Determination via Complete Relaxation Matrix Analysis (CORMA) of Two-Dimensional Nuclear Overhauser Effect Spectra. In: Berliner, L.J., Reuben, J. (eds) Biological Magnetic Resonance. Biological Magnetic Resonance, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6549-9_3

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  • DOI: https://doi.org/10.1007/978-1-4615-6549-9_3

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