Abstract
CD8+ T cells are normally less numerous than CD4+ T cells in uninfected individuals. Virus infections can result in an especially intense activation of CD8+ T cells1–5 and there are large increases in the number of circulating CD8+ T cells in humans infected with cytomegalovirus, Epstein-Barr Virus, or Varicella-Zoster Virus.1,3,4 In mice infected with LCMV there is an approximately 5-fold increase in the number of CD8+ T cells.6 As the total number of CD8+ cells expands, limiting dilution analysis (LDA) reveals that the number of virus specific CTL also increases.5–8 However, LDA indicates that the number of virus-specific CD8+ T cells is small, 1/4000-1/50 depending upon the virus.5–8 The specificities of the rest of the expanding CD8+ T cells has not been determined, though it has been shown that during LCMV infection there is an increase in non-LCMV reactive CTL that are alloreactive and antigen crossreactive CTL.9,10 Furthermore, there are not only more CD8+ T cells during the immune response to LCMV, but most of them appear to have been activated as they are enlarged, have elevated surface expression of CD11a, CD11b, CD44, CD49d, IL-2R and reduced expression of CD62L.11–13
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Butz, E., Bevan, M.J. (1998). Dynamics of the CD8+ T Cell Response during Acute LCMV Infection. In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7_13
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DOI: https://doi.org/10.1007/978-1-4615-5355-7_13
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