Abstract
Intracellular bacteria and protozoa typically stimulate host responses dominated by Type 1 cytokine production and cell-mediated immune effector functions. While the probable role of these responses is to limit growth of the infecting pathogen, the basis of their preferential induction is poorly understood and poses a fundamental question in immunologic class selection(1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 383:787–93, 1996.
Frenkel JK: Pathophysiology of toxoplasmosis. Parasitology Today 4:273–278, 1988.
Sher A, Denkers EY, Gazzinelli RT: Induction and regulation of host cell-mediated immunity by Toxoplasma gondii. Ciba Found Symp 195:95–104, 1995.
Suzuki Y, Conley FK, Remington JS: Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J Immunol 143:2045–2050, 1989.
Suzuki Y, Orellana MA, Schreiber RD, Remington JS: Interferon-γ:The major mediator of resistance against Toxoplasma gondii. Science 516:240–518, 1988.
Hunter CA, Subauste CS, Van Cleave VH, Remington JS: Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect Immun 62:2818–24, 1994.
Gazzinelli RT, Wysocka M, Hayashi S, Denkers EY, Hieny S. Caspar P, Trinchieri G, Sher A: Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 153:2533–43, 1994.
Gazzinelli RT, Hieny S, Wynn T, Wolf S, Sher A: IL-12 is required for the T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc Nat Acad Sci, USA 90:6115–6119, 1993.
Khan IA, Matsuura T, Kasper LH: Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect Immun 62:1639–42, 1994.
Scharton-Kersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A: In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol 157:4045–54, 1996.
Locksley RM: Interleukin 12 in host defense against microbial pathogens. Proc Natl Acad Sci, USA 90:5879–5880, 1993.
Hsieh CS, Macatonia SE, Tripp CS, Wolf S, O’garra A, Murphy KM: Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547, 1993.
Grunvald E, Chiaramonte M, Hieny S, Wysocka M, Trinchieri G, Vogel SN, Gazzinelli RT, Sher A: Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii. Infect Immun 64:2010–8, 1996.
Reis e Sousa C, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A.: In vivo microbial stimulation induces rapid CD40 ligand-independent production of Interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med 186:1831–1841, 1997.
Inaba K, Pack M, Inaba M, Sakuta H, Isdell F, Steinman RM: High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes. J Exp Med 186:665–672, 1997.
Vremec D, Shortman K: Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J Immunol 159:565–573, 1997.
De Smedt T, Pajak B, Muraille E, Lespagnard L, Heinen E, De Baetselier P, Urbain J, Leo O, Moser M: Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 184:1413–24, 1996.
Steinman RM: The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 9:271–296, 1991.
Austyn JM: New insights into the mobilization and phagocytic activity of dendritic cells. J Exp Med 183:1287–92, 1996.
Roake JA, Rao AS, Morris PJ, Larsen CP, Hankins DF, Austyn J M: Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 181:2237–47, 1995.
MacPherson GG, Jenkins CD, Stein MJ, Edwards C: Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence. J Immunol 154:1317–22, 1995.
Gorak PMA, Engwerda CR, Kaye PM: Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur J Immunol, In press, 1998.
Johnson LL, Sayles PC: Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii. J Exp Med 186:1799–802, 1997.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sher, A. et al. (1998). The Role of Dendritic Cells in the Initiation of Host Resistance to Toxoplasma Gondii . In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7_12
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5355-7_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7443-5
Online ISBN: 978-1-4615-5355-7
eBook Packages: Springer Book Archive