Abstract
Cerebral blood volume (CBV) can be quantified by both near infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI). The aim is to compare CBV results obtained by NIRS and MRI in adult patients.
10 adult patients, 6 females and 4 males, age median 24 (range 21 to 76) years, were included in this study. All needed a MRI investigation with contrast medium for clinical reasons.
The NIRS instrument, the Cerebral RedOx Monitor 2020 from Critikon, quantifies cerebral haemoglobin concentration using a sensor with two receiving channels at different distances. Geometrical detector arrangements of this type enable a ratio measurement to be achieved, which reduces the contribution of the skull and skin, thus allowing quantification. Cerebral haemoglobin concentration can be converted in CBV, as the haemoglobin concentration in the blood is known.
CBV can be quantified by MRI using an indicator dilution method. The method requires an injection of a paramagnetic contrast agent. The input function can be measured at the throat and thus perfusion images can be quantified.
CBV was measured by NIRS just before the patient entered the magnet and after he had left it. The sensor for the NIRS measurement was applied to the patients front three times for 1 minute to each side, avoiding the sinuses. CBV was determined by contrast enhanced MRI between the NIRS measurements.
The mean CBV (NIRS) was 8.6 (SD 1.3) ml/100g and CBV (MRI) was 7.1 (SD 2.5). The correlation between CBV (NIRS) and CBV (MRI) was Pearson’s correlation coefficient -0.297 (p = 0.204) respectively Spearman’s rho (nonparametric) -0.266 (p = 0.257). The CBV values obtained by NIRS and MRI, even though they are in the same range, do not correlate.
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References
Bland JM and Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 2:307–310.
Bucher HU, Edwards AD, Lipp AE, and Duc G (1993) Comparison between near infrared spectroscopy and 133Xenon clearance for estimation of cerebral blood flow in critically ill preterm infants. Pediatr Res 33:56–60.
Firbank M, Arridge SR, Schweiger M, and Delpy DT (1996) An investigation of light transport through scattering bodies with non-scattering regions. Phys Med Biol 41:767–783.
Okada E, Firbank M, Schweiger M, Arridge SR, Cope M, and Delpy DT (1995) A theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue. SPIE 2626:2–8.
Owen-Reece H, Elwell CE, Harkness W, Goldstone J, Delpy DT, Wyatt JS, and Smith M (1996) Use of near infrared spectroscopy to estimate cerebral blood flow in conscious and anaesthetized adult subjects. Brit J of Anaesthesia 76:43–48.
Rempp KA, Brix G, Wenz F, Becker CR, Gückel F, and Lorenz WJ (1994) Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR Imaging. Radiology 193:637–641.
Skov L, Pryds O, and Greisen G (1991) Estimating cerebral blood flow in newborn infants: comparison of near infrared spectroscopy and 133Xe clearance. Pediatr Res 30:570–573.
Wolf M, Evans P, Bucher HU, Dietz V, Keel M, Strebel R, and von Siebenthal K (1997) The Measurement of Absolute Cerebral Haemoglobin Concentration in Adults and Neonates. Adv Exp Med Biol 428:219–227.
Wyatt JS, Cope M, Delpy DT, Richardson CE, Edwards AD, Wray S, and Reynolds EO (1990) Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy. J Appl Physiol 68:1086–1091.
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© 1999 Springer Science+Business Media New York
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Wolf, M. et al. (1999). Comparison of Cerebral Blood Volume Measured by Near Infrared Spectroscopy and Contrast Enhanced Magnetic Resonance Imaging. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_88
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_88
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