Abstract
The sources of spontaneous mutations and molecular details that underlay the production of spontaneous mutations are still poorly understood. One source is related to DNA metabolism involving DNA replication and repair (1,2). Some of the mutator loci indentified in E. coli are related to structural genes for DNA polymerase, and one of them is related to the polA gene, the gene for DNA polymerase I.
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Savic, D.J., Jankovic, M., Kostic, T., Glickman, B.W. (1991). Molecular Basis of Mutagenesis in Escherichia Coli K12 Deficient for DNA Polymerase I: Special Role of the Gtcg Sequence. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_8
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_8
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